Nifedipine Tablets

Nifedipine (NF) inhibits the influx of calcium ions into cells by blocking the membrane transport of calcium ions in myocardial and vascular smooth muscle, causing decreased myocardial contractility and vasodilation. Animal experiments have shown that it reduces myocardial oxygen consumption by reducing myocardial contractility and peripheral vascular resistance; increases oxygen supply to myocardial ischemic sites by dilating coronary vessels and developing collateral circulation; and enhances anti-hypoxia capabilities by inhibiting the consumption of high-energy phosphate compounds.

The main ingredient of this product is nifedipine.

Thin-coated tablets, yellow in color after removing the film coating.

1. Angina pectoris: variant angina pectoris; unstable angina pectoris; chronic stable angina pectoris. 2. Hypertension (alone or in combination with other antihypertensive drugs).

1. The dose of nifedipine should be gradually adjusted depending on the patient's tolerance and control of angina pectoris. Overdose of nifedipine can lead to hypotension. 2. Start with a low dose, generally the starting dose is 10 mg/time, orally 3 times a day; the commonly used maintenance dose is 10-20 mg/time orally 3 times a day. For some patients with obvious coronary artery spasm, it can be used up to 20-30 mg/time, 3-4 times a day. The maximum dose should not exceed 120 mg/day. If the condition is urgent, 10 mg/time can be chewed or taken sublingually, and the decision to re-administer the drug will be based on the patient's response to the drug. 3. It usually takes 7-14 days to adjust the dose. If the patient's symptoms are obvious and the condition is urgent, the dose adjustment period can be shortened

1. Common peripheral edema after taking the drug (peripheral edema is related to the dose, the incidence is 4% when taking 60 mg/day, and 12.5% when taking 120 mg/day); dizziness; headache; nausea; fatigue and facial flushing (10%). Transient hypotension (5%), most of which do not require discontinuation of the drug (transient hypotension is related to the dose, the incidence is 2% when taking 60 mg/day, and the incidence is 5% when taking 120 mg/day). Some patients experience angina pectoris, which may be related to the hypotensive reaction. Palpitations; nasal congestion; chest tightness; shortness of breath; constipation; diarrhea; gastrointestinal cramps; abdominal distension; skeletal muscle inflammation; joint stiffness; muscle spasms; mental tension; tremors; nervousness; sleep disorders; blurred vision; imbalance, etc. (2%) can also be seen. Syncope (0.5%), which will no longer occur if the dose is reduced or used in combination with other anti-anginal drugs. 2. Rare anemia; leukopenia; thrombocytopenia; purpura; allergic hepatitis; gingival hyperplasia; depression; paranoia; instant blindness at peak blood concentration; erythromelalgia; antinuclear antibody positive arthritis, etc. (0.5%). 3. Possible serious adverse reactions: myocardial infarction and congestive heart failure occur in 4% of cases; pulmonary edema occurs in 2% of cases; arrhythmia and conduction block occur in less than 0.5% of cases each. 4. Allergic hepatitis, rash, and even exfoliative dermatitis may occur in patients allergic to this product.

It is contraindicated in patients allergic to nifedipine.

Precautions for children: Not clear yet. Precautions for pregnancy and lactation: 1. No detailed clinical research data. Nifedipine is clinically used for pregnant women with hypertension. 2. Nifedipine can be secreted into breast milk, so lactating women should stop taking the drug or stop breastfeeding. Precautions for the elderly: The half-life of nifedipine is prolonged in the elderly, so pay attention to adjusting the dose when using it.

1. Nitrates. They are well tolerated when used in combination with this product to control angina attacks. 2. Beta-receptor blockers. The vast majority of patients have good tolerance and efficacy when using this product in combination, but some patients may induce and aggravate hypotension, heart failure and angina. 3. Digitalis. This product may increase the blood digoxin concentration, suggesting that the blood concentration of digoxin should be monitored when using it for the first time, adjusting the dose or stopping this product. 4. When drugs with high protein binding rates such as dicoumarins, phenytoin sodium, quinidine, quinine, warfarin, etc. are used with this product, the free concentrations of these drugs often change. 5. When cimetidine is used with this product, the peak plasma concentration of this product increases, so pay attention to adjusting the dose.

Keep in a light-proof and airtight container.

10mg

36 months.

Guangdong Hebo Pharmaceutical Co., Ltd.

• Founded in:

  2013-11-25

• Address:

  Area C, 13th Floor, No. 1, Jiankang Road, Torch Development Zone, Zhongshan City

• Tax NO.:

  91442000084463415N

• Registered Funds:

  61.64153756 million yuan

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