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PCI-24781

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CAS No.:

783355-60-2

Content:

99%

Price valid (until):

2026-08-19

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Creative Enzymes

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Manufactory

Location:

United States

Qualification:

Main Products:

Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

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Product Description
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Description

ProductName	PCI-24781
Cat No	CEI-0340
Description	PCI-24781
Alias	CRA-02478
CAS No	783355-60-2
Molecular Weight	397.42
Purity	>99%
Storage	2 years at -20 centigrade
Synonyms	CRA-02478
Targets	HDAC1, HDAC2, HDAC3, HDAC6, HDAC8
Molecular Formula	C21H23N3O5
Solubility	No
In vitro	PCI-24781 (CRA-024781) can inhibit HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC10 with Ki of 7 nM, 19 nM, 8.2 nM, 17 nM, 280 nM, 24 nM. PCI-24781 can inhibit multidrug-resistant sarcoma cell lines in dose-dependent accumulation of acetylated histone, p21 and poly(ADP-ribose)polymerase (PARP) cleavage products. PCI-24781 can inhibit sarcoma cell lines with IC50 of 0.43 to 2.7 nM. PCI-24781 reverses drug resistance in all four multidrug-resistant sarcoma cell lines.
In vivo	PCI-24781 [50 mg/kg/day] and control solutions were administered to BK5.erbB2 mice for 4 weeks. Treatment of BK5.erbB2 mice with PCI-24781 for 1 month prevented 79% of GBCa cases from progression and showed a clinical effect in 47% of cases. Treatment with PCI-24781 resulted in decreased expression of Muc4, an intramembrane ligand for ErbB2, in BTC cells. PCI-24781 had more effects on growth inhibition of BTC cells than SAHA. PCI-24781 effectively inhibited the growth of gemcitabine-resistant cells.
category	Inhibitors(c1514)
cas_num	783355-60-2

Basic Info

Product Name:

Abexinostat

Other Name:

2-Benzofurancarboxamide,3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-;3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide;CRA 024781;PCI 24781;CRA 24781;Abexinostat;3-[(Dimethylamino)methyl]-N-[2-[4-(hydroxycarbamoyl)phenoxy]ethyl]-1-benzofuran-2-carboxamide;THM-I 94;BRD K12867552;942630-54-8;883970-69-2

CAS No.:

783355-60-2

Molecular Formula:

C21H23N3O5

InChIKeys:

InChIKey=MAUCONCHVWBMHK-UHFFFAOYSA-N

Molecular Weight:

397.42442

Exact Mass:

397.42

EC Number:

-0

UNII:

IYO470654U

DSSTox ID:

DTXSID30229005

NCI Thesaurus Code:

C68920

Categories:

Inhibitors

Characteristics

PSA:

104

XLogP3:

2.2

Density:

1.3±0.1 g/cm3

Refractive Index:

1.624

See More Abexinostat Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Reproductive toxicity, Category 2

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H361 Suspected of damaging fertility or the unborn child H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Abexinostat Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase

Location:
Shirley, New York 11967, USA

Payment Terms:
TT against copy of documents,D/P

Average lead Time:
15

Total Annual Revenue:
$1 million-$2.5 million

Year of Establishment:
2004

Creative Enzymes is a leading Manufactory supplier of Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl- based in America. With a commitment to quality and customer satisfaction, Creative Enzymes has become a trusted name in the industry. Our product line includes a range of high-quality Proline dipeptidase, Glucoamylase, BenzaMide, N-1H-pyrrolo[2,3-c]pyridin-5-yl-, which are available at competitive prices. Creative Enzymes has established itself as a reliable supplier of chemical products on the echemi.com.
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PCI-24781

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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