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API Lenalidomide

Name: API Lenalidomide
Brand: Hyper Chem
SKU: pr2501071289
Price: 7 USD
Availability: InStock

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CAS No.:

191732-72-6

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-02-07

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information

Description

Name	Lenalidomide
CAS number	191732-72-6
Synonym	CC5013; CC-5013; CC 5013; IMiD1; Lenalidomide; US brand name: Revlimid.
Description	Lenalidomide, also known as CC-5013, is the thalidomide analog with potential antineoplastic activity. Lenalidomide inhibits TNF-alpha production, stimulates T cells, reduces serum levels of the cytokines vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), and inhibits angiogenesis. This agent also promotes G1 cell cycle arrest and apoptosis of malignant cells. Lenalidomide is an approved drug.
Structure
Molecular Formula	C₁₃H₁₃N₃O₃
Molecular Weight	259.260
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Lenalidomide More Info

Lenalidomide is a drug that has had a significant impact in the field of medicine, especially in the treatment of certain cancers and blood disorders.

1. Chemical and Pharmacological Properties

Chemical Structure: Lenalidomide is a derivative of thalidomide. It has a more complex molecular structure that is designed to have enhanced therapeutic effects while minimizing some of the severe side - effects associated with its predecessor. The chemical formula of lenalidomide is .

Mechanism of Action: It works through multiple mechanisms. One of the key ways it functions is by modulating the immune system. It enhances the activity of T - cells and natural killer (NK) cells, which are important components of the body's immune defense. Additionally, it has anti - angiogenic properties, meaning it can inhibit the formation of new blood vessels that tumors need to grow and spread. For example, in multiple myeloma, it disrupts the interaction between the myeloma cells and the bone marrow microenvironment, which is crucial for the survival and proliferation of the cancer cells.

2. Medical Uses

Multiple Myeloma: It is a cornerstone of treatment for multiple myeloma. In combination with other drugs such as dexamethasone, it can significantly increase the survival rate and the time to disease progression. Clinical trials have shown that patients treated with lenalidomide - based regimens have better responses compared to those treated with traditional chemotherapy alone.

Myelodysplastic Syndromes (MDS): Lenalidomide is also used to treat certain subtypes of MDS. It can improve the quality of blood cells and reduce the need for blood transfusions in patients. For example, in patients with MDS - associated anemia, it can stimulate the production of healthy red blood cells.

Marginal Zone Lymphoma: In some cases, it is used for the treatment of marginal zone lymphoma. It helps in reducing the tumor burden and improving the overall condition of the patients.

3. Side Effects and Precautions

Common Side Effects: The most common side effects include fatigue, neutropenia (a reduction in the number of neutrophils, a type of white blood cell), thrombocytopenia (a low platelet count), and diarrhea. These side effects can usually be managed with dose adjustments and supportive care.

Teratogenicity: Given its origin related to thalidomide, lenalidomide is highly teratogenic. This means it can cause severe birth defects. Therefore, strict measures such as pregnancy prevention programs are implemented for patients taking this drug. Female patients of child - bearing age must use two forms of effective birth control during treatment and for a period after treatment.

4. Regulatory and Approval Status

Lenalidomide has been approved by major regulatory agencies such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA). However, its use is closely monitored due to its potential side effects and the need to ensure that it is prescribed appropriately according to the patient's condition and the specific requirements of the treatment protocol.

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Certificates

Basic Info

Product Name:

Lenalidomide

Other Name:

2,6-Piperidinedione,3-(4-amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-;3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione;Revimid;CC 5013;CDC 501;Lenalidomide;Revlimid;1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole;3-(4-Amino-1-oxoisoindolin-2-yl)piperidin-2,6-dione;ENMD 0997;IMiD 3;revlMiD;346670-73-3;443912-14-9;824975-68-0

CAS No.:

191732-72-6

Molecular Formula:

C13H13N3O3

InChIKeys:

InChIKey=GOTYRUGSSMKFNF-UHFFFAOYSA-N

Molecular Weight:

259.26062

Exact Mass:

259.26

EC Number:

1308068-626-2

NSC Number:

747972

DSSTox ID:

DTXSID8046664

Color/Form:

Off-white to pale-yellow solid powder

ATC Code:

L04AX04|L04AX|L - Antineoplastic and immunomodulating agents

HScode:

29339900

Categories:

Antineoplastic Agents

Characteristics

PSA:

92.5

XLogP3:

-0.5

Appearance:

Solid

Density:

1.460±0.06 g/cm3(Predicted)

Melting Point:

269-271°C

Boiling Point:

614.0±55.0 °C(Predicted)

Flash Point:

325.1±31.5 °C

Refractive Index:

1.672

Water Solubility:

soluble in organic solvent/water mixtures, and buffered aqueous solvents. Lenalidomide is more soluble in organic solvents and low pH solutions. Solubility was significantly lower in less acidic buffers, ranging from about 0.4 to 0.5 mg/mL.

Storage Conditions:

-20°C Freezer

Vapor Pressure:

1.78X10-13 mm Hg at 25 deg C (est)

Specific rotation:

Has an asymmetric carbon atom and can exist as the optically active forms S(-) and R(+), and is produced as a reacemic mixture with a net optical rotation of zero

Henrys Law Constant:

Henry's law constant = 1.26X10-17 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa1 = 2.31 (primary amine); pKa2 = 11.61 (secondary amine) (est)

See More Lenalidomide Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H360 May damage fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Lenalidomide Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.
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