KU-0063794
938440-64-3
99%
2026-08-10
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName KU-0063794 Cat No CEI-0142 Description Ku-0063794 can inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM. CAS No 938440-64-3 Molecular Weight 465.54 Purity >99% Storage 2 years at -20centigrade Powder Targets mTORC1, mTORC2 Molecular Formula C25H31N5O4 Chemical Name (5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholinopyrido[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol Solubility DMSO 16 mg/mL Water In vitro Ku-0063794 can inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM without inhibiting the activity of 76 other protein kinases or seven lipid kinases. Ku-0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC kinase not regulated by mTOR. Ku-0063794 also inhibited phosphorylation of the T-loop Thr308 residue of Akt phosphorylated by PDK1 (3-phosphoinositide-dependent protein kinase-1). Ku-0063794 can induce a much greater dephosphorylation of the mTORC1 substrate 4E-BP1 (eukaryotic initiation factor 4E-binding protein 1) than rapamycin, even in mTORC2-deficient cells, suggesting a form of mTOR distinct from mTORC1, or mTORC2 phosphorylates 4E-BP1. Ku-0063794 also suppressed cell growth and induced a G1-cell-cycle arrest. category Inhibitors(c1514) cas_num 938440-64-3 Basic Info-
Product Name:
rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol
Other Name:Benzenemethanol,5-[2-[(2R,6S)-2,6-dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-,rel-;rel-5-[2-[(2R,6S)-2,6-Dimethyl-4-morpholinyl]-4-(4-morpholinyl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxybenzenemethanol;Ku 0063794;1427523-77-0
CAS No.:938440-64-3
Molecular Formula:C25H31N5O4
InChIKeys:InChIKey=RFSMUFRPPYDYRD-CALCHBBNNA-N
Molecular Weight:465.551
Exact Mass:465.54
UNII:81HJG228AB
DSSTox ID:DTXSID50239782
Categories:
Characteristics-
PSA:
93.1
XLogP3:2.6
Appearance:white to beige
Density:1.2±0.1 g/cm3
Boiling Point:694.3°C at 760 mmHg
Flash Point:373.7±34.3 °C
Refractive Index:1.609
Water Solubility:DMSO: >2mg/mL (warmed)
Storage Conditions:Store at RT
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product