(S)-(+)-Glycidyl Phthalimide 161596-47-0

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

(S)-(+)-Glycidyl Phthalimide Basic information

Product Name:	(S)-(+)-Glycidyl Phthalimide
Synonyms:	(S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE;(S)-(+)-GLYCIDYL PHTHALIMIDE;(S)-GLYCIDYL PHTHALIMIDE;2-[[(2S)-oxiran-2-yl]methyl]isoindole-1,3-dione;Rivaroxaban Impurity 39;2-((2S)-OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE;(S)-(+)-N-(2,3-Epoxypropyl)phthalimide;(S)-N-Glycidylphthalimide
CAS:	161596-47-0
MF:	C11H9NO3
MW:	203.19
EINECS:	454-720-9
Product Categories:	Intermediate of Rivaroxaban;N-Substituted Maleimides, Succinimides & Phthalimides;N-Substituted Phthalimides;Oxiranes;Simple 3-Membered Ring Compounds;bc0001
Mol File:	161596-47-0.mol

(S)-(+)-Glycidyl Phthalimide Chemical Properties

Melting point	102 °C
Boiling point	347.4±15.0 °C(Predicted)
density	1.446±0.06 g/cm3(Predicted)
vapor pressure	0.001-2.17Pa at 25-90.25℃
refractive index	10 ° (C=2.2, CHCl3)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	-2.24±0.20(Predicted)
form	Solid
color	White
Optical Rotation	Consistent with structure
InChI	InChI=1S/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2/t7-/m0/s1
InChIKey	DUILGEYLVHGSEE-ZETCQYMHSA-N
SMILES	C1(=O)C2=C(C=CC=C2)C(=O)N1C[C@H]1CO1
LogP	1.2 at 40℃

Safety Information

Hazard Codes	Xi
Risk Statements	41
Safety Statements	26-39
WGK Germany	2
HS Code	29252900

(S)-(+)-Glycidyl Phthalimide Usage And Synthesis

Chemical Properties	White powder
Uses	(S)-(+)-Glycidyl Phthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500). It is also a key intermediate of rivaroxaban.
Synthesis	Phthalimide and (S)-1-substituent propylene oxide are used as raw materials, a reaction occurs under the action of a catalyst to generate 2-((S)-3-substituent-2-hydroxypropyl isodihydroindole-1,3-dione, and finally (S)-glycidyl phthalimide is generated by means of a ring-closure reaction.
References	[1] Patent: WO2004/112787, 2004, A1. Location in patent: Page 17-18 [2] Patent: WO2004/113301, 2004, A1. Location in patent: Page 18 [3] Tetrahedron Asymmetry, 1996, vol. 7, # 6, p. 1641 - 1648 [4] Heterocycles, 2006, vol. 67, # 2, p. 561 - 566 [5] Chemical communications (Cambridge, England), 2003, # 4, p. 468 - 469

(S)-(+)-Glycidyl Phthalimide Preparation Products And Raw materials

Raw materials	(S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione-->1H-Isoindol-1-one, 3-hydroxy--->(S)-Oxiranemethanol-->(S)-(+)-Epichlorohydrin-->(R)-(-)-Epichlorohydrin-->Potassium phthalimide-->(R)-(+)-Glycidol-->Triphenylphosphine-->Diethyl azodicarboxylate-->Tetrahydrofuran
Preparation Products	2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione



——  Q&A  ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.