Trimebutine maleate CAS 34140-59-5 purity: 98%

Trimebutine maleate More Info

Trimebutine maleate is a pharmaceutical compound primarily used in the treatment of functional gastrointestinal disorders, particularly irritable bowel syndrome (IBS). It has been in use since the late 1960s and is recognized for its multifaceted pharmacological properties, making it effective in managing various gastrointestinal symptoms.

Mechanism of Action

Trimebutine exerts its effects through several mechanisms:
Opiate Receptor Agonism: It acts as an agonist on peripheral mu, kappa, and delta opiate receptors, which helps in modulating pain and gastrointestinal motility.
Gastrointestinal Peptide Modulation: Trimebutine influences the release of various gastrointestinal peptides, including motilin, vasoactive intestinal peptide, gastrin, and glucagon, which are crucial for digestive processes.
Motor Activity Regulation: It accelerates gastric emptying and induces phase III of the migrating motor complex in the intestines, while also modulating colonic contractility. This dual action allows it to alleviate both constipation and diarrhea associated with IBS.

Applications

Irritable Bowel Syndrome (IBS): It effectively relieves symptoms such as abdominal pain, cramps, and irregular bowel movements.
Functional Gastrointestinal Disorders: Used to treat various conditions characterized by gastrointestinal discomfort and dysmotility.
Postoperative Recovery: It can aid in restoring normal gut motility after surgical procedures.

Routes of Administration

Trimebutine maleate is typically administered orally in tablet form. The usual dosage ranges from 300 to 600 mg per day, divided into multiple doses based on individual patient needs.