API High Quality 98% Quercetin

Quercetin More Info

Chemical Profile and Structural Characteristics

Quercetin (CAS 117-39-5) is a flavonol belonging to the polyphenolic flavonoid group, with the chemical name 3,3′,4′,5,7-pentahydroxyflavone. Its molecular structure features a 15-carbon skeleton arranged as two benzene rings (A and B) connected by a heterocyclic pyran ring (C). The compound crystallizes as yellow needles with a molecular weight of 302.24 g/mol and demonstrates limited water solubility but good solubility in alcohols, lipids, and other organic solvents. The specific arrangement of hydroxyl groups at positions 3, 5, 7, 3′, and 4′ is critical for its redox properties and biological activities.

Mechanism of Action and Biological Activities

The compound functions as a potent antioxidant through direct free radical scavenging via electron donation, metal ion chelation at catechol sites, and regeneration of endogenous antioxidants like vitamin E. Quercetin modulates cellular signaling pathways including MAPK, PI3K/Akt, and NF-κB, influencing inflammation, apoptosis, and cell proliferation. Additional mechanisms include inhibition of enzymes such as cyclooxygenase, lipoxygenase, and xanthine oxidase, along with activation of the Nrf2 pathway to enhance cellular defense systems. Its ability to interact with estrogen receptors and affect mitochondrial function further contributes to its diverse biological profile.

Therapeutic Applications and Health Benefits

Research supports quercetin's potential in cardiovascular health through improvement of endothelial function and reduction of oxidative stress in vascular tissues. The compound demonstrates significant anti-inflammatory effects relevant for allergic conditions, arthritis, and inflammatory bowel diseases through modulation of cytokine production and immune cell activity. Neuroprotective applications focus on its ability to cross the blood-brain barrier and mitigate oxidative damage in models of neurodegenerative disorders. Additional benefits include support for metabolic health through AMPK activation, enhancement of exercise performance via mitochondrial biogenesis, and potential antiviral activity against respiratory pathogens.

Formulation Strategies and Bioavailability Enhancement

Advanced delivery systems address quercetin's pharmacokinetic challenges through phospholipid complexes that improve lymphatic absorption, nanoparticle formulations that enhance solubility and tissue distribution, and cyclodextrin inclusions that increase stability and bioavailability. Chemical modifications including glycosylation produce derivatives with improved absorption characteristics through utilization of intestinal transport mechanisms. We provide comprehensive technical data supporting formulation development with compatibility information for common excipients, stability profiles under various conditions, and guidance on manufacturing processes to optimize product performance.

Quality Specifications and Manufacturing Standards

Our quercetin meets stringent quality specifications with HPLC purity ≥95%, comprehensive impurity profiling, and verification of heavy metals, pesticide residues, and microbial limits. The manufacturing process employs validated extraction and purification methodologies with controlled crystallization to ensure consistent particle size and polymorphic form. Analytical characterization includes UV-Vis spectroscopy for identification, HPLC-DAD for purity assessment, and LC-MS for structural confirmation. Stability studies support appropriate storage recommendations and shelf-life determinations for both active ingredient and finished products across various application formats.

FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

Q2. What is the HyperChem payment term?

T/T in advance
LC at sight
DP at sight

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Q3. What is HyperChem shipment policy?

Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
FedEx  UPS  DHL  EMS                               
Fast: 3-7 days around, high cost, door to door service

By Air                                        
Suitable for more than 50kg 
Fast: 3-7 days, hight cost, port to port, professional broker needed 

By Sea
Suitable for more than 500kg      
Fast: 7-45 days, low cost, port to port, professional broker needed 

We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
After shipment is done, an timely email including:

1. Track details (Fedex /TNT/DHL/EMS Track number)
2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.