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Curcumin CAS:458-37-7

Name: Curcumin CAS:458-37-7
Brand: Orient
SKU: pr2511271819
Price: 5 USD
Availability: InStock

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CAS No.:

458-37-7

Grade:

Industrial Grade

Content:

99%

Port:

SHANGHAI

Brand:

Orient

Packaging:

25kg/bag,500kg/bag, customized

Price valid (until):

2025-12-27

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Qingdao Orient Chemical Co.,LTD

Company Type:

Trader

Location:

China

Qualification:

Main Products:

pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
Seller Information
Inquiry History

Description

Focusing on innovative research, development, and production in the field of fine chemicals, we prioritize technology, quality, and market orientation. We collaborate with global partners to build a high-tech chemical industry chain and promote sustainable development in the industry.

The company's main products include pharmaceutical intermediates, food additives, essence, spices and plant extracts. The products have passed international certification and are exported to Europe, America, Japan, South Korea and Southeast Asia.

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Curcumin Basic information

Food Additive

Product Name:	Curcumin
Synonyms:	Curcumin, Natural Yellow 3, Diferuloylmethane;5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(e,e)-6-heptadiene-3;5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-6-heptadiene-3;6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(E,E)-1;curcuma;haidr;halad;haldar
CAS:	458-37-7
MF:	C21H20O6
MW:	368.38
EINECS:	207-280-5
Product Categories:	Diferuloylmethane, Natural Yellow 3, C.I. 75300;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;pigment;Colorants;Natural Plant Extract;Aromatics;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals;Miscellaneous Natural Products;Analytical Chemistry;Antioxidant;Biochemistry;Indicator (pH);pH Indicators;chemical reagent;pharmaceutical intermediate;Chalcone;Miscellaneous;bc0001;458-37-7
Mol File:	458-37-7.mol

Curcumin Chemical Properties

Melting point	183 °C
Boiling point	418.73°C (rough estimate)
density	0.93
vapor density	13 (vs air)
refractive index	1.4155-1.4175
Fp	208.9±23.6 °C
storage temp.	2-8°C
solubility	ethanol: 10 mg/mL
pka	8.09(at 25℃)
form	powder
Colour Index	75300
color	orange
Odor	Odorless
PH Range	Yellow (7.8) to red-brown (9.2)
biological source	Curcuma longa (Turmeric)
Water Solubility	Slightly soluble (hot)
λmax	430nm
Merck	14,2673
BRN	2306965
Concentration	1 mCi/ml
Solvent	Ethanol
Specific Activity	5-15 Ci/mmol
Stability:	Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
Major Application	Cosmetics, drug-eluting stents, inhibition of formation of skin-wrinkles, treating alzheimer’s disease, skin diseases, coronary restenosis, diabetes, obesity, leukemia, neurofibromas, cancer, antimicrobial, antiviral, antiinflammatory, antiprostate cancer
InChIKey	VFLDPWHFBUODDF-FCXRPNKRSA-N
LogP	3.290 (est)
CAS DataBase Reference	458-37-7(CAS DataBase Reference)
EPA Substance Registry System	Curcumin (458-37-7)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26
WGK Germany	3
RTECS	MI5230000
Hazard Note	Irritant
TSCA	Yes
HS Code	29145000
Hazardous Substances Data	458-37-7(Hazardous Substances Data)
Toxicity	LD50 Oral-Rat-12.200 mg/kg

Curcumin Usage And Synthesis

Food Additive	Curcumin has been widely used in the food industry as a common natural pigment for a long time. It is mainly used for the dyeing of canned food, sausage products and soy sauce products. The amount of curcumin used is determined by normal production needs. The product form of functional food with curcumin as the main component can be general food or some non-food forms, such as capsules, pills or tablets. For general food form, some yellow pigmented foods can be considered, such as cakes, sweets, beverages, etc. Curcumin is a food additive approved by the Codex Alimentarius Commission of the Food and Agriculture Organization of the United Nations (FAO/WHO-1995). The newly promulgated "Standards for the Use of Food Additives" (GB2760-2011) stipulates that frozen drinks, cocoa products, chocolate and chocolate products and candies, gum-based candies, decorative candies, toppings and sweet sauces, batter, coating powder and frying powder , The maximum usage of curcumin in instant rice and noodle products, flavored syrup, compound seasoning, carbonated drinks and jelly is 0.15, 0.01, 0.7, 0.5, 0.3, 0.5, 0.5, 0.1, 0.01, 0.01 g/kg, respectively, margarine and its similar products, cooked nuts and seeds, fillings for grain products and puffed foods can be used in moderation according to production needs.
Description	Curcumin is the major yellow pigment in turmeric and curry and has antioxidant, anti-inflammatory, and antitumor activities. It inhibits nitric oxide (NO) production (IC₅₀ = 6 μM) and reduces inducible nitric oxide synthase (iNOS) activity in LPS-stimulated RAW 264.7 cells. Curcumin inhibits release of histamine and the inflammatory cytokines TNF-α, IL-1β, IL-6, and IL-8 from HMC-1 mast cells. In vivo, curcumin decreases serum levels of histamine and TNF-α, inhibits histopathological changes of nasal mucosa, and decreases the number of sneezes and nasal rubbing in a mouse model of ovalbumin-induced rhinitis. Curcumin (100 or 200 mg/kg) prevents ovalbumin-induced accumulation of 3-nitrotyrosine (3-NT), a marker of oxidative stress, in mouse heart. Topical administration of curcumin (1-10 μmol) reduces the number of tumors induced by phorbol 12-myristate 13-acetate (TPA; ) in mouse skin. Dietary administration of curcumin reduces the number of tongue neoplasms and preneoplastic lesions induced by 4-nitroquinoline 1-oxide (4-NQO) in rats.
Description	The main source of curcumin is the root of Zingiberaceae Curcuma aromatica, rhizome of Curcuma longa (Jiang Huang), Curcuma zedoaria, and Acorus calamus. Among them, Jiang Huang contains about 3–6% curcumin. The traditional Chinese medicine, Jiang Huang, is the root tuber of perennial herbaceous plant Curcuma longa L. of family Zingiberaceae. It was firstly recorded in the “Tang materia medica” (Xin Xiu Ben Cao). It is pungent, bitter, and warm and enters the liver and spleen meridians. It activates the blood, moves qi, dredges meridians, and alleviates pain. In India and other Asian countries, Jiang Huang has more than 6000?years of application history. In Japan, Jiang Huang has a long history of health care, and the people of Okinawa Island regarded Jiang Huang as a holy tribute to the emperor. Jiang Huang mainly comes from Taiwan, Fujian, Guangdong, Guangxi, Yunnan, and Tibet of China and other regions in East Asia and Southeast Asia. It grows in warm and humid climate and sunny environment with abundant rainfall and fears cold frost, drought, and flood. At present, Chinese Pharmacopoeia only included Jiang Huang and Yu Jin which contains curcumin, while curcumin is not included.
Chemical Properties	Several species of Curcuma exist: C. xanthorrhyza, C. domestica, C. zedoafia, C. caesia and C. amada. Although all these are aromatic plants, C. longa is the one used as a flavor ingredient. The plant is originally from southern Asia and is widespread throughout India, Malaysia, Ceylon and Japan. It is a perennial herb whose rhizome yields (like that of ginger, which it also resembles) climbing stalks with leaves only or with leaves and flowers. Reproduction occurs through the splitting of the rhizome, which is the only part used (dried rhizome as is or after previously boiling in water). Turmeric has a spicy, fresh odor reminiscent of sweet orange and ginger and a slightly pungent, bitter flavor.

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—— Q&A ——

Q1:Do you provide sample?

A: Yes, we can provide free sample, you only need pay the shipping cost.

Q2: What is the lead time?

A: For stock goods, it usually take about 5-7 days by air, 15-30 days by sea,For customized products, the delivery time needs to be confirmed based on the actual situation.

Q3: How can I buy? What is the payment method?

A: You can contract us through Email or you can browse our website:orientchem.cc, we have bank transfer,

A：We attach great importance to after-sales service of our products. If there are any quality issues, please contact us within 30 days of receiving the goods and we will handle returns and exchanges for you.

Certificates

Basic Info

Product Name:

Curcumin

Other Name:

1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(1E,6E)-;Curcumin;1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-,(E,E)-;(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;C.I. 75300;C.I. Natural Yellow 3;Curcuma;Haidr;Halad;Haldar;Halud;Indian Saffron;Kacha Haldi;Merita Earth;Souchet;Terra Merita;Turmeric yellow;Yellow Ginger;Yellow Root;Yo-Kin;(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;Diferuloylmethane;E 100 (dye);E 100;trans,trans-Curcumin;Turmeric (dye);Turmeric;Natural Yellow 3;C Yellow 15;Ukon (dye);Ukon;Curcumin I;Curcumine;San-Ei Curcumine AL;San-Ei Gen Curcumine AL;NSC 32982;(E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;Jianghuangsu;Curcumin W;Colorant E 100;NanoCurc;Theracurmin;Biocurcumax;BR 213;INS 100i;Lipocurc;Natxtra;Vacurin;Cureit;Longvida;Curcumax;Kiriyasu Oil Yellow U;Theracurmin CR 011L;(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione;Curcuma yellow;15845-47-3;33171-04-9;73729-23-4;79257-48-0;91884-86-5;2103286-06-0

CAS No.:

458-37-7

Molecular Formula:

C21H20O6

InChIKeys:

InChIKey=VFLDPWHFBUODDF-FCXRPNKRSA-N

Molecular Weight:

368.38000

Exact Mass:

368.38

EC Number:

617-027-4

HScode:

2932999099

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

96.22000

XLogP3:

3.2

Appearance:

Curcumin appears as orange-yellow needles. (NTP, 1992)

Density:

0.93

Melting Point:

183 °C

Boiling Point:

591.4ºC at 760 mmHg

Flash Point:

208.9ºC

Refractive Index:

1.4155-1.4175

Water Solubility:

H2O: Slightly soluble (hot);Very soluble in ethanol, acetic acid

Storage Conditions:

-20ºC

Vapor Pressure:

6.43E-15mmHg at 25°C

Vapor Density:

13 (vs air)

Toxicity:

LD50 orally in Rabbit: > 5000 mg/kg

See More Curcumin Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20 deg C Keep in a dry place.

See More Curcumin Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

A reliable supplier is like insurance.

We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
Integrity is the foundation, quality is life. We would like to work together with you to build a greener and brighter future.

Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

22 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	Curcumin	50.00 KG	Jun 5, 2025
India	Curcumin	25.00 KG	Jun 6, 2025
Bangladesh	Curcumin	2.5 KG	Apr 22, 2026
India	Curcumine 95% HPLC	25.00 KG	Mar 27, 2026
India	Curcumin 99%	100 G	Mar 26, 2025
United States	curcumin	100 KG	Mar 12, 2025
India	Curcumin	1 TON	Dec 6, 2024
New Zealand	Curcumin	1 KG	Jul 18, 2024
South Africa	Curcumin C3 95% Complex	1.00 KG	Jul 3, 2023
India	Curcumin	25.00 KG	Mar 26, 2026
Austria	Curcumin	4000 KG	Oct 9, 2025
India	Curcumin	1.00 KG	Sep 30, 2025
India	Curcumin	50.00 KG	Jul 15, 2025
Egypt	Curcuma longa	250 KG	Aug 22, 2024
India	Curcumin	1000.00 KG	Oct 9, 2025
United States	Curcumin	10 MT	Apr 12, 2024
Saudi Arabia	Curcumin	100 KG	Mar 28, 2024
China	Curcumin	200 KG	Dec 8, 2023
Brazil	CURCUMA LONGA EXTRATO 98%	50.00 KG	Jul 19, 2023
China	Food Additive Curcumin Plant Extract Curcumin for Pharmaceutical Chemicals CAS 458-37-7	500 KG	Dec 8, 2023

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Curcumin CAS:458-37-7

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