High Quality Pharmaceutical Raw Powder Rifaximin CAS 80621-81-4 with best price and fast delivery

Rifaximin More Info

Rifaximin is a broad-spectrum, non-systemic antibiotic primarily used for gastrointestinal conditions. It is a structural analog of rifampin and is notable for its minimal absorption in the gastrointestinal tract, allowing it to exert localized effects.

Mechanism of Action

Rifaximin functions by inhibiting bacterial RNA synthesis. It binds to the beta-subunit of bacterial DNA-dependent RNA polymerase, blocking the transcription process and thereby preventing bacterial growth. Its multifaceted mechanism includes:
Direct Antimicrobial Effects: Inhibits RNA synthesis in susceptible bacteria.
Inhibition of Bacterial Translocation: Reduces the adherence of bacteria to intestinal epithelial cells, which decreases the risk of infection and inflammation.
Modulation of Gut Immune Signaling: Activates the pregnane X receptor (PXR), which helps reduce pro-inflammatory responses in conditions like inflammatory bowel disease (IBD).

Applications

Rifaximin is indicated for several gastrointestinal disorders, including:
Irritable Bowel Syndrome with Diarrhea (IBS-D): Helps alleviate symptoms by restoring gut flora balance.
Hepatic Encephalopathy: Prevents recurrence by reducing ammonia-producing bacteria in patients with liver disease.
Traveler's Diarrhea: Treats diarrhea caused by non-invasive strains of E. coli.
Small Intestinal Bacterial Overgrowth (SIBO): Effective in managing symptoms related to excessive bacterial growth in the small intestine.
Crohn’s Disease: Used as an adjunct therapy for managing flare-ups.

Routes of Administration

Rifaximin is administered orally and is available in tablet form. It is recommended to take it without regard to meals to maintain consistent absorption levels.

Safety and Side Effects

Rifaximin is generally well-tolerated, but it can cause side effects, including:
Common Side Effects:
Nausea
Abdominal pain
Headache
Dizziness
Fatigue
Serious Side Effects:
Watery or bloody diarrhea, which may occur months after treatment.
Allergic reactions such as hives, swelling, or difficulty breathing.
Severe skin reactions like Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported, particularly in patients with liver disease.

Pharmacokinetics

Rifaximin exhibits unique pharmacokinetic properties:
Absorption: It has very low systemic absorption; approximately 80% to 90% remains in the gut after oral administration, with less than 0.2% entering systemic circulation.
Distribution: Due to its poor absorption, rifaximin primarily acts locally within the gastrointestinal tract.
Metabolism: Minimal hepatic metabolism occurs; it does not significantly inhibit or induce cytochrome P450 enzymes at therapeutic doses.
Half-life: The elimination half-life ranges from approximately 5 to 6 hours.
Excretion: The drug is predominantly excreted unchanged in feces, with less than 0.4% eliminated through urine.

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FAQ

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Suitable for more than 50kg 
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For sample orders: 
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2. Packaging photo
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For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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