99% Crizotinib High Purity Pharmacy Grade Anti-Cancer Raw Power CAS 877399-52-5

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Chemical Profile and Structural Characteristics

Crizotinib (CAS 877399-52-5) is a small molecule inhibitor with a molecular weight of 450.34 g/mol, featuring a unique structural framework based on a 2,4-pyrimidinediamine core. The compound incorporates strategic substituents including a fluorinated phenyl ring and a piperidine moiety that collectively contribute to its target specificity and pharmacokinetic profile. It presents as a solid material with defined crystalline properties and demonstrates optimal lipophilicity for both oral bioavailability and tissue penetration. The specific stereochemistry and spatial arrangement of functional groups are critical for its selective interaction with target kinases.

Mechanism of Action and Biological Activity

The compound functions as a potent and selective dual inhibitor of anaplastic lymphoma kinase (ALK) and c-Met/hepatocyte growth factor receptor (HGFR) tyrosine kinases. It competitively binds to the ATP-binding pocket of these kinases, preventing phosphorylation and subsequent activation of downstream signaling pathways including PI3K/AKT, STAT, and RAS/MAPK. This targeted inhibition is particularly effective in tumors driven by ALK rearrangements or c-Met amplifications, resulting in cell cycle arrest, induction of apoptosis, and reduction of tumor cell proliferation and survival. The compound demonstrates nanomolar potency against its primary targets with significant selectivity over other kinases.

Therapeutic Applications and Clinical Utility

Crizotinib is approved for the treatment of ALK-positive and ROS1-positive non-small cell lung cancer, representing a paradigm shift in precision oncology for molecularly defined subsets of lung cancer. Clinical protocols typically initiate therapy at 250 mg administered orally twice daily, with treatment continuation until disease progression or unacceptable toxicity. The compound has demonstrated significant improvement in response rates and progression-free survival in multiple clinical trials, establishing it as a standard of care in these genetically selected patient populations. Additional investigational applications include MET-amplified solid tumors and other malignancies with relevant molecular alterations.

Formulation Strategies and Pharmaceutical Development

We supply crizotinib active pharmaceutical ingredient suitable for the development of immediate-release oral formulations, primarily hard gelatin capsules. The compound demonstrates appropriate stability in solid dosage forms when protected from excessive moisture and light. Formulation approaches focus on ensuring consistent dissolution characteristics and maintaining chemical integrity throughout the product shelf life. Our technical data includes comprehensive compatibility information with common pharmaceutical excipients and guidance on manufacturing processes to achieve robust product performance and quality for this targeted therapeutic agent.

Quality Specifications and Analytical Controls

Our crizotinib meets rigorous pharmacopeial standards with specifications including identification by chromatographic and spectroscopic methods, assay requirement of 98.0-102.0%, and of related substances and degradation products. Critical quality attributes encompass tests for residual solvents, heavy metals, microbial limits, and specific characterization of stereochemical purity. We employ validated stability-indicating HPLC methods for precise quantification and impurity profiling, supported by mass spectrometric techniques for structural confirmation. Storage recommendations specify protection from light and moisture at controlled room temperature to ensure chemical stability throughout the product lifecycle.

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FAQ

Q1. Can I get a free sample?

We can send you a samll free sample, and you only need to pay for the shipping cost.

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Our policy is to strive for the quickest shipment time possible.

For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

Q4. What is HyperChem shipment term?

By Express  
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Suitable for more than 50kg 
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By Sea
Suitable for more than 500kg      
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We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. What HyperChem will provide after shipment?

For sample orders: 
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2. Packaging photo
3. COA, MSDS, etc
4. Dispatch date & Estimated arriving time
5. Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided in scan-copy and original, to help customers complete the customs clearance process.

Company Profile

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
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Cosmetic Ingredients
Food Ingredients
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Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.