Clotrimazole tablets

This product belongs to the azole antifungal drug, and it can inhibit the process of Candida albicans transforming from spores to invasive hyphae. This product has a broad-spectrum antifungal activity, and has good antibacterial effects on Epidermophyton, Trichophyton, Aspergillus, Chromatid fungi, Cryptococcus and Candida. It also has certain antibacterial activity against Sporothrix schenckii, Blastomyces dermatitidis, Coccidioides and Histoplasma. This product has poor effects on Aspergillus, some dark spores, Mucor and other genus. This product inhibits the biosynthesis of ergosterol, the main steroid of fungal cell membrane, by interfering with the activity of cytochrome P-450, damaging the fungal cell membrane and changing its permeability, resulting in leakage of important intracellular substances. This product can inhibit the biosynthesis of triglycerides and phospholipids of fungi, inhibit the activity of oxidases and peroxidases, and cause the accumulation of hydrogen peroxide in cells, leading to cell submicrostructure degeneration and cell necrosis.

Clotrimazole.

This product is off-white to slightly yellow tablets.

It is used to prevent and treat oral and esophageal Candida infections in immunosuppressed patients. However, due to its poor oral absorption, poor efficacy in treating deep fungal infections, and common adverse reactions, it is now rarely used and is only used topically.

Oral administration: 0.25-1g at a time, 0.75-3g per day. Children: 20-60mg/kg per day, divided into 3 doses.

1. Common gastrointestinal reactions after oral administration, generally after starting to take the drug, there will be anorexia, nausea, vomiting, abdominal pain, diarrhea, etc., and severe cases often need to stop taking the drug. 2. Hepatotoxicity: Since most of this product is metabolized in the liver, liver damage may occur, causing elevated serum bilirubin, alkaline phosphatase and aminotransferase, which can be restored after stopping the drug. 3. Occasionally, temporary neuropsychiatric abnormalities may occur, manifested as depression, hallucinations and disorientation. Once such reactions occur, treatment must be discontinued.

Patients with hepatic insufficiency, granulocytopenia and adrenal cortex insufficiency are contraindicated to use this product or other imidazoles. ... allergic reaction to this product or other imidazoles are contraindicated to use this product.

Precautions for children: This product is contraindicated for patients under 18 years old, or can only be used under the guidance of a physician. There are currently no clinical research reports on this age group. Precautions for pregnancy and lactation: Unless under the supervision of a physician, it is best not to use this product during pregnancy. Precautions for the elderly: Not yet clear.

Drug interactions may occur if used with other drugs. Please consult your doctor or pharmacist for details.

seal.

0.25g

24 months

Zengcheng Guangzhou Ouhua Pharmaceutical Co., Ltd.

• Founded in:

  1993-12-29

• Address:

  Room 1701, Building 3, No. 14, Innovation Avenue, Ningxi Street, Zengcheng District, Guangzhou

• Tax NO.:

  91440183618793970T

• Registered Funds:

  HK$17.5 million

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