High Quality 99% Perphenazine CAS 58-39-9 Powder Fast Shipping Best Price
TDS 3 Inquiries
58-39-9
Pharmaceutical Grade
99.5%
Hangzhou
HyperChem
1kg/Bag
2024-12-14
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements
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Product Description
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Seller Information
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Inquiry History
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DescriptionECHEMI Editorial ReferencePerphenazine is a typical antipsychotic drug, inhibits 5-HT2Areceptor, Alpha-1A adrenergic receptor, Dopamine receptor D2/D3, D2L receptor, and Histamine H1 receptor, with Ki values of 5.6, 10, 0.765/0.13, 3.4, and 8 nM, respectively.
Solid
Perphenazine is a phenothiazine derivative in which the phenothiazine tricycle carries a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at N-10. It has a role as a phenothiazine antipsychotic drug, a dopaminergic antagonist and an antiemetic. It is a member of phenothiazines, a N-alkylpiperazine, a N-(2-hydroxyethyl)piperazine and an organochlorine compound. It derives from a hydride of a 10H-phenothiazine.|An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine.|Perphenazine is a Phenothiazine.|Perphenazine is a phenothiazine and antipsychotic agent, now rarely used in clinical practice. Perphenazine can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury.|Perphenazine is a phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors.|An antipsychotic phenothiazine derivative with actions and uses similar to those of CHLORPROMAZINE.CertificatesBasic Info-
Product Name:
Perphenazine
Other Name:1-Piperazineethanol,4-[3-(2-chloro-10H-phenothiazin-10-yl)propyl]-;1-Piperazineethanol,4-[3-(2-chlorophenothiazin-10-yl)propyl]-;4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol;2-Chloro-10-3-[1-(2-hydroxyethyl)-4-piperazinyl] propyl phenothiazine;2-Chloro-10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]phenothiazine;Decentan;Etaperazin;Etaperazine;Ethaperazine;Fentazin;1-(2-Hydroxyethyl)-4-[3-(2-chloro-10-phenothiazinyl)propyl]piperazine;γ-[4-(β-Hydroxyethyl)piperazin-1-yl]propyl-2-chlorophenothiazine;Perphenazin;Perphenazine;Trifaron;Trilafon;Trilifan;Chlorperphenazine;Perfenazine;Fentazine duolets;Fentazin syrup;Thilatazin;Tranquisan;Emesinal;Perphenan;PZC;Sch 3940;Triphenot;Chloriprozine;NSC 150866;Perfenil;Mutabom;PZC (tranquilizer);2-[4-[3-(2-Chloro-phenothiazin-10-yl)-propyl]-piperazin-1-yl]-ethanol;2-[4-[3-(2-Chlorophenothiazin-10-yl)propyl]piperazin-1-yl]ethanol;2-[4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]piperazin-1-yl]ethan-1-ol;8055-48-9
CAS No.:58-39-9
Molecular Formula:C21H26ClN3OS
InChIKeys:InChIKey=RGCVKNLCSQQDEP-UHFFFAOYSA-N
Molecular Weight:403.97
Exact Mass:403.97
EC Number:200-381-5
UNII:FTA7XXY4EZ
NSC Number:758649|150866
DSSTox ID:DTXSID1023441
NCI Thesaurus Code:C29355
Color/Form:Crystals|White to creamy-white powder
ATC Code:N - Nervous system
HScode:2934999090
Categories:
Characteristics-
PSA:
55.2
XLogP3:4.2
Appearance:Solid
Density:1.253
Melting Point:94-100 °C
Boiling Point:214-218 °C @ Press: 0.15 Torr
Flash Point:304.8±30.1 °C
Refractive Index:1.627
Water Solubility:28.28mg/L(24 ºC)
Storage Conditions:2-8°C
Vapor Pressure:7.52X10-12 mm Hg at 25 deg C (est)
Toxicity:Oral-Rat LD50: 318 mg/kg; Oral-Mouse LD50: 120 mg/kg
Flammability characteristics:Combustible, decomposes toxic chloride, sulfur oxide and nitrogen oxide gas when burning
Odor:Almost odorless
Taste:Bitter taste
PH:pH = 4.2 - 5.6
PKA:7.94None
Henrys Law Constant:Henry's law constant = 5.19X10-18 atm-cu m/mol at 25 °C (est)
Dissociation Constants:7.94|pKa = 7.94
Collision Cross Section:193.2 Ų [M+H]+ [CCS Type: TW, Method: Major Mix IMS/Tof Calibration Kit (Waters)]|192 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]
Experimental Properties:Osmolality of 5 mg/mL is 263 mOsm/kg|Sensitive to light
Hazard IdentificationClassification of the substance or mixture
Acute toxicity - Category 4, Oral
Skin sensitization, Category 1
GHS label elements, including precautionary statements
Pictogram(s)
Signal word Warning
Hazard statement(s) H302 Harmful if swallowed
H317 May cause an allergic skin reaction
Precautionary statement(s) Prevention P264 Wash ... thoroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response P301+P317 IF SWALLOWED: Get medical help.
P330 Rinse mouth.
P302+P352 IF ON SKIN: Wash with plenty of water/...
P333+P317 If skin irritation or rash occurs: Get medical help.
P321 Specific treatment (see ... on this label).
P362+P364 Take off contaminated clothing and wash it before reuse.
Storage none
Disposal P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.
Other hazards which do not result in classification
no data available
Handling and StoragePrecautions for safe handling
Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.
Conditions for safe storage, including any incompatibilities
Store in tight, light-resistant container as defined in the USP-NF. This material should be handled and stored per label instructions to ensure product integrity.
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Seller Information
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Business Type:
Trader
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Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements
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Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China
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Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance
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Average lead Time:
10 days
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Total Annual Revenue:
$5 million-$10 million
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Total Employees:
11-50
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Year of Establishment:
2013
Company Certificates-
Certification Report by Bureau Veritas
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Inquiry History3 Inquiries
Country Product Purchase Quantity Date Posted
India
Perphenazine
10 KG Jul 23, 2025
India
Perphenazine
50 KG May 23, 2026
India
Perphenazine USP
50 KG May 21, 2026 Post an enquiry for this product
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