High Quality 98% Apigenin CAS 520-36-5 Food Grade Light yellowish Powder Plant Extract

Apigenin More Info

Apigenin is a naturally occurring flavone (4′,5,7-trihydroxyflavone) found in many plants, vegetables, fruits, and herbs. It belongs to the flavone class of polyphenols and is biosynthesized via the phenylpropanoid and flavone synthesis pathways starting from aromatic amino acids like L-phenylalanine or L-tyrosine.

Mechanism of Action

Apigenin exerts multiple biological effects through diverse mechanisms:
Anti-inflammatory: It down-regulates the NF-κB pathway, reducing pro-inflammatory cytokines such as IL-1β and IL-18, and increases anti-inflammatory cytokine IL-10 production. This action helps suppress inflammation in tissues including lungs, colon, and cardiac tissue.
Anticancer: Apigenin modulates cellular processes such as apoptosis, angiogenesis, metastasis, autophagy, cell cycle regulation, and immune responses by activating or inhibiting various signaling pathways and molecules in cancer cells.
Neuroprotective: It promotes neuronal development and plasticity by binding to estrogen receptors, which stimulate neurogenesis and protect neurons. Apigenin also shows anti-amyloidogenic properties that may prevent amyloid plaque formation linked to Alzheimer’s disease.
Enzyme Modulation: Apigenin inhibits cytochrome P450 enzymes (notably CYP3A4), which affects drug metabolism, potentially altering plasma levels of co-administered drugs like imatinib.
NAD+ Modulation: Apigenin inhibits CD38, a NAD+-consuming glycoprotein, thereby increasing NAD+ levels. This mechanism is linked to improved metabolism, aging, sleep regulation, and neuroprotection.
GABAergic Effects: It has agonistic and antagonistic effects on GABA receptors, contributing to its sedative and anxiolytic properties.

Applications

Cancer Therapy: Apigenin shows promise in managing various cancers by targeting tumor cells, especially with nanoformulations that improve its solubility and bioavailability.
Anti-inflammatory Conditions: It is studied for inflammatory diseases such as colitis, cardiac inflammation, and lung inflammation.
Neurodegenerative Diseases: Potential therapeutic agent for Parkinson’s and Alzheimer’s diseases due to neuroprotective and cognition-enhancing effects.
Cardiovascular Health: May lower LDL cholesterol and reduce heart disease risk.
Sleep and Anxiety: Exhibits sedative and anxiolytic effects, improving sleep quality and mood, supported by clinical studies with chamomile extract containing apigenin.
Metabolic Health: Through NAD+ elevation, it may positively affect aging and metabolic pathways.

Routes of Administration

Oral: The most common route, either via dietary intake (fruits, vegetables, chamomile tea) or as concentrated supplements/capsules. Oral bioavailability is about 30%, with peak plasma concentration reached within 0.5 to 2.5 hours and a half-life around 2.5 hours.
Potential for Parenteral: Though not commonly used, modified formulations or injections could be employed to improve bioavailability if needed.

Safety and Side Effects

General Safety: Apigenin is considered non-toxic and safe for consumption in typical dietary amounts and moderate supplementation.
Allergic Reactions: Rare cases of skin rash, itching, swelling, dizziness, and breathing difficulties have been reported; immediate medical attention is advised if these occur.
Drug Interactions: May enhance sedative effects of certain medications, increasing drowsiness; caution is advised when combined with sedatives or other drugs metabolized by CYP enzymes.
Toxicity: High doses from concentrated supplements could potentially lead to toxicity, though this is unlikely with normal dietary intake.
Pregnancy and Breastfeeding: Insufficient research to confirm safety; consultation with healthcare providers is recommended before use.

Pharmacokinetics

Absorption: Apigenin is absorbed systemically after oral administration and undergoes enterohepatic recirculation.
Bioavailability: Approximately 30%, which limits efficacy from dietary sources alone; supplements are needed to reach therapeutic plasma levels.
Metabolism: Primarily metabolized by cytochrome P450 enzymes, especially CYP3A4, which apigenin can inhibit, affecting drug metabolism.
Elimination: The elimination half-life averages about 2.5 hours.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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For non-ready stock, please contact HyperChem sales team to negotiate.

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Q5. What HyperChem will provide after shipment?

For sample orders: 
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Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
Food Ingredients
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Agriculture fertilizer
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HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.