MK-0752
471905-41-6
99%
Yes
2026-11-27
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Details
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Seller Information
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Description
ProductName MK-0752 Cat No CEI-0207 Description MK-0752 can inhibit gamma secretase with IC50 of 50 nM. CAS No 471905-41-6 Molecular Weight 442.9 Purity >99% Storage 2 years at -20centigrade Powder Targets gamma secretase Molecular Formula C21H21ClF2O4S Chemical Name 3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid Solubility DMSO 89 mg/mL Water In vitro As a inhibitor of gamma secretase, MK-0752 can inhibit the cleavage of gamma secretase substrates such as amyloid precursor protein and Notch with a concentration that inhibits IC50 of 50 nM. And MK-0752 is developed as a treatment Alzheimers disease. MK-0752 leads to G0-G1 arrest in gamma secretase in T-cell acute lymphatic leukemia cell lines carrying notch-activating mutations with IC 50 of 6.2 nM and has demonstrated activity in neuTtransgenic mouse models of mammary tumors. In vivo In animal models of cerebral amyloid formation and deposition, MK-0752 penetrated the brain parenchyma reducing plasmatic amyloid peptide levels by 50% at brain and plasma concentrations of 154 nM and 594 nM. In adults with recurrent solid tumor, the maximum-tolerated dose (MTD) of MK-0752 using the 3-days-on/4-days-off schedule was 450 mg/d with are commended dose of 350mg/d because of fatigue during extended administration. category Inhibitors(c1514) cas_num 471905-41-6 ECHEMI Editorial ReferenceMK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM.IC50 value: 5 nM (reduces Aβ40 production) [1]Target: γ-secretasein vitro: MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells [1]. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation [2]. in vivo: MK-0752 (240 mg/kg) reduces th
Mk 0752 is under investigation in clinical trial NCT00572182 (MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer).|Notch Signaling Pathway Inhibitor MK0752 is a synthetic small molecule with potential antineoplastic activity. MK0752 inhibits the Notch signaling pathway, which may result in induction of growth arrest and apoptosis in tumor cells in which the Notch signaling pathway is overactivated. The Notch signaling pathway plays an important role in cell-fate determination, cell survival, and cell proliferation.Basic Info-
Product Name:
cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid
Other Name:cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;MK-0752/MK0752;3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acidMK-0752;MK-0752, >=98%
CAS No.:471905-41-6
Molecular Formula:C21H21ClF2O4S
InChIKeys:XCGJIFAKUZNNOR-UHFFFAOYSA-N
Molecular Weight:443
Exact Mass:442.081726
UNII:9JD9B4S53T
NCI Thesaurus Code:C49175
HScode:29163990
Categories:
Characteristics-
PSA:
79.8
XLogP3:4.7
Density:1.4±0.1 g/cm3
Flash Point:326.9±31.5 °C
Refractive Index:1.569
Hazard IdentificationClassification of the substance or mixture
no data available
GHS label elements, including precautionary statements
Pictogram(s) no data available Signal word no data available
Hazard statement(s) no data available
Precautionary statement(s) Prevention no data available
Response no data available
Storage no data available
Disposal no data available
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15 days
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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