Best Price 99% Dutasteride CAS 164656-23-9

Dutasteride More Info

Dutasteride (CAS 164656-23-9) is a dual 5α-reductase inhibitor developed as a second-generation therapeutic agent for androgen-related conditions. This synthetic 4-azasteroid compound demonstrates potent inhibition of both Type I and Type II 5α-reductase enzymes, distinguishing it from single-enzyme inhibitors like finasteride. Initially approved by the FDA in 2001, dutasteride was designed to provide more comprehensive suppression of dihydrotestosterone (DHT) conversion, particularly in tissues where both enzyme isoforms are present. Its enhanced pharmacokinetic profile allows for once-daily dosing, offering improved patient compliance compared to earlier treatments. The compound's development represented a significant advancement in endocrinology and men's health therapeutics.

Applications and Fields of Use

Clinically, dutasteride is primarily prescribed for the treatment of benign prostatic hyperplasia (BPH) to reduce prostate volume and improve urinary symptoms. It also shows efficacy in androgenetic alopecia (male pattern hair loss) as an off-label application, particularly in cases resistant to first-line therapies. The pharmaceutical industry utilizes dutasteride in combination therapies with α-blockers for enhanced BPH management. Research applications include studies on androgen-dependent conditions and as a reference compound in the development of novel antiandrogenic agents. Ongoing investigations explore its potential in preventing prostate cancer in high-risk populations.

Market and Industry Relevance

The global dutasteride market remains robust, with brand-name and generic formulations generating significant revenue in urology and dermatology sectors. As a key player in the $4+ billion BPH treatment market, dutasteride maintains strong positioning despite patent expirations due to its proven efficacy profile. Emerging markets in Asia and Latin America show increasing demand as awareness of men's health issues grows. The compound's inclusion in various national drug formularies and its availability in fixed-dose combinations contribute to sustained market presence. Specialty pharmacies and compounding facilities also utilize dutasteride for customized dosage forms in hair loss treatments.

Precautions and Considerations

Dutasteride requires careful patient selection due to potential side effects including sexual dysfunction and mood changes. The drug is absolutely contraindicated in women of childbearing potential due to risk of fetal abnormalities. Healthcare providers must monitor for rare but serious adverse effects such as high-grade prostate cancer detection and depression. The compound's long half-life (approximately 5 weeks) necessitates extended discontinuation periods before attempting conception. Proper storage at controlled room temperature (20-25°C) is essential for maintaining stability. Pharmacists should ensure proper handling to prevent exposure in pregnant women, as the drug can be absorbed through skin contact.

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