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API Dihydroberberine

Name: API Dihydroberberine
Brand: Hyper Chem
SKU: pr2503241118
Price: 100 USD
Availability: InStock

4 Inquiries

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CAS No.:

483-15-8

Grade:

Pharmaceutical Grade

Content:

99%

Port:

shanghai

Brand:

Hyper Chem

Packaging:

20kg/Drum 25kg/Drum

Price valid (until):

2025-04-24

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Dihydroberberine
CAS number	483-15-8
Synonym	Dihydroberberine; Dihydroberberine; Dihydroumbellatine; NSC 331264
Description	Dihydroberberine is a derivative of Berberine -- an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2).
Molecular Formula	C₂₀H₁₉NO₄
Molecular Weight	337.370
Appearance	Solid powder
Quality Standard	USP, EP, BP, CP
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0 – 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Dihydroberberine More Info

Properties

It is a yellow - brown powder. It has better solubility in some organic solvents compared to berberine.

Biological Activities

Antibacterial Activity: Similar to berberine, dihydroberberine also shows certain antibacterial effects. It can inhibit the growth and reproduction of some pathogenic bacteria by interfering with the metabolic processes of bacteria.

Antidiabetic Effect: Studies have found that dihydroberberine has hypoglycemic effects. It can improve insulin sensitivity, regulate glucose metabolism, and thus play a role in the treatment and prevention of diabetes and its complications. The specific mechanism may be related to the regulation of related signaling pathways in cells.

Lipid - Lowering Effect: It can also regulate lipid metabolism, reduce the levels of triglycerides, total cholesterol, and low - density lipoprotein cholesterol in the blood, and increase the level of high - density lipoprotein cholesterol, which is beneficial for preventing and treating hyperlipidemia and related cardiovascular and cerebrovascular diseases.

Pharmacokinetics

Absorption: After oral administration, dihydroberberine is absorbed to a certain extent in the gastrointestinal tract. However, its absorption rate is affected by many factors, such as the form of the drug, the presence of other substances in the digestive tract, and individual differences.

Distribution: It can be distributed to various tissues and organs in the body, including the liver, kidney, heart, and brain. It has a certain ability to cross the blood - brain barrier and play a role in the central nervous system.

Metabolism: In the body, dihydroberberine is mainly metabolized by the liver through various enzymatic reactions, and the metabolites are excreted through urine and feces.

Advantages over Berberine

Higher Bioavailability: The reduced structure of dihydroberberine leads to better solubility and permeability, resulting in higher bioavailability compared to berberine. This means that it can achieve better therapeutic effects at lower doses, reducing the risk of side effects caused by high - dose administration.

Better Stability: Dihydroberberine has better chemical stability in some environments, which is beneficial for the preparation and storage of drugs. It is less likely to be affected by factors such as light, heat, and oxygen, thereby ensuring the effectiveness and quality of the drug.

In summary, dihydroberberine has important biological activities and potential applications in the medical field. Due to its better pharmacological properties than berberine, it has received increasing attention. However, further research is still needed to fully understand its mechanism of action, optimize the dosage and administration method, and evaluate its long - term safety and efficacy.

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Basic Info

Product Name:

Dihydroberberine

Other Name:

6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine,5,8-dihydro-9,10-dimethoxy-;Berbine,13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-;Berberine,dihydro-;5,8-Dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine;Dihydroberberine;7,8-Dihydroberberine;Dihydroumbellatine;NSC 331264;858716-33-3

CAS No.:

483-15-8

Molecular Formula:

C20H19NO4

InChIKeys:

InChIKey=FZAGOOYMTPGPGF-UHFFFAOYSA-N

Molecular Weight:

337.375

Exact Mass:

337.37

NSC Number:

331264

DSSTox ID:

DTXSID70197476

HScode:

2934999090

Categories:

Plant Extracts

Characteristics

PSA:

40.2

XLogP3:

5.09

Appearance:

Solid

Density:

1.4±0.1 g/cm3

Melting Point:

223-224 °C (decomp)

Boiling Point:

557.8±50.0 °C at 760 mmHg

Flash Point:

170.7±27.3 °C

Refractive Index:

1.679

Vapor Pressure:

1.77E-12mmHg at 25°C

See More Dihydroberberine Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 2, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H300 Fatal if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Dihydroberberine Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	dihydroberberine, Dihydroberberine, Dihydroumbellatine 98% white powder 483-15-8 Senwayer	1 KG	Oct 23, 2023
United States	Dihydroberberine	250 G	Aug 15, 2025
United States	Dihydroberberine	500 KG	May 9, 2025
United States	Dihydroberberine	1 KG	Mar 23, 2025

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