Succinylcholine Chloride Injection

After binding to nicotinic receptors, this product produces a stable depolarization effect, causing skeletal muscle relaxation. This product can be quickly hydrolyzed by pseudocholinesterase in the blood after entering the body, and its intermediate metabolite succinyl monocholine has a very weak muscle relaxant effect. After intravenous injection, this product first causes a short muscle fasciculation, starting from small muscles such as the brow and upper eyelid, to the scapula and pectoralis major, and to the upper and lower limbs. The muscle relaxant effect takes effect in 60 to 90 seconds and lasts for about ten minutes. Repeated intravenous injection or continuous infusion can prolong the effect. The muscle relaxant effect takes effect in 60 to 90 seconds and lasts for about 10 minutes. Large doses can cause a slow heart rate, and arrhythmias such as rhythmic rhythm and premature contractions may also occur. Histamine release causes bronchospasm or anaphylactic shock. If the dose exceeds 1g, desensitization blockade is likely to occur, delaying the recovery of muscle tension. This product can cause cerebral vasodilation, increased intracranial pressure, orbital smooth muscle contraction, temporary increase in intraocular pressure, postoperative muscle pain, myoglobulinuria, etc.; long-term depolarization can lead to K outflow from muscle cells and increased blood potassium. In addition, this product can induce malignant hyperthermia.

Succinylcholine Chloride

This product is a colorless or almost colorless clear viscous liquid.

Depolarizing skeletal muscle relaxant. It can be used for endotracheal intubation during general anesthesia and to maintain muscle relaxation during surgery.

This product must be used under conditions of assisted or controlled breathing: 1. When intubating, 1-1.5 mg/kg, up to 2 mg/kg; 1-2 mg/kg for children, diluted with 0.9% sodium chloride injection to 10 mg per ml, intravenous or deep intramuscular injection, intramuscular injection should not exceed 150 mg at a time. 2. To maintain muscle relaxation: 150-300 mg at a time dissolved in 500 ml of 5%-10% glucose injection or 1% procaine hydrochloride injection mixed solution and intravenously dripped.

1. Hyperkalemia This product causes muscle fiber depolarization, causing K in the cells to flow rapidly to the extracellular space. Normal human blood potassium rises by 0.2-0.5mmol/L; severe burns, soft tissue injuries, intra-abdominal infections, tetanus, paraplegia and hemiplegia, etc., under the action of this product, cause abnormal large amounts of K outflow leading to hyperkalemia, severe ventricular arrhythmias and even cardiac arrest. 2. Cardiac effects The acetylcholine-mimetic effect of this product can cause bradycardia, nodal arrhythmias and cardiac arrest, especially when repeated large doses are administered. 3. Increased intraocular pressure This product causes spasmodic contraction of the extraocular muscles, resulting in increased intraocular pressure. 4. The increase in intragastric pressure can reach up to 40cmH2O, and can cause reflux and aspiration of gastric contents in patients with a full stomach. 5. Malignant hyperthermia is more common in patients who take this product in combination with halothane.

1. Patients with cerebral hemorrhage, glaucoma, retinal detachment, cataract extraction, low plasma cholinesterase, severe trauma, large-area burns, upper motor neuron damage and hyperkalemia are contraindicated. 2. Patients using anticholinesterase drugs should use with caution.

Precautions for children: This experiment has not been conducted and there is no reliable reference. Precautions for pregnancy and lactation: Pregnant women should use with caution. Precautions for the elderly: This experiment has not been conducted and there is no reliable reference.

1 This product decomposes in alkaline solution, so it should not be mixed with sodium thiopental for injection. 2 The following drugs can reduce the activity of pseudocholinesterase and enhance the effect of this product. ① Anticholinesterase drugs. ② Anti-tumor drugs such as cyclophosphamide, nitrogen mustard, and thiotepa. ③ Local anesthetics such as procaine. ④ Monoamine oxidase inhibitors, estrogen, etc. 3 It should also be used with caution with the following drugs, such as: phenothiazines, procainamide, quinidine, kanamycin, polymyxin B, neomycin, etc. have depolarizing muscle relaxant effects and can enhance the effect of this product.

Sealed storage

2 ml: 0.1 g

36 months

Shanghai Xudong Haipu Pharmaceutical Co., Ltd.

• Founded in:

  1993-01-06

• Address:

  No. 879, Jinhu Road, China (Shanghai) Pilot Free Trade Zone

• Tax NO.:

  91310115607203592Y

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  $9,478,623

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