USP / EP 99% Vitamin B12 68-19-9

Vitamin B12  More Info

Vitamin B12 (CAS 68-19-9), also known as cobalamin, is a water-soluble organometallic compound featuring a cobalt-centered corrin ring structure. First isolated from liver extracts in 1948, this essential nutrient represents the most chemically complex of all vitamins. Commercial production primarily occurs through microbial fermentation using Pseudomonas denitrificans or Propionibacterium species, yielding various forms including cyanocobalamin and methylcobalamin. Its unique biochemical properties enable critical enzymatic reactions in mammalian metabolism, particularly in DNA synthesis and neurological function. The compound's stability varies significantly between forms, with cyanocobalamin being the most shelf-stable pharmaceutical variant.

Applications and Fields of Use

Therapeutic applications focus on treating megaloblastic anemia and neurological disorders resulting from B12 deficiency. Nutraceutical formulations incorporate it for energy metabolism support, particularly in vegan diets lacking natural B12 sources. Clinical diagnostics utilize radioactive B12 isotopes for Schilling tests of absorption capacity. Emerging research explores its potential in neurodegenerative disease management and as a nitric oxide regulator. Industrial applications include animal feed supplementation and fermentation media enrichment. The cosmetic industry employs it in topical formulations for skin regeneration and anti-aging properties, though dermal absorption remains pharmacologically unproven.

Market and Industry Relevance

Global vitamin B12 market size exceeds $350 million annually, with China and India dominating fermentation-based production. Pharmaceutical-grade material commands premium pricing (≥98% purity), while agricultural-grade serves livestock nutrition needs. The vegan nutrition sector drives 25% annual growth in certain markets, with methylcobalamin forms gaining preference. Regulatory classifications vary - while recognized as Generally Recognized As Safe (GRAS) in foods, injectable forms require strict GMP compliance. Price fluctuations occur due to fermentation yield variability and environmental regulations affecting production costs. Emerging nasal spray and sublingual delivery systems are creating new market segments beyond traditional tablets and injections.

Precautions and Considerations

Parenteral administration requires awareness of rare anaphylactic reactions to cobalt or preservatives. Quality verification should include testing for microbial endotoxins in sterile formulations. Light-sensitive forms like hydroxocobalamin require amber glass packaging. The cyanocobalamin form releases minimal cyanide during metabolism, contraindicating use in Leber's optic atrophy. Storage stability ranges from 2-8°C for liquid forms to room temperature for properly packaged solids. Regulatory compliance requires proper labeling of source material (animal-derived vs. microbial) for vegetarian/vegan markets. Occupational exposure limits apply to airborne particulates in manufacturing facilities.

Package Image

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.