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High Purity API 99% Antiviral Drug Velpatasvir CAS 1377049-84-7 GS-5816 with best price

Name: High Purity API 99% Antiviral Drug Velpatasvir CAS 1377049-84-7 GS-5816 with best price
Brand: HyperChem
Price: 5000 USD
Availability: InStock

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CAS No.:

1377049-84-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

1kg/Bag, 25kg/drum

Price valid (until):

2024-12-29

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Velpatasvir
CAS number	1377049-84-7
EINECS number	1592732-453-0
Synonym	GS5816; GS-5816; GS 5816; Velpatasvir; methyl ((R)-2-((2S,4S)-2-(5-(2-((2S,5S)-1-((methoxycarbonyl)-L-valyl)-5-methylpyrrolidin-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-9-yl)-1H-imidazol-2-yl)-4-(methoxymethyl)pyrrolidin-1-yl)-2-oxo-1-phenylethyl)carbamate; Epclusa; Sofosvel; Velpanat
Description	Velpatasvir, also known as GS-5816, is a potent and selective Hepatitis C virus NS5A inhibitor. GS-5816 has demonstrated pan-genotypic activity and a high barrier to resistance in HCV replicon assays. GS-5816 demonstrated pangenotypic antiviral activity in patients with genotype 1-4 HCV infection. It will be further evaluated in combination with other pangenotypic direct-acting antivirals to achieve the goal of developing a well-tolerated, highly effective treatment for all HCV genotypes.
Structure
Molecular Formula	C49H54N8O8
Molecular Weight	883 g/mol
Appearance	Solid powder
Quality Standard	Enterprise Standard
Assay	≥98%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Store in cool place. Keep container tightly closed in a dry and well ventilated place.
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Velpatasvir More Info

Velpatasvir is a direct-acting antiviral (DAA) medication primarily used in combination with sofosbuvir for the treatment of chronic hepatitis C virus (HCV) infection across all six major genotypes.

Mechanism of Action

Velpatasvir functions as an NS5A inhibitor, targeting the non-structural protein 5A (NS5A) of the HCV. This protein is crucial for viral replication and assembly. Velpatasvir binds to domain I of NS5A, inhibiting its function and thereby preventing the virus from replicating and assembling effectively . This mechanism contributes to its high barrier to resistance compared to earlier NS5A inhibitors like ledipasvir and daclatasvir

Applications

Velpatasvir is indicated for:
Treatment of chronic HCV genotypes 1 through 6.
Use in patients with compensated cirrhosis or those co-infected with HIV.
Combination therapy with ribavirin in cases of decompensated cirrhosis.

Routes of Administration

Velpatasvir is administered orally, typically in tablet form as part of the fixed-dose combination with sofosbuvir. The recommended dosage is usually once daily.

Safety and Side Effects

Common side effects associated with velpatasvir include:
Fatigue
Headache
Nausea
Insomnia
Diarrhea
In clinical trials, side effects occurred at similar frequencies to placebo groups, indicating a generally favorable safety profile. Serious adverse effects are rare, but monitoring is advised due to potential interactions with other medications.

Pharmacokinetics

Key pharmacokinetic properties of velpatasvir include:
Absorption: Oral bioavailability ranges from 25% to 30%.
Peak Plasma Concentration: Achieved approximately three hours post-administration.
Protein Binding: Over 99.5% bound to plasma proteins.
Metabolism: Primarily metabolized in the liver via CYP2B6, CYP2C8, and CYP3A4 enzymes.
Elimination Half-Life: Approximately 15 hours.
Excretion: About 94% is excreted via feces (77% as the parent compound), with only 0.4% eliminated through urine.

Drug Interactions

Velpatasvir can interact with various medications due to its role as both a substrate and an inhibitor of several drug transporters (e.g., P-glycoprotein). Significant interactions include:
Reduced efficacy when co-administered with strong inducers like rifampicin or certain anticonvulsants.
Increased concentrations of drugs such as digoxin when used concurrently.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Velpatasvir

Other Name:

Carbamic acid,N-[(1R)-2-[(2S,4S)-2-[5-[1,11-dihydro-2-[(2S,5S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methyl-1-oxobutyl]-5-methyl-2-pyrrolidinyl][2]benzopyrano[4′,3′:6,7]naphth[1,2-d]imidazol-9-yl]-1H-imidazol-2-yl]-4-(methoxymethyl)-1-pyrrolidinyl]-2-oxo-1-phenylethyl]-,methyl ester;Velpatasvir;GS 5816;Methyl [(2S)-1-[(2S,5S)-2-[9-[2-[(2S,4S)-1-[(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetyl]-4-(methoxymethyl)pyrrolidin-2-yl]-1H-imidazol-5-yl]-1,11-dihydroisochromeno[4′,3′:6,7]naphtho[1,2-d]imidazol-2-yl]-5-methylpyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate;1458063-71-2

CAS No.:

1377049-84-7

Molecular Formula:

C49H54N8O8

InChIKeys:

InChIKey=FHCUMDQMBHQXKK-CDIODLITSA-N

Molecular Weight:

883.019

Exact Mass:

883.00

UNII:

KCU0C7RS7Z

NCI Thesaurus Code:

C152851

ATC Code:

J05A

Categories:

Antivirals

Characteristics

PSA:

193

XLogP3:

6.2

Density:

1.314±0.06 g/cm3(Predicted)

See More Velpatasvir Properties 

Hazard Identification

Classification of the substance or mixture

no data available

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)	no data available
Signal word	no data available
Hazard statement(s)	no data available
Prevention	no data available
Response	no data available
Storage	no data available
Disposal	no data available

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Velpatasvir Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

10 Inquiries

Country	Product	Purchase Quantity	Date Posted
Russia	Velpatasvir	17.00 G	Aug 14, 2024
Russia	PRL-8-53	10.00 G	Aug 14, 2024
Russia	Sofosbuvir	68.00 G	Aug 14, 2024
Russia	Enclomiphene	100.00 G	Aug 14, 2024
Russia	7,8-Dihydroxyflavone	75.00 G	Aug 14, 2024
Russia	Citicoline sodium	750.00 G	Aug 14, 2024
Russia	NNMTi	15.00 G	Aug 14, 2024
Russia	Unifiram	30.00 G	Aug 14, 2024
Russia	Coluracetam	100.00 G	Aug 14, 2024
Russia	DIHEXA	50.00 G	Aug 14, 2024

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