Pnpg; 4-Nitrophenyl β -D-Glucopyranoside; 2492-87-7; P-Nitrophenyl β -D-Glucopyranoside

1. Basic information

Molecular formula: C12H15NO8

Molecular weight: 301.25

English name: 4-Nitrophenyl - β - D-glucopyranoside

Chemical structure: Glucose is linked to 4-nitrophenyl via a β - D-pyranose glycosidic bond.

2. Physical properties

Appearance: White crystalline powder.

Melting point: 200-202 ° C.

Solubility: Low solubility in water, increased solubility in hot water. Soluble in some organic solvents, such as dimethyl sulfoxide (DMSO), N, N-dimethylformamide (DMF), etc. The solubility also increases in alkaline solutions.

3. Chemical properties

Glycoside hydrolysis: Under acidic conditions, the glycosidic bond between glucose and 4-nitrophenyl is prone to hydrolysis, resulting in the formation of glucose and 4-nitrophenol. This reaction is an important foundation for enzyme catalyzed reaction research. For example, when studying glucosidase activity, the enzyme catalyzes this hydrolysis reaction, and the activity of the enzyme is measured by detecting the amount of 4-nitrophenol (4-NP) generated. 4-NP appears yellow under alkaline conditions (pH>10) and can be detected by spectrophotometry at wavelengths of 405-410nm.

Reactivity of nitro group: The nitro group in the 4-nitrophenyl moiety has certain chemical activity. Nitro groups can be reduced to amino groups through chemical reduction methods, such as using lithium aluminum hydride, iron/hydrochloric acid, etc., to obtain 4-aminophenyl - β - D-glucopyranoside. This reduction product may have potential applications in fields such as drug synthesis and biomarkers.

Preserving the chemical properties of sugar: The glucose portion still retains some of the chemical properties of sugar. For example, it can participate in some derivatization reactions of sugars, such as acetylation, methylation, etc. These reactions can be used to modify the structure of sugars and further study their biological activity and function.

4. Purpose

Enzymatic research: It is an excellent substrate for glucosidase (such as β - D-glucosidase). It is widely used in enzyme activity detection, enzyme kinetics research, and enzyme inhibitor screening. For example, when studying glucosidase in microorganisms or plant tissues, the activity of the enzyme is determined by detecting the amount of hydrolysis product 4-nitrophenol.

Drug development and screening: In the field of drug development, it is used to screen drugs that can regulate glucosidase activity. Many diseases (such as some cancers, diabetes, etc.) are related to the abnormal activity of glucosidase, so screening such drugs has important therapeutic significance.

Glycobiology research: In glycobiology research, it can be used to study the interactions between sugars and proteins or other biomolecules. For example, by modifying 4-nitrophenyl - β - D-glucopyranoside and studying its specific binding to sugar binding proteins, we can understand the role of sugar in cell recognition, signal transduction, and other processes.

Packaging Details: 25 kg/bag or as your requirement.
Port: Tianjin/ Qingdao/ Shanghai, etc.
We can ship the samples by air.
Lead Time: Within 15days after receiving the advance payment or original L/C.

XI'AN YI HANG CHEMICAL CO.,LTD was founded in 2002, located in xian City, shannxi, China. We are the high-tech chemical enterprise which specialized in researching, manufacturing and trading for chemical raw materials ,our products widely used in paints, textile, rubber, leather, plastic and so on.

With many years development and operation,we have become the group company for chemical production,we have the owned factory for produce stable quality products with high performance, and the advanced lab to ensure the best quality of each batch products.

We have our strictly quality control in our production, and we have passed ISO9001:2015 Quality Management System Certification and ISO14001 Environment Management System Certification.

Our main products includes Titanium Dioxide, Lithopone, Iron Oxide series, Chrome Oxide Green, Zinc Oxide, Carbon Black, STPP, SHMP, Oxalic Acid, DOP, SLES, and so on.

Q1: Are you manufacturer or trading company?

A1:Manufacturer.

Q2: Can I get some sample?
A2: Yes, usually 10-25g sample for free.

Q3: Is there a discount?
A3: Of course, welcome to contact us. Price would be different based on different quantity. For bulk
quantity, we will have discount for you.

Q4: How long for production and delivery?
A4: Most products we have in stock, sent time:Within 1-3 business days after received payment. Customized products further discussed.

Q5: Do you accept ODM or OEM service?
A5: Yes,we accept ODM and OEM services, ranges: Soft gel, Capsule, Tablet, Sachet, Granule,Private Label service, etc. Please contact us to design your own brand product.

Q6: How to deliver the goods?
A6: ≤50kg ship by FedEx or DHL etc, ≥50kg ship by Air, ≥100kg can be shipped by Sea. If you have special request on delivery, please contact us.

Q7: How to start orders or make payments?
A7:There are two ways for you to confirm order:
1. Proforma invoice with our company bank details will be sent to you once the order confirmed by Email. Pls arrange payment by TT. Goods will be sent after received payment within 1-3 business days.
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