Pharmaceutical Grade 99% Purity Tacrolimus Powder CAS 104987-11-3
GMP ISO 2 Inquiries
104987-11-3
Pharmaceutical Grade
0%
Foil Bag, Box, Drum
2022-12-31
Minoxidil,Paracetamol,Diclofenac sodium,fenbendazole,Ivermectin
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Product Description
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Seller Information
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Inquiry History
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Description
Tacrolimus CAS: 104987-11-3
Tacrolimus MF: C44H69NO12
Tacrolimus MW: 804.02
Tacrolimus Product Categories:Pharmaceuticals;Chiral Reagents;Fujimycin, Prograf;antibiotic
Tacrolimus Chemical Properties: White Crystalline Solid
Tacrolimus Assay:99%
Tacrolimus Usage: An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.
Packing:2g/foil bag
"Tacrolimus" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
Tacrolimus (also FK-506 or Fujimycin) is an immunosuppressive drug whose main use is after organ transplant to reduce the activity of the patient's immune system and so the risk of organ rejection. It is also used in a topical preparation in the treatment of severe atopic dermatitis, severe refractory uveitis after bone marrow transplants, and the skin condition vitiligo.
Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription.
Tacrolimus COA:Tests Specifications Results Description A white or off-white crystalline powder Conform Identification 1. IR (USP <197K>) Conform 2. HPLC retention times Conform Water
(USP <921> Method I)1.6 ~ 3.0% 2.1% Residue on ignition
(USP <281>)£ 0.2% 0.08% Heavy metals
(USP <231> II)£ 20 ppm < 20 ppm Related substances (In-house HPLC method) Ascomycin £ 0.8% 0.064% Residual solvents
(In-house method)Ace £ 2000 ppm Not detected Assay (on anhydrous basis) 98.0% ~ 102.0% 100.0% Conclusion: Complied with In-House standard
Tacrolimus is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). This medicine may be used with steroids, azathioprine, basiliximab, or mycophenolate mofetil. Tacrolimus belongs to a group of medicines known as immunosuppressive agents.
Tacrolimus is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body's ability to fight infections. You and your doctor should talk about the benefits of this medicine as well as the risks of using it.
Tacroz Forte Ointment (Tacrolimus) is used to treat atopic dermatitis (more commonly known as eczema). It is a topical medication which is normally prescribed for patients who have not responded successfully to other eczema medication.
The ointment is a type of topical calcineurin inhibitor (TCIs) that works by weakening the patient`s immune system, which as a consequence directly reduces the severity of eczema and its symptoms. It should not be used by patients who have any kind of weak immune system.
CertificatesBasic Info-
Product Name:
Tacrolimus
Other Name:15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,[3S-[3R*[E(1S*,3S*,4S*)],4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26aR*]]-;15,19-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone,5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-;(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-Hexadecahydro-5,19-dihydroxy-3-[(1E)-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propen-1-yl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone;FR 900506;FK 506;Tsukubaenolide;L 679934;Fujimycin;(-)-FK 506;Tacrolimus;Prograf;Protopic;Advagraf;TacroBell;FK506;Prograph;Envarsus XR;Astagraf XL;Hecoria;Tacropic;Protopy;Modigraf;Envarsus
CAS No.:104987-11-3
Molecular Formula:C44H69NO12
InChIKeys:InChIKey=QJJXYPPXXYFBGM-LFZNUXCKSA-N
Molecular Weight:804.02
Exact Mass:804.02
EC Number:1308068-626-2
DSSTox ID:DTXSID5046354
Categories:
Characteristics-
PSA:
178 Ų
XLogP3:3.3
Appearance:white solid
Density:1.2±0.1 g/cm3
Melting Point:113-115°C
Flash Point:2℃
Refractive Index:1.549
Water Solubility:Freely soluble in DMSO or ethanol. Poorly soluble in water.soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.DMSO: >3 mg/mL
Storage Conditions:−20°C
Vapor Pressure:8.37X10-32 mm Hg at 25 °C (est)
Henrys Law Constant:Henry's Law constant = 4.74X10-24 atm-cum/mol at 25 °C (est)
Dissociation Constants:pKa1 = 2.94; pKa2 = 9.95; pKa3 = 14.07 (est)
Experimental Properties:Hydroxyl radical reaction rate constant = 3.81X10-10 cu cm/molec-sec at 25 °C (est)|Ozone radical reaction rate constant = 8.719X10-16 cu cm/molec-sec at 25 °C (est)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
Reproductive toxicity, Category 2
Specific target organ toxicity â repeated exposure, Category 1
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
H361 Suspected of damaging fertility or the unborn child
H372 Causes damage to organs through prolonged or repeated exposure
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
P319 Get medical help if you feel unwell.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Minoxidil,Paracetamol,Diclofenac sodium,fenbendazole,Ivermectin
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Location:
I-City unit 3, South of Tangyan Road, Hi-Tech Industrial Zone, Xi'an City, Shaanxi Province, China
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Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
7
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Total Annual Revenue:
$1 million-$2.5 million
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Total Employees:
51-100
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Year of Establishment:
2015
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Certifications:
HACCP,Halal,GMP,ISO
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Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Uzbekistan
China GMP Factory Direct Supply 99% Purity Tacrolimus FK-506 powder CAS 104987-11-3 Sinoway
1 KG Oct 12, 2023 
Saudi Arabia
Tacrolimus
10 G Sep 14, 2024 Post an enquiry for this product
