Indomethacin Capsules

This product has anti-inflammatory, antipyretic and analgesic effects. Its mechanism of action is to reduce the synthesis of prostaglandins by inhibiting cyclooxygenase. It stops the formation of pain nerve impulses in inflammatory tissues and inhibits inflammatory reactions, including inhibiting the chemotaxis of leukocytes and the release of lysosomal enzymes. As for the antipyretic effect, it acts on the hypothalamic temperature regulation center, causing peripheral vasodilation and sweating, which increases heat dissipation. This central antipyretic effect may also be related to the inhibition of prostaglandin synthesis in the hypothalamus.

The main ingredients of this product and their chemical names are: The main ingredient of this product is indomethacin, and its chemical name is 2-methyl-1-(4-chlorobenzoyl)-5-methoxy-1H-indole-3-acetic acid.

This product is a capsule containing white powder

Used for: 1 Arthritis, to relieve pain and swelling. 2 Soft tissue injury and inflammation; 3 Antipyretic; 4 Others: used to treat migraine, dysmenorrhea, postoperative pain, post-traumatic pain, etc.

Oral 1 Common adult dose (1) Anti-rheumatic, initial dose 25-50 mg (1-2 tablets) once, 2-3 times a day, the maximum daily dose should not exceed 150 mg (6 tablets). (2) Analgesia, first dose 25-50 mg (1-2 tablets) once, followed by 25 mg (1 tablet) 3 times a day, until the pain is relieved, then the drug can be discontinued; (3) Antipyretic, once 6.25-12.5 mg (1/4-half tablet), no more than 3 times a day. 2 Common pediatric dose: 1.5-2.5 mg/kg per day, divided into 3-4 times. Reduce to the lowest dose after it is effective.

This product has many adverse reactions. 1. Gastrointestinal tract: symptoms such as indigestion, stomach pain, burning sensation in the stomach, nausea and acid reflux, ulcers, gastric bleeding and gastric perforation; 2. Nervous system: headache, dizziness, anxiety and insomnia, and in severe cases, mental and behavioral disorders or convulsions; 3. Kidney: hematuria, edema, renal insufficiency, more common in the elderly; 4. Various types of rashes, the most serious of which is bullous erythema multiforme (Stevens-Johnson syndrome); 5. The hematopoietic system is suppressed, resulting in aplastic anemia, leukopenia or thrombocytopenia, etc.; 6. Allergic reactions

It is contraindicated for patients with active ulcer disease, ulcerative colitis or a history of the disease, epilepsy, Parkinson's disease and mental illness, liver and kidney dysfunction, allergic to this product or to aspirin or other non-steroidal anti-inflammatory drugs, angioedema or bronchial asthma.

Precautions for children: Children under 14 years old are generally not suitable for this drug. If it must be used, it should be closely observed to prevent the occurrence of serious adverse reactions. Precautions for pregnancy and lactation: 1. This product can cause fetal ductus arteriosus occlusion and persistent pulmonary hypertension when used in the last 3 months of pregnancy. It is contraindicated for pregnant women. 2. This product can be excreted from breast milk and can cause toxic and side effects to infants. It is contraindicated for lactating women. Precautions for the elderly: Elderly patients are prone to renal toxicity and should be used with caution.

1 Long-term co-use with acetaminophen can increase renal toxicity, and the incidence of gastrointestinal ulcers increases when used with other non-steroidal anti-inflammatory drugs. 2 When used with aspirin or other salicylates, it does not enhance the therapeutic effect, but the gastrointestinal adverse reactions increase significantly. Due to the enhanced inhibition of platelet aggregation, the bleeding tendency may increase. 3 Drinking alcohol or using it with corticosteroids and adrenocorticotropic hormone may increase the risk of gastrointestinal ulcers or bleeding. 4 When used with digitalis drugs, this product can increase the blood concentration of digitalis (due to inhibiting clearance from the kidneys) and increase toxicity, so the dose of digitalis needs to be adjusted. 5 Use with heparin, oral anticoagulants and

Keep away from light and store in sealed container.

25mg

24 months

Hebei Kangtai Pharmaceutical Co., Ltd.

• Founded in:

  2003-08-11

• Address:

  No. 21, Jiuhe East Road, Cangzhou Economic Development Zone

• Tax NO.:

  91130901109750200T

• Registered Funds:

  12 million yuan

• Website:

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