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API Elagolix Sodium

Name: API Elagolix Sodium
Brand: Hyper Chem
SKU: pr2412131581
Price: 130 USD
Availability: InStock

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CAS No.:

1192491-61-4

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-01-13

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Elagolix Sodium
CAS number	832720-36-2
Related CAS	834153-87-6 (free acid) 832720-36-2 (sodium)
Synonym	NBI56418 Na; NBI-56418; NBI 56418; ABT-620; ABT 620; ABT620; Elagolix sodium; Orilissa;
Description	Elagolix, also known as NBI56418 and ABT-620, is a Gonadotropin-Releasing Hormone (GnRH) Antagonist. Elagolix inhibits gonadatropin releasing hormone (GnRH) receptors in the pituitary gland and ultimately reduces circulating sex hormone levels. Elagolix is believed to have its effect by altering the level of pituitary GnRH suppression and, as a result, titrating circulating estrogen levels. Elagolix was approved in 2018.
Structure
Molecular Formula	C₃₂H₂₉F₅N₃NaO₅
Molecular Weight	653.570
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Elagolix sodium More Info

1. General information

Elagolix sodium is a drug substance. Chemically, it is a small - molecule gonadotropin - releasing hormone (GnRH) antagonist. The molecular formula of elagolix sodium is C₃₂H₂₉F₃N₃NaO₄ and its molecular weight is approximately 603.57 g/mol.

2. Mechanism of action

It works by blocking the GnRH receptors in the pituitary gland. GnRH is a hormone that normally stimulates the release of luteinizing hormone (LH) and follicle - stimulating hormone (FSH) from the pituitary. By blocking this receptor, elagolix sodium reduces the secretion of LH and FSH. As a result, it suppresses the production of estrogen in women and testosterone in men.

For example, in women with endometriosis, this suppression of ovarian steroidogenesis can help in reducing the growth and activity of endometrial - like tissue outside the uterus, which is a characteristic of endometriosis.

3. Indications

Elagolix sodium is mainly indicated for the management of pain associated with endometriosis. Endometriosis is a condition in which the tissue similar to the lining of the uterus (endometrium) grows outside the uterus, such as on the ovaries, fallopian tubes, or other pelvic organs. The abnormal growth of this tissue can cause chronic pelvic pain, painful periods, and pain during sexual intercourse.

It can also be used in the treatment of uterine fibroids - non - cancerous growths that develop in or on the uterus. By reducing the hormonal stimulation, it may help in controlling the symptoms related to fibroids such as heavy menstrual bleeding and pelvic pressure.

4. Dosage and administration

The dosage of elagolix sodium depends on the specific indication and the patient's response. It is usually available in the form of tablets and is taken orally. For endometriosis, typical dosages may range from a certain amount per day over a period of months.

It's important that patients take the medication as prescribed by their healthcare provider. Skipping doses or taking incorrect amounts can affect the drug's efficacy and may lead to a recurrence of symptoms or other potential side effects.

5. Side effects

Common side effects may include hot flashes, night sweats, headache, and decreased bone mineral density. The decrease in bone mineral density is a concern because long - term use of drugs that suppress sex hormones can have an impact on bone health.

Other possible side effects can involve changes in mood such as depression or anxiety, nausea, and changes in menstrual patterns. For example, women may experience irregular bleeding or amenorrhea (absence of menstruation) during treatment.

6. Precautions and contraindications

It is not recommended for use in women who are pregnant as it can harm the developing fetus due to its hormonal - modulating effects. There is also a risk of osteoporosis with long - term use, so patients' bone health needs to be monitored.

In patients with a history of depression or other mood disorders, careful consideration should be given before prescribing elagolix sodium, as it may exacerbate these conditions.

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ECHEMI Editorial Reference

Avibactam sodium (NXL-104), a diazabicyclooctanone compound, is currently the most favoured novel β-lactamase inhibitor. Compared with the three marketed β-lactamase inhibitors, NXL-104 has a long duration of action and reversible covalent binding to the enzyme, and does not induce β-lactamase production.
Avibactam sodium and its free acid, avibactam, are diazabicyclooctane (DBO)–based, non-β-lactam β-lactamase inhibitors (BLIs) that are used to treat multi-drug–resistant Gram-negative bacterial pathogens. The compounds were jointly developed by Actavis Generics (now part of Teva Pharmaceutical Industries) and AstraZeneca.In 2015, avibactam sodium, in combination with ceftazidime, a cephalosporin antibiotic, was approved by the US Food and Drug Administration. The dual-drug’s target was complex urinary tract and intra-abdominal infections caused by Gram-negative, often hospital-acquired, bacteria.In 2018, in the continuing quest to combat multi-drug–resistant bacteria, Eric M. Gordon, Matthew A. J. Duncton, and Mark A. Gallop at Arixa Pharmaceuticals (Palo Alto, CA) prepared analogues of avibactam that are more orally available than the free acid or its salt.
ChEBI: Avibactam sodium is an organic sodium salt that is the monosodium salt of avibactam. Used in combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis. It has a role as an EC 3.5.2.6 (beta-lactamase) inhibitor, an antibacterial drug and an antimicrobial agent. It contains an avibactam(1-).

Certificates

Basic Info

Product Name:

Avibactam sodium

Other Name:

AvibactaM SodiuM Salt;NXL 104;Sulfuric Acid Mono[(1R,2S,5R)-2-(aMinocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] Ester SodiuM Salt;Avibactam (sodium);AvibactaM SodiuM NXL 104;sodium (1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl sulfate;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide monosodium salt;(2S,5R)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide 7-oxo-6-(sulfoxy)monosodium salt

CAS No.:

1192491-61-4

Molecular Formula:

C7H11N3O6S.Na

InChIKeys:

JKMUNBAKQJMVKG-NLZGLQCHNA-N

Molecular Weight:

288.23

Color/Form:

White to Off-White

Categories:

Inhibitor Drugs

Characteristics

Melting Point:

>208°C (dec.)

Water Solubility:

H2O: 2mg/mL, clear

Critical Temperature & Pressure:

Sealed in dry,Room Temperature

See More Avibactam sodium Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Storage	none
Disposal	none

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Avibactam sodium Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

1 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Avibactam Sodium	1 KG	Jan 13, 2024

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