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Pharmaceutical Grade Posaconazole of High Purity and Quality CAS No 171228-49-2 for Healthcare Use

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CAS No.:

171228-49-2

Grade:

Pharmaceutical Grade

Content:

99%

Port:

SHANGHAI

Brand:

HyperChem

Packaging:

10g/bag, 50g/bag, 100g/bags or other quantities

Price valid (until):

2025-11-14

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
Seller Information
Inquiry History

Description

Name	Posaconazole
CAS number	171228-49-2
Description	Posaconazole is a second-generation synthetic triazole antifungal agent, developed as a structural analog and therapeutic advancement of itraconazole.
Structural formula
Molecular Formula	C37H42F2N8O4
Molecular Weight	700.78 g/mol
Appearance	White powder
Quality Standard	99%
Storage Condition	Cool dry place( away from the light)
Shelf Life	>2 years if stored properly
Sample package	Aluminium foil bag
Commercial package	Aluminium Tin, Fiber drum
Origin	China

Posaconazole More Info

Posaconazole is a second-generation synthetic triazole antifungal agent, developed as a structural analog and therapeutic advancement of itraconazole. Its molecular design incorporates a extended side chain that enhances both its antifungal spectrum and pharmacokinetic properties compared to earlier azole compounds. The compound functions through selective inhibition of the fungal enzyme lanosterol 14α-demethylase, which is essential for ergosterol synthesis in fungal cell membranes. This inhibition leads to accumulation of toxic methylated sterol precursors and depletion of vital membrane components, resulting in fungal cell death. Developed to address limitations in existing antifungal therapies, posaconazole demonstrates particularly improved activity against zygomycetes and other resistant fungal pathogens while offering more predictable bioavailability.

Uses and Applications

The primary clinical application of posaconazole is in the prophylaxis and treatment of invasive fungal infections in immunocompromised patients. It is specifically indicated for prevention of invasive Aspergillus and Candida infections in high-risk patients undergoing chemotherapy or hematopoietic stem cell transplantation. Therapeutic applications include treatment of oropharyngeal candidiasis, refractory invasive fungal infections, and as salvage therapy for infections resistant to other antifungals. The medication is formulated in multiple delivery systems including oral suspension, delayed-release tablets, and intravenous solution to accommodate different patient populations and clinical scenarios. The development of these varied formulations has significantly improved its bioavailability and clinical utility across diverse healthcare settings.

Application Market

The market for posaconazole operates within the specialized antifungal pharmaceutical sector, characterized by both branded and generic competition following patent expiration. As a critical component in the management of immunocompromised patients, it maintains a strong presence in hospital formularies and transplant centers worldwide. The market distribution includes hospital pharmacies, specialty distributors, and retail pharmacies, with significant utilization in oncology centers and transplant units. Geographic market patterns show concentrated use in regions with advanced medical systems capable of managing immunocompromised patients. Market dynamics are influenced by the growing population of immunocompromised patients, increasing fungal resistance patterns, and the availability of generic alternatives affecting pricing structures.

Important Considerations

Clinical use of posaconazole requires careful management of drug interactions and therapeutic monitoring. The compound is a strong inhibitor of CYP3A4 and UGT enzymes, creating numerous potentially serious interactions with medications including calcineurin inhibitors, sirolimus, and certain antiarrhythmics. Important safety considerations include QT interval prolongation, hepatotoxicity, and electrolyte disturbances necessitating regular monitoring. Administration requirements vary by formulation, with the oral suspension requiring administration with food or nutritional supplements to enhance absorption, while the delayed-release tablet and intravenous formulations have different administration protocols. Storage conditions must adhere to specific requirements for each formulation, particularly regarding temperature control and protection from light for stability maintenance.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

Bank transfer

PayPal

Bitcoin...

Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express
FedEx UPS DHL EMS
Fast: 3-7 days around, high cost, door to door service

By Air
Suitable for more than 50kg
Fast: 3-7 days, hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Fast: 7-45 days, low cost, port to port, professional broker needed

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders:
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

Certificates

Basic Info

Product Name:

Posaconazole

Other Name:

D-threo-Pentitol,2,5-anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-;2,5-Anhydro-1,3,4-trideoxy-2-C-(2,4-difluorophenyl)-4-[[4-[4-[4-[1-[(1S,2S)-1-ethyl-2-hydroxypropyl]-1,5-dihydro-5-oxo-4H-1,2,4-triazol-4-yl]phenyl]-1-piperazinyl]phenoxy]methyl]-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol;Sch 56592;Posaconazole;Noxafil;Posaconazole SP;177571-33-4;2408464-47-9

CAS No.:

171228-49-2

Molecular Formula:

C37H42F2N8O4

InChIKeys:

InChIKey=RAGOYPUPXAKGKH-XAKZXMRKSA-N

Molecular Weight:

700.78

Exact Mass:

700.78

EC Number:

200-659-6

UNII:

6TK1G07BHZ

DSSTox ID:

DTXSID6049066

NCI Thesaurus Code:

C61500

Color/Form:

White solid

ATC Code:

J02AC04|QS02CA91|J - Antiinfectives for systemic use

Categories:

Antibiotics

Characteristics

PSA:

112

XLogP3:

4.6

Appearance:

White solid

Density:

1.36±0.1 g/cm3(Predicted)

Melting Point:

164-165 °C @ Solvent: Acetonitrile

Boiling Point:

850.7±75.0 °C(Predicted)

Flash Point:

9℃

Refractive Index:

1.658

Water Solubility:

H2O: Insoluble

Storage Conditions:

-20°C Freezer

Vapor Pressure:

8.76E-31mmHg at 25°C

Dissociation Constants:

pKa = 2.27 (1,2,4-triazole amine)

Experimental Properties:

Hydroxyl radical reaction rate constant = 2.9X10-11 cu cm/molecule-sec at 25 °C (est)

See More Posaconazole Properties 

Hazard Identification

Classification of the substance or mixture

Reproductive toxicity, Category 2

Specific target organ toxicity â repeated exposure, Category 1

Hazardous to the aquatic environment, short-term (Acute) - Category Acute 1

Hazardous to the aquatic environment, long-term (Chronic) - Category Chronic 1

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H361 Suspected of damaging fertility or the unborn child H372 Causes damage to organs through prolonged or repeated exposure H400 Very toxic to aquatic life H410 Very toxic to aquatic life with long lasting effects
Prevention	P203 Obtain, read and follow all safety instructions before use. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P260 Do not breathe dust/fume/gas/mist/vapours/spray. P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P273 Avoid release to the environment.
Response	P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell. P391 Collect spillage.
Storage	P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More Posaconazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Certifications:
Certification Report by Bureau Veritas

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Posaconazol	50.00 KG	Mar 6, 2026
India	15 Years GMP Factory Supply Posaconazole API	10 G	Nov 14, 2023
Pakistan	Posaconazole Solid Dispersion	5 KG	Mar 20, 2026
Pakistan	POSACONAZOLE	5 KG	Mar 3, 2026

Post an enquiry for this product

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