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4-Methylimidazole CAS:822-36-6

Name: 4-Methylimidazole CAS:822-36-6
Brand: Orient
SKU: pr2511251291
Price: 5 USD
Availability: InStock

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CAS No.:

822-36-6

Grade:

Industrial Grade

Content:

99%

Port:

shanghai

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-25

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

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Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

4-Methylimidazole Basic information

Product Name:	4-Methylimidazole
Synonyms:	1H-Imidazole, 4-methyl-;1H-Imidazole,4-methyl;4(5)-Methylglyoxaline;4(Or 5)-Methylimidazole;4-Me-i;4-methyl-1(3)H-imidazole;4-methyl-1h-imidazol;NSC 40744
CAS:	822-36-6
MF:	C4H6N2
MW:	82.1
EINECS:	212-497-3
Product Categories:	Building Blocks;Chemical Synthesis;Heterocyclic Building Blocks;Building Blocks;Heterocyclic Building Blocks;Imidazoles;Imidazol&Benzimidazole;Miscellaneous;Imidaxoles;bc0001;822-36-6
Mol File:	822-36-6.mol

4-Methylimidazole Chemical Properties

Melting point	44-47 °C(lit.)
Boiling point	263 °C(lit.)
density	1.02
refractive index	1.5037
Fp	>230 °F
storage temp.	2-8°C
solubility	H2O: soluble, clear, colorless to yellow (50 mg/mL)
form	Powder
pka	pK1:7.55(＋1) (25°C)
color	Reddish-brown to green to brown
Water Solubility	Soluble in water.
BRN	1453
InChIKey	XLSZMDLNRCVEIJ-UHFFFAOYSA-N
LogP	0.230
CAS DataBase Reference	822-36-6(CAS DataBase Reference)
IARC	2B (Vol. 101) 2013
NIST Chemistry Reference	4-Methylimidazole(822-36-6)
EPA Substance Registry System	1H-Imidazole, 4-methyl- (822-36-6)

Safety Information

Hazard Codes	C
Risk Statements	21/22-34-22
Safety Statements	26-36/37/39-45-25
RIDADR	UN 3263 8/PG 3
WGK Germany	2
RTECS	NI7350000
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29339900
Hazardous Substances Data	822-36-6(Hazardous Substances Data)

4-Methylimidazole Usage And Synthesis

Chemical Properties	Slightly yellow chunks. soluble in water and ethanol.
Uses	4-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 4-Methylimidazole is a product which results f rom the interaction of reducing sugars with ammonia. 4-Methylimidazole showed convulsant activity in animals and is listed as a possible carcinogen.
Uses	4-Methylimidazole is used for the curing agent of epoxy resin, the main raw material of medicine cimetidine. It can also be used for synthesis of antibacterial agent.
Preparation	4-Methylimidazole is synthesized by the reaction of glyoxal, acetaldehyde and ammonia. Another method to synthesize the compound is by catalytic dehydrogenation of imidazoline derivatives. 4-Methylimidazole may be synthesized from propanol and formamide, by catalytic cyclization of bisformamidipropane or by photolysis of alkenyltetrazole derived from alkenes by sequential epoxidation, ring opening and dehydration (NTP, 2007).
Definition	ChEBI: 4-methylimidazole is imidazole substituted at position 4 by a methyl group. It has a role as a carcinogenic agent and a reaction intermediate.
General Description	4(5)-Methylimidazole was quantified in coffee by GC-MS method.
Biological Activity	4-Methylimidazole forms complexes with heme-containing enzymes such as cytochrome P450 (CYP) and leads to inhibition of mixed-function oxidase activity. 4-Methylimidazole has been reported to significantly inhibit CYP2E1 activity in rat liver and toluenesulfonylurea hydroxylase (CYP2C9) activity in human and rat microsomes. In addition, it stimulated phosphorylation of rabbit kidney (Na and K)-adenosine triphosphatase and exhibited significant antioxidant activity in a lipid peroxyl radical activity capture assay.
Side effects	4-Methylimidazole is an eye irritant, causes burns, may cause corrosive damage to the upper respiratory tract and lungs if inhaled, and is harmful if ingested. In vivo findings: No histopathological changes were observed in 15-day oral studies in rats and mice. A 14-week oral study showed tremors, ataxia, anaemia, vacuolisation of hepatocytes and testicular degeneration in rats and anaemia, vacuolisation of hepatocytoplasm and renal degeneration in mice. Histopathological liver changes were also observed in a 106-week oral study in rats, causing neurological effects including hyperexcitability, convulsions and seizures in livestock and experimental animals. Reproductive organ toxicity and reduced fertility were observed in male rats. Evidence of carcinogenicity: no carcinogenicity in male rats; ambiguous in female rats; clear evidence in male and female mice; irritating or corrosive to rabbit skin.
Purification Methods	Recrystallise 4-methylimidazole from *benzene or pet ether. It has m 56o after sublimation. The picrate has m 162-163.5o (from EtOH). [Beilstein 23 II 60, 2

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A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer, cryptocurrency, etc.

Q4:What if there are quality issues？

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Certificates

Basic Info

Product Name:

4-Methylimidazole

Other Name:

1H-Imidazole,5-methyl-;Imidazole,4-methyl-;1H-Imidazole,4-methyl-;Imidazole,4(or 5)-methyl-;5-Methyl-1H-imidazole;4-Methylimidazole;4(or 5)-Methylimidazole;4(5)-Methylimidazole;5-Methylimidazole;4-Methyl-1H-imidazole;NSC 40744;1H-4-Methylimidazole;872-33-3;163498-05-3;196413-10-2;88054-16-4;928113-28-4

CAS No.:

822-36-6

Molecular Formula:

C4H6N2

InChIKeys:

InChIKey=XLSZMDLNRCVEIJ-UHFFFAOYSA-N

Molecular Weight:

82.1

Exact Mass:

82.10

BRN:

1453

EC Number:

212-497-3

UNII:

Q64GF9FV4I

NSC Number:

40744

DSSTox ID:

DTXSID9025617

Color/Form:

Crystals

HScode:

29339900

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

28.7

XLogP3:

0.2

Appearance:

Reddish-brown to green to brown Powder

Density:

0.9380 g/cm³ @ Temp: 153.0 °C

Melting Point:

56 °C

Boiling Point:

263 °C

Flash Point:

>230 °F

Refractive Index:

1.5037 (14ºC)

Water Solubility:

soluble in water.H2O: soluble , clear, colorless to yellow (50 mg/mL)

Storage Conditions:

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

Vapor Pressure:

0.007 mm Hg at 25 deg C (est)

Explosive limit:

Explosive limits 1.8-10.7 Vol. %

Henrys Law Constant:

Henry's Law constant = 4.14X10-6 atm-cu m/mol at 25 °C (est)

Dissociation Constants:

pKa = 7.51 (est)

Experimental Properties:

Hydroxyl radical reaction rate constant = 9.41X10-11 cu cm/molec-sec at 25 °C (est)

Autoignition Temperature:

555 °C

See More 4-Methylimidazole Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H315 Causes skin irritation H319 Causes serious eye irritation H336 May cause drowsiness or dizziness
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

See More 4-Methylimidazole Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221
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4-Methylimidazole CAS:822-36-6

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