Carmustin
2 Inquiries
154-93-8
99%
Bottle,barrel,cargo,container,etc.
2026-10-05
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
-
Product Description
-
Seller Information
-
Inquiry History
-
DescriptionKeywords
Carmustin
154-93-8
Quick DetailsProName:Carmustin
CasNo:154-93-8
Appearance:powder, or liquid
Application:Pharmaceuticals, intermediates, APIs, custom synthesis, chemicals
DeliveryTime:5-7 Days
PackAge:Bottle, barrel, cargo, container, etc.
Port:Shanghai
Purity:99
Storage:Stored in room temperature, ventilated place
Transportation:By air, ship, express, etc.
LimitNum:0
Grade:Industrial Grade
SuperiorityBest Seller, High Quality, Competitive Price, Fast Delivery, Quick Response
DetailsLEAPChem supplies high quality Pharmaceuticals, intermediates, APIs, custom synthesis, fine chemicals and other industrial chemicalsECHEMI Editorial ReferenceCarmustine is an antitumor chemotherapeutic agent, which works by akylating DNA and RNA.
1,3-bis(2-chloroethyl)-1-nitrosourea is an orange-yellow solid. (NTP, 1992)|Solid
1,3-bis(2-chloroethyl)-1-nitrosourea is an orange-yellow solid. (NTP, 1992)|Carmustine is a member of the class of N-nitrosoureas that is 1,3-bis(2-chloroethyl)urea in which one of the nitrogens is substituted by a nitroso group. It has a role as an alkylating agent and an antineoplastic agent. It is a member of N-nitrosoureas and an organochlorine compound.|A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed)|Carmustine is an Alkylating Drug. The mechanism of action of carmustine is as an Alkylating Activity.|Carmustine (BCNU) is a parenterally administered alkylating agent used alone and in combination with other antineoplastic agents in the treatment of several forms of cancer including leukemias, lymphomas, and breast, testicular, ovarian, gastric and pancreatic cancer. Carmustine therapy is associated with minor transient serum enzyme elevations and has been linked to cases of acute liver injury including cholestatic hepatitis and acute veno-occlusive disease.|Carmustine is an antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)Basic Info-
Product Name:
Carmustine
Other Name:Urea,N,N′-bis(2-chloroethyl)-N-nitroso-;Urea,1,3-bis(2-chloroethyl)-1-nitroso-;N,N′-Bis(2-chloroethyl)-N-nitrosourea;BCNU;1,3-Bis(2-chlorethyl)-1-nitrosourea;Carmustine;1,3-Bis(β-chloroethyl)-1-nitrosourea;NSC 409962;Carmustin;1,3-Bis(2-chloroethyl)-1-nitrosourea;BiCNU;Gliadel;Becenun;SK 27702;SRI 1720;Nitrumon;FDA 0345;Carmubris;DTI 015;Gliadel Wafer;1,3-Bis(2-chloroethyl)nitrosourea;Becenum;1159711-15-5;1191292-23-5
CAS No.:154-93-8
Molecular Formula:C5H9Cl2N3O2
InChIKeys:InChIKey=DLGOEMSEDOSKAD-UHFFFAOYSA-N
Molecular Weight:214.05
Exact Mass:214.05
EC Number:205-838-2
UNII:U68WG3173Y
NSC Number:758392|409962
UN Number:2811
DSSTox ID:DTXSID8022743
NCI Thesaurus Code:C349
Color/Form:Light yellow powder|Light yellow powder that melts to an oily liquid
ATC Code:L01AD01|L - Antineoplastic and immunomodulating agents
HScode:2924199090
Categories:
Characteristics-
PSA:
61.8
XLogP3:1.5
Appearance:Oily liquid to amorphous solid
Density:1.5±0.1 g/cm3
Melting Point:31 °C
Boiling Point:404ºC
Refractive Index:1.549
Water Solubility:H2O: <0.1 g/100 mL at 18 ºC
Storage Conditions:−20°C
Vapor Pressure:2.9X10-4 mm Hg at 25 deg C (est)
Toxicity:Oral-rat LD50: 20 mg/kg; Oral-Mouse LD50: 19 mg/kg
Flammability characteristics:Combustion produces toxic nitrogen oxides, chloride fumes; poisoning: nausea, vomiting, decreased white blood cells and platelets, bone marrow damage
Henrys Law Constant:Henry's Law constant = 4.8X10-11 atm-cu m/mol at 25 °C (est)
Experimental Properties:Polifeprosan 20 with carmustine implant ... off-white to pale yellow wafer /Gliadel wafer/|Hydroxyl radical reaction rate constant = 3.6X10-12 cu cm/molecule-sec at 25 °C (est)
Air and Water Reactions:Insoluble in water.
Reactive Group:Amides and Imides
Reactivity Profile:1,3-BIS(2-CHLOROETHYL)-1-NITROSOUREA decomposes rapidly in acid and in solutions above pH 7; most stable in petroleum ether or aqueous solution at pH 4. (NTP, 1992)
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 2, Oral
Carcinogenicity, Category 1B
Reproductive toxicity, Category 1B
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H300 Fatal if swallowed
H350 May cause cancer
H360 May damage fertility or the unborn child
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P203 Obtain, read and follow all safety instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
P318 IF exposed or concerned, get medical advice.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Carmustine powder must be refrigerated at 2 - 8 deg C. Both the powder and its solutions must be protected from light.
-
-
Seller Information
-
Business Type:
Trader
-
Main Products:
Intermediates,Building blocks,API,Silicones,Peptides,Lab chemicals
-
Location:
Room A, 23rd Floor, No. 609 Yan'an Road, Gongshu District, Hangzhou, Zhejiang
-
Payment Terms:
TT against copy of documents,D/P,L/C
-
Average lead Time:
5
-
Total Annual Revenue:
Above $100 million
-
Year of Establishment:
2020
-
Certifications:
ISO
">Company ProfileLEAPChem is a specialized fine chemical supplier for research, development and production.
LEAPChem provides nearly 200,000 rare and innovative chemical products to support the evolving needs of our customers in research & bulk manufacturing activities.
As a highly customer-oriented enterprise, we are committed to providing high-quality customer services and products to our global customers in a cost-effective and efficient manner.
Our client list includes many major pharmaceutical and science companies, universities, research institutions and chemical catalogue companies.
Methodology: Sound & Stable; Active & Innovative.
Attitude: Conscientious; Ingenious.
Goals: Customer's Satisfaction
We regard client's success as our success.
At LEAPChem, we strive to be the preferred supplier for efficiency increasing and cost lowering in your Research & Production.
To achieve this strategic vision, we always push ourselves to exceed our customer's requirement. By focusing on the aim of 'Beyond Your Expectation', we continually expand our product lines, and enhance our systematic management and human resources.
Welcome to contact us and we look forward to becoming your reliable and preferred partner.
-
-
Inquiry History2 Inquiries
Country Product Purchase Quantity Date Posted 
Taiwan, China
Carmustine
100 MG Nov 5, 2024 
India
Carmustine
5 G Jun 23, 2025 Post an enquiry for this product
