Kindchem key chemicals Tegoprazan

Other Name:

RQ-4
CJ 12420
Tegoprazan
RQ-00000004
Tegoprazan Emixustat HCL Hydrochloride
7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-chromen-4-yl]oxy]-N,N,2-trimethyl-3H-benzimidazole-5-carboxamide
7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-1H-benzimidazole-5-carboxamide
1H-Benzimidazole-5-carboxamide, 7-[[(4S)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-yl]oxy]-N,N,2-trimethyl-

Applications:
It is used in the treatment of gastroesophageal reflux disease and erosive esophagitis. Mechanism of action Tegorazan is a Potassium CompetitiveAcidBlockers (P-CAB). As a new type of Chemicalbook acid-inhibiting drug, Tegorazan has a novel acid-inhibiting mechanism, as shown in the following figure. Tigorazan acts on resting or activated H+/K+ -ATPase through hydrogen and ionic bonds, thereby inhibiting the conformational change of the enzyme, making it unable to complete the exchange of hydrogen and potassium, and acting as an acid inhibitor.

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Dry. Well closed. Separated from food and feedstuffs and strong oxidants. Store in an area without drain or sewer access.

Inhalation: Remove victim to fresh air and keep at rest in a position comfortable for breathing. Get medical advice/attention if you feel unwell

Skin contact: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. If skin irritation or rash occurs: Get medical advice/attention.

Eye contact :Rinse cautiously with water for several minutes. Remove contact lenses, if present

Ingestion ： Get medical advice/attention if you feel unwell. Rinse mouth. Protection of first-aiders: A rescuer should wear personal protective equipment, such as rubber gloves and air tight goggles

DISPOSAL CONSIDERATIONS

Recycle to process, if possible. Consult your local regional authorities. You may be able to dissolve or mix material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber system. Observe all federal, state and local regulations when disposing of the substance.

REGULATORY INFORMATION

Safe management ordinance of dangerous chemical product (State Council announces on 27/07/2022):

Safe use and production, the storage of a dangerous chemical, transport, loading and unloading were prescribed.

Consignor: Kindchem(Nanjing)Co.,Ltd

Add:No.8-4,HongGuang Road Qinhuai District,Nanjing City,China,210006

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