High Quality 98% White Powder Vildagliptin CAS 274901-16-5 with ready stock and fast delivery

Vildagliptin More Info

Vildagliptin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. It belongs to a class of medications known as dipeptidyl peptidase-4 (DPP-4) inhibitors, which work by enhancing the body's natural ability to lower blood sugar levels.

Mechanism of Action

Vildagliptin functions primarily through the inhibition of the DPP-4 enzyme, which is responsible for the degradation of incretin hormones, specifically glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). By inhibiting DPP-4, vildagliptin leads to:
Increased Levels of GLP-1 and GIP: This results in enhanced insulin secretion from pancreatic beta cells in response to meals, while also suppressing glucagon release from alpha cells, thereby reducing hepatic glucose production.
Improved Glycemic Control: The increased levels of these incretin hormones help to lower fasting and postprandial blood glucose levels without causing significant hypoglycemia, as their action is glucose-dependent.

Applications

Vildagliptin is indicated for:
Type 2 Diabetes Management: It is used as monotherapy or in combination with other antidiabetic medications, including metformin and sulfonylureas, to improve glycemic control.
Preservation of Beta-cell Function: Clinical studies suggest that vildagliptin may help maintain beta-cell function over time in patients with type 2 diabetes.

Routes of Administration

Vildagliptin is available in oral tablet form and is typically taken once or twice daily, depending on the prescribed regimen. It can be used alone or in combination with other antidiabetic agents.

Safety and Side Effects

Common Side Effects
Patients taking vildagliptin may experience:
Nausea
Headache
Dizziness
Diarrhea
Upper respiratory tract infections
Serious Side Effects
More severe adverse effects can include:
Pancreatitis: Symptoms may include severe abdominal pain that may radiate to the back.
Angioedema: Rare but serious allergic reactions characterized by swelling of the face, tongue, or throat.
Liver Dysfunction: Elevated liver enzymes may indicate potential liver problems; monitoring is recommended.

Pharmacokinetics

Absorption and Distribution
Vildagliptin is rapidly absorbed after oral administration, with peak plasma concentrations occurring within 1–2 hours. It has a bioavailability of approximately 85%.
Metabolism and Excretion
The drug is primarily metabolized by the liver via cytochrome P450 enzymes (CYP3A4 and CYP2C8) and excreted through urine. The elimination half-life is about 2–3 hours.
Special Considerations
Vildagliptin does not require dosage adjustments for renal impairment; however, caution is advised when used in patients with moderate to severe renal dysfunction.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.