Erythromycin Granules

Erythromycin granules belong to the macrolide antibiotics, which are the dodecyl sulfate of erythromycin propionate. They have antibacterial activity against Staphylococcus, various groups of streptococci and Gram-positive bacilli. Neisseria, Haemophilus influenzae, Bordetella pertussis, etc. may also be sensitive to erythromycin granules. Erythromycin granules also have antibacterial activity against various anaerobic bacteria except Bacteroides fragilis and Fusobacterium; they also have inhibitory effects on Legionella, Campylobacter fetus, some spirochetes, Mycoplasma pneumoniae, Rickettsia and Chlamydia. Erythromycin granules are antibacterial agents, but they also have bactericidal effects on some bacteria at high concentrations. Erythromycin granules can penetrate the bacterial cell membrane and reversibly bind to the 50S subunit of the bacterial ribosome near the donor site (P site), blocking the transfer RNA (t-RNA) binding to the P site, and also blocking the displacement of the polypeptide chain from the acceptor site (A site) to the P site, thereby inhibiting bacterial protein synthesis. Erythromycin granules are only effective against bacteria that are actively dividing.

Main ingredients: Erythromycin.

Erythromycin granules are granules with added flavoring agents; they have a fragrant aroma and a sweet taste.

1. Erythromycin granules are used as an alternative medicine for the treatment of the following infections in patients allergic to penicillin: acute tonsillitis, acute pharyngitis, sinusitis caused by hemolytic streptococci, pneumococci, etc.; scarlet fever and cellulitis caused by hemolytic streptococci; diphtheria and diphtheria carriers; gas gangrene, anthrax, tetanus; actinomycosis; syphilis; listeriosis, etc. 2. Legionnaires' disease. 3. Mycoplasma pneumoniae pneumonia. 4. Chlamydia pneumoniae pneumonia. 5. Urinary and reproductive system infections caused by other Chlamydia and Mycoplasma species. 6. Chlamydia trachomatis conjunctivitis. 7. Oral infections caused by anaerobic bacteria. 8. Campylobacter jejuni enteritis. 9. Whooping cough. 10. Recurrent rheumatic fever, infective endocarditis (after rheumatic heart disease, congenital heart disease, heart valve replacement), oral and upper respiratory tract medical procedures (alternative to penicillin).

Oral administration: 1-2g per day for adults, divided into 3-4 times; 20-30mg/kg per day for children, divided into 3-4 times. For the treatment of Legionnaires' disease, 0.5-1.0g per time, 4 times a day for adults. When used as a preventive medication for recurrent rheumatic fever, 0.25g per time, 2 times a day. When used as a preventive medication for infective endocarditis, 1g is taken orally 1 hour before surgery, and 0.5g is taken 6 hours after surgery.

1. Patients who take erythromycin granules are more likely to experience hepatotoxic reactions than those who take other erythromycin preparations. After taking the medicine for several days or 1 to 2 weeks, patients may experience fatigue, nausea, vomiting, abdominal pain, rash, fever, etc. Jaundice may sometimes occur, and liver function tests show cholestasis, which can often be recovered after stopping the drug. 2. Gastrointestinal reactions include diarrhea, nausea, vomiting, upper abdominal pain, pain in the mouth and tongue, and decreased appetite, and their incidence is related to the size of the dose. 3. When used in large doses (ge; 4g/day), especially in patients with liver and kidney diseases or elderly patients, hearing loss may occur, which is mainly related to the high blood drug concentration (12mg/L), and most of them can be recovered after stopping the drug. 4. Allergic reactions are manifested as drug fever, rash, eosinophilia, etc., with an incidence of about 0.5% to 1%. 5. Others: Occasionally there are arrhythmias and oral or vaginal candidal infections.

It is contraindicated for those who are allergic to erythromycin drugs. [Precautions for use by pregnant and lactating women] 1. Erythromycin granules can pass through the placenta and enter the fetal circulation, and pregnant women are more likely to experience hepatotoxic reactions after taking erythromycin granules, so pregnant women should not use it. 2. A considerable amount of erythromycin enters breast milk, so lactating women should stop breastfeeding when using it.

Precautions for children: Not yet clear. Precautions for pregnancy and lactation: [Precautions for pregnant and lactating women] Erythromycin granules can pass through the placenta and enter the fetal circulation, and pregnant women are more likely to experience hepatotoxic reactions after taking erythromycin granules, so pregnant women should not use it. A considerable amount of erythromycin enters breast milk, so lactating women should stop breastfeeding when using it. Precautions for the elderly: Not yet clear.

1. Erythromycin granules can inhibit the metabolism of antiepileptic drugs such as carbamazepine and valproic acid, resulting in increased blood concentrations of the latter and toxic reactions. Erythromycin granules combined with alfentanil can inhibit the metabolism of the latter and prolong its duration of action. Erythromycin granules combined with antihistamines such as astemizole or terfenadine can increase cardiac toxicity, and combined with cyclosporine can increase the latter's blood concentration and produce nephrotoxicity. 2. It has an antagonistic effect with chloramphenicol and lincosamides, and is not recommended for combined use. 3. Erythromycin granules are antibacterial agents that can interfere with the bactericidal efficacy of penicillin. Therefore, when rapid bactericidal effects are required, such as the treatment of meningitis, the two should not be used together. 4. Patients who have been taking warfarin for a long time may have a prolonged prothrombin time when using erythromycin, thereby increasing the risk of bleeding. Elderly patients should pay special attention. When the two must be used together, the dose of warfarin should be appropriately adjusted and the prothrombin time should be closely observed. 5. In addition to dihydroxypropylphylline, the combination of erythromycin granules and xanthines can reduce the hepatic clearance of aminophylline, leading to increased serum aminophylline concentrations and (or) increased toxic reactions. This phenomenon is more likely to occur after 6 days of combined use, and the reduction in aminophylline clearance is proportional to the serum peak of erythromycin granules. Therefore, the dose of xanthines should be adjusted during and after the combined treatment of the two. 6. Combination with other hepatotoxic drugs may enhance hepatotoxicity. 7. The combination of high-dose erythromycin granules with ototoxic drugs, especially in patients with renal impairment, may increase ototoxicity. 8. When used in combination with lovastatin, its metabolism can be inhibited and blood concentrations can be increased, which may cause rhabdomyolysis. When used in combination with midazolam or triazolam, the clearance of both can be reduced and their effects can be enhanced.

Keep away from light and sealed.

75 mg (75,000 units) of erythromycin

24 months

Yabao PHARMA Sichuan Pharmaceutical Co., Ltd.

• Founded in:

  2003-01-17

• Address:

  No. 368, Baijiang North Road, Pengzhou Industrial Development Zone, Sichuan Province

• Tax NO.:

  9151018274640006XE

• Registered Funds:

  28 million yuan

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