Pharma Grade USP Oseltamivir

CAS Number :196618-13-0
English name :Oseltamivir
English alias :TAMIFLU (3R,4R,5S)-Ethyl4-acetamido-5-amino-3-(pentan-3-yloxy)cyclohex-1-enecarboxylate; TaMvir; GS4104; Ostavir; GOP-A-Flu; OseltaChemicalbookmivr; OSELTAMIVIR; OSTELTAMIVIR; TaMiflu-Free
Chinese name: Oseltamivir
Chinese alias: Duffy Osemiway Oseltamivir Oseltamivir Oseltamivir intermediate Oseltamivir phosphate
CBNumber:CB1472402
Molecular formula :C16H28N2O4
Molecular weight :312.4
Chemical properties of oseltamivir
Melting point :107-108°C
Boiling point :473.3±45.0°C(Predicted)
Density :1.08±0.1g/cm ³ (Predicted)
Storage conditions :2-8°C(Protected fromlight)
Acidity coefficient (pKa):7.7(25°) 6.6 (70 °)
Form :Solid
Color: Off-white Topale Beige
Stability :Hygroscopic
CAS Database :196618-13-0
oseltamivirphosphate, an anti-influenza drug, was launched in 1999 as a neuraminidase inhibitor. Its trade name is Tamiflu(also known as "Tamiflu"). It was first discovered by GileadSciences and then jointly developed with Roche and approved for marketing in the United States. Oseltamivir phosphate is the first orally effective neuraminidase inhibitor drug, which is Chemicalbook effective against both influenza A and B viruses. After oral administration of oseltamivir, it is rapidly catalyzed by liver and intestinal esterases into its active metabolite, oseltamivir carboxylic acid. The configuration of oseltamivir carboxylic acid is similar to the transition state of neuraminidase and can competitive bind to the active site of influenza virus neuraminidase (NA). Therefore, it is a potent and highly selective influenza virus NA inhibitor (NAIs). It mainly reduces the spread of influenza A or B viruses by interfering with the release of the virus from infected host cells. Therefore, oseltamivir phosphate belongs to precursor drugs.

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