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API Tigecycline CAS 220620-09-7

Name: API Tigecycline CAS 220620-09-7
Brand: Hyper Chem
SKU: pr2412061305
Price: 60 USD
Availability: InStock

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CAS No.:

220620-09-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-01-06

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Tigecycline
CAS number	220620-09-7
Synonym	GAR936; GAR-936; GAR936; Tigecycline; trade name: TYGACL.
Description	Tigecycline is a glycylcycline antibiotic developed by Francis Tally and marketed by Wyeth under the brand name Tygacil. It was given a U.S. Food and Drug Administration (FDA) fast-track approval and was approved on June 17, 2005. It was developed in response to the growing prevalence of antibiotic resistance in bacteria such as Staphylococcus aureus and Acinetobacter baumannii. The New Delhi metallo-β-Lactamase multidrug-resistant Enterobacteriaceae has also shown susceptibility to tigecycline.
Structure
Molecular Formula	C₂₉H₃₉N₅O₈
Molecular Weight	585.650
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Tigecycline More Info

Tigecycline is a broad - spectrum antibiotic.

1. Chemical structure and classification

Tigecycline belongs to the glycylcycline class of antibiotics. It is a derivative of minocycline. Structurally, it has modifications that give it enhanced antibacterial properties compared to traditional tetracyclines.

2. Mechanism of action

It inhibits bacterial protein synthesis. Tigecycline binds to the 30S ribosomal subunit of bacteria, preventing the binding of aminoacyl - tRNA to the A - site of the ribosome. This interference blocks the elongation step of protein synthesis. As a result, bacteria are unable to produce essential proteins needed for their growth, replication, and survival. This mechanism of action is similar to that of other tetracycline - based antibiotics, but tigecycline's binding affinity and antibacterial spectrum are broader in some respects.

3. Antibacterial spectrum

Tigecycline has a wide range of antibacterial activity. It is effective against many Gram - positive bacteria such as Staphylococcus aureus (including methicillin - resistant strains, MRSA), Streptococcus pneumoniae, and Enterococcus faecalis.

Against Gram - negative bacteria, it can act on Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. Additionally, it has activity against anaerobic bacteria like Bacteroides fragilis. However, it is not typically the first - line agent for treating infections caused by Pseudomonas aeruginosa, as this bacterium is generally less susceptible.

4. Clinical uses

Tigecycline is used to treat complicated skin and skin - structure infections. For example, in cases of deep - seated abscesses, infected ulcers, and cellulitis caused by susceptible bacteria.

It is also indicated for complicated intra - abdominal infections. In abdominal surgeries, if there is a post - operative infection involving the peritoneal cavity and the surrounding tissues, tigecycline can be a treatment option when the causative organisms are susceptible.

Community - acquired pneumonia caused by resistant bacteria is another area where tigecycline can play a role, especially when other antibiotics may not be effective due to resistance patterns.

5. Pharmacokinetics

Tigecycline is administered intravenously. After administration, it is widely distributed throughout the body, including in tissues such as the lungs, liver, and kidneys. It has a relatively long half - life, which allows for less - frequent dosing compared to some other antibiotics. The drug is mainly excreted via the biliary - fecal route, with a smaller portion excreted in the urine.

6. Side effects and precautions

Common side effects may include nausea, vomiting, and diarrhea. Some patients may also experience an increase in liver enzyme levels. There have been concerns about an increased risk of death when tigecycline is used to treat certain severe infections, although the exact nature of this risk and its relationship to the drug's use is still a subject of study.

Because of its broad - spectrum activity, tigecycline should be used with caution to avoid overuse and the development of resistance. Clinicians need to carefully consider the susceptibility of the infecting organisms and the patient's overall condition before prescribing tigecycline.

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Certificates

Basic Info

Product Name:

Tigecycline

Other Name:

2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)-;2-Naphthacenecarboxamide,4,7-bis(dimethylamino)-9-[[[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-,(4S,4aS,5aR,12aS)-;(4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[[2-[(1,1-dimethylethyl)amino]acetyl]amino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide;GAR 936;WAY-GAR 936;Tigecycline;Glycylcycline;Tygacil

CAS No.:

220620-09-7

Molecular Formula:

C29H39N5O8

InChIKeys:

InChIKey=FPZLLRFZJZRHSY-HJYUBDRYSA-N

Molecular Weight:

585.65

Exact Mass:

585.65

EC Number:

1308068-626-2

UNII:

70JE2N95KR

DSSTox ID:

DTXSID2048581

NCI Thesaurus Code:

C72865

Color/Form:

Orange powder or cake

ATC Code:

J01AA12|J - Antiinfectives for systemic use

HScode:

3004909090

Categories:

Antibiotics

Characteristics

PSA:

206

XLogP3:

1.1

Appearance:

Powder

Density:

1.5±0.1 g/cm3

Melting Point:

164-166°C

Boiling Point:

890.922°C at 760 mmHg

Flash Point:

492.6±34.3 °C

Refractive Index:

1.675

Water Solubility:

In water, 14.55 mg/L at 25 deg C (est)

Storage Conditions:

Amber Vial, -20°C Freezer

Vapor Pressure:

9.1X10-30 mm Hg at 25 deg C (est)

See More Tigecycline Properties 

Hazard Identification

Classification of the substance or mixture

Eye irritation, Category 2

Reproductive toxicity, Category 1B

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H319 Causes serious eye irritation H360 May damage fertility or the unborn child
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P203 Obtain, read and follow all safety instructions before use.
Response	P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Tigecycline Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Tigecylcine	100 KG	Sep 11, 2024
Pakistan	Tigecycline	5 KG	Sep 4, 2024

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