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Tafluprost More Info

What is Tafluprost?

Tafluprost is an ophthalmic (eye) medication used to reduce elevated intraocular pressure (IOP), which is the pressure inside the eye. It is commonly used in the treatment of conditions such as open-angle glaucoma and ocular hypertension. Tafluprost belongs to a class of drugs known as prostaglandin analogues.

Brand Names:

Tafluprost is marketed under the brand name:

Zioptan® (United States)

Saflutan® (Europe and other countries)

Mechanism of Action:

Tafluprost is a prostaglandin F2α analogue. It works by increasing the outflow of aqueous humor (the fluid inside the eye), primarily through the uveoscleral pathway, thereby lowering intraocular pressure. Elevated IOP is a major risk factor for glaucoma-related optic nerve damage and vision loss, so Tafluprost helps prevent further damage by maintaining a healthier level of pressure inside the eye.

Indications (Uses):

Tafluprost is used in adults for:

The reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

It may be used as monotherapy or in combination with other IOP-lowering medications such as beta-blockers.

Dosage and Administration:

Tafluprost comes as a 0.0015% ophthalmic solution.

The recommended dose is one drop in the affected eye(s) once daily in the evening.

Do not exceed once-daily dosing, as more frequent administration may reduce the IOP-lowering effect.

If you use other topical eye medications, you should wait at least 5 minutes between applying each product.

Special note: Tafluprost is often available in preservative-free, single-dose containers, which is especially beneficial for patients sensitive to preservatives or those with dry eyes.

Side Effects:

Common side effects include:

Eye redness (conjunctival hyperemia)

Eye irritation (burning or stinging)

Eyelash growth

Darkening of the eyelashes

Eye itching or discomfort

Increased pigmentation (color) of the iris (permanent)

Dry eyes

Less common but potential serious side effects:

Changes in the eyelids (e.g., darkening of the skin)

Intraocular inflammation (e.g., uveitis)

Macular edema (particularly in patients with risk factors such as aphakia)

Warnings and Precautions:

Iris and eyelash changes: May cause gradual and permanent discoloration of the iris (usually brown pigmentation), and increased eyelash length, thickness, and number.

Use with caution in patients with a history of intraocular inflammation (e.g., iritis or uveitis).

Use with caution in patients with pseudophakic or aphakic eyes due to the risk of macular edema.

Keep the tip of the dropper sterile and avoid touching the eye or surrounding surfaces to prevent contamination.

Use in Pregnancy and Breastfeeding:

Pregnancy Category C (U.S.): Tafluprost should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

It is unknown whether it is excreted in human breast milk. Caution should be used if administered to a breastfeeding mother.

Storage:

Unopened single-use containers should be stored in the refrigerator (2°C to 8°C / 36°F to 46°F).

Once opened (usually at the level of the individual single-dose container), the drops should be used immediately and any unused portion discarded.

Some formulations are stable at room temperature for a limited time—always follow the manufacturer's storage instructions.

Special Features:

Preservative-Free: Many tafluprost formulations (such as Zioptan and Saflutan) are free from preservatives such as benzalkonium chloride (BAK), reducing the risk of eye surface toxicity and allergic reactions. This makes it a good choice for patients with dry eyes or sensitivity to preservatives.

Drug Interactions:

There are no significant systemic drug interactions known due to the topical ophthalmic use and minimal systemic absorption; however, consult with a healthcare provider or pharmacist if you are using multiple eye medications.

Summary:

Tafluprost is an effective, once-daily medication for managing elevated intraocular pressure in glaucoma and ocular hypertension. Its preservative-free formulation and good tolerability make it a favorable option, particularly for patients with sensitive eyes or those requiring long-term therapy. Like all medications, it should be used under the supervision of an eye care professional and with proper adherence to dosage instructions.

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FAQ

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Q5. What HyperChem will provide after shipment?

For sample orders: 
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2. Packaging photo
3. COA, MSDS, etc
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