SC-514
354812-17-2
0.98%
2026-07-14
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Product Description
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Seller Information
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Description
ProductName SC-514 Cat No CEI-1522 Description SC-514 is an orally active, ATP-competitive inhibitor of IKK-2 with an IC50 value of 3-12 μM. Product Overview SC-514 is a cell-permeable and selective inhibitor of IKK-2 with IC50 value of 3-12μM. SC-514 inhibits all forms of recombinant human IKK-2 with IC50 values in the 3-12μM range. It also inhibits the native IKK complex. SC-514 specifically binds at the ATP-binding site of IKK-2 and exerts a reversible and competitive inhibition with ATP. However, SC-514 shows non-competitive inhibition with the IκB site. As an inhibitor of IKK-2, SC-514 is found to block the phosphorylation and degradation of IκBα and reduce the translocation level of p65 into the nucleus in IL-1β-treated RASFs. Additionally, SC-514 shows dose-dependent inhibition in the transcription of NF-κB-induced genes, including IL-6, IL-8, and COX-2.Moreover, SC-514 shows efficacious in reduction of LPS-induced TNFα production in the acute model of inflammation. SC-514 is also reported to inhibit the osteoclastogenesis in BMM cells through attenuating RANKL-induced activation of NF-κB. CAS No 354812-17-2 Molecular Weight 224.3 Purity 0.98 Storage Store at-20° C Targets IKK-2; CDK2/CyclinA; AUR2; PRAK; p38α IC50 3-12 μM; 61 μM; 71 μM; 75 μM; >100 μM Molecular Formula C9H8N2OS2 Chemical Name 3-amino-5-thiophen-3-ylthiophene-2-carboxamide Solubility Soluble in DMSO > 10 mM Shipping Conditions Evaluation sample solution: ship with blue ice. All other available size: ship with RT, or blue ice upon request category Inhibitors(c1514) cas_num 354812-17-2 Basic Info-
Product Name:
3-Amino-5-(3-thienyl)thiophene-2-carboxamide
Other Name:[2,3′-Bithiophene]-5-carboxamide,4-amino-;4-Amino[2,3′-bithiophene]-5-carboxamide;4-Amino-[2,3′]bithiophenyl-5-carboxamide;3-Amino-5-(3-thienyl)thiophene-2-carboxamide;SC 514;GK 01140;3-Amino-5-thiophen-3-ylthiophene-2-carboxamide;3-Amino-5-(thiophen-3-yl)thiophene-2-carboxamide
CAS No.:354812-17-2
Molecular Formula:C9H8N2OS2
InChIKeys:InChIKey=BMUACLADCKCNKZ-UHFFFAOYSA-N
Molecular Weight:224.30262
Exact Mass:224.30
Categories:
Characteristics-
PSA:
126
XLogP3:2
Appearance:white to light brown
Melting Point:209-211°C
Boiling Point:399.2°C at 760 mmHg
Water Solubility:DMSO: soluble 10mg/mL, clear
Storage Conditions:Store at +4°C
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 3, Oral
GHS label elements, including precautionary statements
Pictogram(s) 
Signal word Danger
Hazard statement(s) H301 Toxic if swallowed
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
Response P301+P316 IF SWALLOWED: Get emergency medical help immediately.
P321 Specific treatment (see ... on this label).
P330 Rinse mouth.
Storage P405 Store locked up.
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.
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Seller Information
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Business Type:
Manufactory
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Main Products:
Coenzymes,Inhibito,Enzymes,Zymogens,Substrates,Native Microorganism Creatine Amidinohydrolase
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Location:
Shirley, New York 11967, USA
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Payment Terms:
TT against copy of documents,D/P
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Average lead Time:
15
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Total Annual Revenue:
$1 million-$2.5 million
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Year of Establishment:
2004
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Country Product Purchase Quantity Date Posted Post an enquiry for this product