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High Quality 99% Ambrisentan CAS 177036-94-1 Powder Fast Shipping Good Price

Name: High Quality 99% Ambrisentan CAS 177036-94-1 Powder Fast Shipping Good Price
Brand: HyperChem
SKU: pr2412101046
Price: 130 USD
Availability: InStock

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CAS No.:

177036-94-1

Grade:

Pharmaceutical Grade

Content:

99.5%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/Bag

Price valid (until):

2025-01-10

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Ambrisentan
CAS number	177036-94-1
Synonym	BSF-208075; BSF208075; BSF 208075; LU-208075; LU208075; LU 208075; Ambrisentan
Description	Ambrisentan, also known as BSF-208075 and LU-208075, is a drug indicated for use in the treatment of pulmonary hypertension. Ambrisentan, which relaxes those muscles, is an endothelin receptor antagonist, and is selective for the type A endothelin receptor (ETA). Ambrisentan significantly improved exercise capacity (6-minute walk distance) compared with placebo in two double-blind, multicenter trials (ARIES-1 and ARIES-2). Ambrisentan was approved by the U.S. Food and Drug Administration (FDA) and European Medicines Agency, and designated an orphan drug, for the treatment of pulmonary hypertension.
Structure
Molecular Formula	C22H22N2O4
Molecular Weight	378.42 g/mol
Appearance	White powder
Quality Standard	99%
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 2~8 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag, Bottle
Commercial package	Aluminium Tin
Origin	China

Ambrisentan More Info

Introduction:

Ambrisentan is an oral medication primarily used in the treatment of pulmonary arterial hypertension (PAH), a condition characterized by high blood pressure in the arteries of the lungs. It belongs to a class of drugs known as endothelin receptor antagonists.

Mechanism of Action:

Ambrisentan works by specifically antagonizing the endothelin-1 receptor (ETA), which is a protein that binds to the endothelin-1 peptide. Endothelin-1 is a potent vasoconstrictor that causes narrowing of blood vessels and increases blood pressure. By blocking the effects of endothelin-1, ambrisentan leads to vasodilation (widening of blood vessels) in the pulmonary and systemic arterial circulation, ultimately reducing pulmonary artery pressure and improving exercise capacity in patients with PAH.

Indications:

Ambrisentan is indicated for:

Pulmonary Arterial Hypertension (PAH) : It is used to improve exercise ability and delay clinical worsening in patients with PAH.

Dosage and Administration:

Ambrisentan is typically administered orally in tablet form. The usual starting dose may be adjusted based on clinical response and tolerance. It is important to follow the prescribing healthcare provider’s instructions for dosage and frequency.

Side Effects:

Common side effects associated with ambrisentan may include:

Peripheral edema (swelling in the extremities)

Headache

Flushing

Nasal congestion

Anemia

Serious side effects can occur, including liver function abnormalities and elevated liver enzymes, which may require periodic monitoring.

Precautions:

Liver Function: Patients with pre-existing liver conditions or elevated liver enzymes should be monitored closely, and dosage adjustments may be necessary.

Pregnancy: Ambrisentan is contraindicated during pregnancy due to potential risks to fetal development. Effective contraception is advised for women of childbearing potential.

Drug Interactions: Ambrisentan may interact with other medications that affect liver enzymes, so it is important to inform healthcare providers of all medications being taken.

Conclusion:

Ambrisentan is an effective treatment for pulmonary arterial hypertension, providing significant benefits in reducing symptoms and improving quality of life for patients. Its targeted action on endothelin receptors offers a valuable therapeutic option, but careful monitoring of liver function and other precautions is necessary to ensure safe use. Always consult healthcare providers for personalized treatment plans and guidance.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders:
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

ECHEMI Editorial Reference

White to Off White SolidAmbrisentan is a selective endothelin-A (ETA) receptor antagonist introduced for the oral treatment of patients with pulmonary arterial hypertension (PAH), to improve exercise capacity and delay clinical worsening. It is the third ET-receptor antagonist to be marketed for this indication behind bosentan and sitaxsentan. PAH is a rare disease of the small pulmonary arteries characterized by vascular proliferation and remodeling, resulting in a progressive increase in

Certificates

Basic Info

Product Name:

Ambrisentan

Other Name:

Benzenepropanoic acid,α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-,(αS)-;Benzenepropanoic acid,α-[(4,6-dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenyl-,(S)-;(αS)-α-[(4,6-Dimethyl-2-pyrimidinyl)oxy]-β-methoxy-β-phenylbenzenepropanoic acid;Ambrisentan;BSF 208075;LU 208075;Letairis;Volibris;(+)-(2S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropanoic acid;(2S)-2-(4,6-Dimethylpyrimidin-2-yl)oxy-3-methoxy-3,3-diphenylpropanoic acid

CAS No.:

177036-94-1

Molecular Formula:

C22H22N2O4

InChIKeys:

InChIKey=OUJTZYPIHDYQMC-LJQANCHMSA-N

Molecular Weight:

378.42

Exact Mass:

378.42

EC Number:

1308068-626-2

HScode:

29335990

Categories:

Other Chemical Drugs

Characteristics

PSA:

81.5

XLogP3:

3.8

Density:

1.228±0.06 g/cm3(Predicted)

Melting Point:

>150°C (dec.)

Boiling Point:

551.1±60.0 °C(Predicted)

Flash Point:

287.1ºC

Refractive Index:

1.593

Water Solubility:

Ambrisentan is practically insoluble in aqueous solutions at low pH. Solubility increases at higher pH.

Storage Conditions:

-20°C Freezer

Vapor Pressure:

5.56E-13mmHg at 25°C

See More Ambrisentan Properties 

Hazard Identification

Classification of the substance or mixture

Carcinogenicity, Category 2

Reproductive toxicity, Category 1A

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H351 Suspected of causing cancer H360 May damage fertility or the unborn child
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P318 IF exposed or concerned, get medical advice.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Ambrisentan Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Ambrisentan	150 G	Dec 20, 2024

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High Quality 99% Ambrisentan CAS 177036-94-1 Powder Fast Shipping Good Price

Product Description

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