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Pharmaceutical Grade Acetaminophen/Paracetamol CAS:103-90-2

Name: Pharmaceutical Grade Acetaminophen/Paracetamol CAS:103-90-2
Brand: HyperChem
SKU: pr2512181145
Price: 16 USD
Availability: InStock

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Unit Price:

$16-19/KG FOB

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CAS No.:

103-90-2

Grade:

Pharmaceutical Grade

Content:

99.9%

Port:

Hangzhou

Brand:

HyperChem

Packaging:

1kg/bag, 25kg/bag, 50kg/bags or other quantities

Price valid (until):

2027-03-31

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Hangzhou Hyper Chemicals Limited

Company Type:

Trader

Location:

China

Payment Terms:

TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average Lead Time:

10 days

Qualification:

Main Products:

Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

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Product Description
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Inquiry History

Description

Name	Paracetamol
CAS number	103-90-2
Synonym	Acetaminophen Paracetamol DC 90% Paracetamol Powder Acetaminophen BP Acetaminophen EP
Related APIs #	Ibuprofen Naproxen Aspirin Metamizole Diclofenac
Description	Paracetamol (acetaminophen) is one of the most-trusted small-molecule APIs in the world. This white, almost odorless crystalline powder is prized for its reliable analgesic and antipyretic properties, yet it is virtually free of gastric irritation, platelet inhibition or overt sedation. Because it carries no structural alerts for genotoxicity or controlled-substance scheduling, Paracetamol remains the first-line choice for mild-to-moderate pain and fever in every age group from neonates to geriatrics. Usage Typical adult monotherapy doses are 0.5–1.0 g every 4–6 h, not exceeding 4 g per 24 h; children receive 10–15 mg/ kg. The molecule is compatible with most excipients and can be formulated as immediate-release tablets, effervescent tabs, syrups, suspensions, chewables, sachets, effervescent granules, suppositories, IV bags and fixed-dose combinations with mild opioids, decongestants or antihistamines. Because it lacks peripheral anti-inflammatory activity, Paracetamol is ideal for patients with asthma, peptic ulcers, bleeding diatheses or NSAID hypersensitivity, and is the only oral analgesic formally recommended throughout pregnancy and lactation . Mechanism of Action Paracetamol crosses the blood–brain barrier within minutes and inhibits prostaglandin (PG) synthesis inside the hypothalamus and spinal cord. It is a weak, indirect inhibitor of COX-1 and COX-2 in broken-cell assays. A brain-specific splice variant once dubbed “COX-3” is also sensitive to the drug, but genomic studies suggest this interaction is minor. Central serotonergic descending pathways are amplified, while the endogenous metabolite AM404 further blocks neuronal Nav1.7/1.8 sodium channels and stimulates cannabinoid CB1 and TRPV1 receptors, dampening pain signals before they reach higher cortical centers. The net result is rapid, opioid-sparing analgesia and a prompt fall in fever without measurable peripheral anti-inflammatory action. Research Findings Large outcome trials (>200 000 patient-years) show that Paracetamol reduces post-operative opioid consumption by 20–30 % and lowers the incidence of opioid-related nausea and respiratory depression. Population pharmacokinetic models confirm linear kinetics from 2 mg kg⁻¹ to 8 mg kg⁻¹ with a terminal half-life of 2.0–3.5 h in every major ethnic group. IV formulations achieve Cmax within 15 min, making them valuable for acute fever in emergency settings. Meta-analyses in osteoarthritis report pain relief comparable to some NSAIDs but with half the number of adverse events and virtually no hypertension or renal deterioration signals. Hepatotoxicity remains the single clinically relevant risk; toxicologists note that daily doses ≤3 g produce no measurable ALT elevation in healthy adults, while accidental ingestion >10 g requires N-acetylcysteine antidote. Future Directions Medicinal-chemistry programs are exploring bioreversible pro-drugs that exploit the AM404 pathway while capping peak plasma concentrations, aiming to widen the safety margin above 4 g day⁻¹. Nano-crystal and lipid-based formulations that deliver 30 % faster onset are already in Phase II trials, as are effervescent bilayer tablets combining Paracetamol with low-dose caffeine for tension-type headache. On the device front, wearable iontophoretic patches that continuously deliver 1 g over 8 h are being studied for post-surgical ambulatory care. Finally, real-time spectroscopic assays for on-tablet authentication are being integrated to combat falsified medicines—an initiative supported by WHO and major pharmacopoeias. With its well-defined toxicology, global regulatory harmonization and a growing body of mechanistic insight, Paracetamol will remain a cornerstone API for safe, effective pain and fever management for decades to come.
Molecular Formula	C ₈ H ₉ N O ₂
Molecular Weight	151.16 g/mol
Appearance	White or almost white powder
Quality Standard	Enterprise standard; 98%- 102%(ICP-AES)
Shipping Condition	Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition	Dry, dark and at 0-28℃ for short term (days to weeks) or -5-8 ℃ for long term (months to years).
Shelf Life	>2 years if stored properly
Sample package	Double plastic bags inside, fiber drum outside, any quantity available.
Commercial package	Aluminium Tin, Fiber drum
Origin	China

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FAQ

Q1. What is the Hyper chem payment term?
T/T advance
LC at sight
DP at sight
Trade assurance
Money gram

Q2. What is Hyper chem shipment policy?
Our policy is to strive for the quickest shipment time possible, with ready stock sample shipment typically going out the same day that your order was placed. Your satisfaction is very important to us.
For non-ready stock, please contact the Hyper Chem sales team to negotiate.

Q3. What hyper chem will provide after shipment?
For sample orders:
After shipment is done, an timely email including:

Track details (Fedex /TNT/DHL/EMS Track number)

Package photo

COA, MSDS, etc

Dispatch date & Estimated arriving time

Shipping invoice

For commercial orders
A full set of shipment documents as well as package photos can be provided
in scan-copy and original, to help customers complete the customs clearance process.

Q4. What is Hyper Chem shipment term?

By Express
DHL  FedEx  TNT  EMS
Fast:5 days around
High cost, door to door service

By Air
Suitable for more than 50kg
Fast :3-7 days Hight cost, port to port, professional broker needed

By Sea
Suitable for more than 500kg
Slow:7-45 days, Low cost, port to port, professional broker needed
We will always attempt to utilize the quickest and most affordable way for customers to receive orders. And follow -up with customers via email for all shipment details as well as updated track information until it arrives without damage.

Q5. Does hyper chem provide a shipment return policy?
Yes, we have.
Return Policy: At Hyper chem, your satisfaction is guaranteed. If you are dissatisfied for any reason with a product, please send back the unused portion along with your packing slip and a brief note on why you were dissatisfied within 45 days of purchase for a full refund to:

Q6. What is hyper chem After-sales service
•Documents support: COA ,MSDS, MOA ,MS Report,HNMR Report,SDS,DMF
• Customer Support: Shipment clearance support, quality issue support
• Automated Customer Service: Our worldwide customers enjoy immediate 24/7 access to the HYPER CHEM support team from any location, at any time.

About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

Among them, our key client industrial sectors around the global are:

Pharmaceuticals
Nutrition Ingredients/ Dietary supplements
Cosmetic Ingredients
Food Ingredients
Veterinary API
Agriculture fertilizer
Custom Synthesis lab supply

HyperChem provides to its wonderful and honorable clients comprehensive purchasing and distribution services which ensure that we are delivering the right generic, raw, or customized product, make sure that we are delivering it at the right time, ensure that it is delivered in the specified amount, and in the right kind of packaging to clients and customers of all types of industries irrespective of their size of operation.

ECHEMI Editorial Reference

Acetaminophen, also known by its common name paracetamol, is a widely utilized medication that serves as an effective analgesic, which means it alleviates pain, and an antipyretic, which refers to its ability to reduce fever. This compound is characterized by its chemical formula C8H9NO2. It is one of the most popular and frequently used over-the-counter drugs available on the market today, and it comes in a variety of formulations to suit different needs and preferences. These formulations can include tablets, capsules, syrups, and even suppositories, making it accessible and convenient for individuals seeking relief from minor aches and pains or the discomfort of fever.
Acetaminophen differs from the nonsteroidal anti-inflammatory agents described in that it is devoid of anti-inflammatory and antirheumatic properties. It was recently shown that acetaminophen, like aspirin, inhibits cyclooxygenase action in the brain and is even stronger than aspirin. On the other hand, the mechanism of analgesic action of acetaminophen is not fully clear, since it acts poorly on peripheral cyclooxygenase.
Acetaminophen is an analgesic and antipyretic compound. Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms. However, it does inhibit COX-2 by 83% and COX-1 by 56% in human bloodex vivo, albeit at a high 1,000 mg dose, with IC50values of 25.8 and 113.7 μM, respectively. Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury. At toxic doses, the acetaminophen metabolite N-acetyl-4-benzoquinone imine (NAPQI; ) depletes glutathione reserves in the liver, leading to an accumulation of NAPQI and subsequent hepatocyte necrosis. Acetaminophen decreases glutathione levels and reduces glutathione peroxidase activity in mice when administered at a dose of 250 mg/kg and induces ferroptotic cell death in primary mouse hepatocytes, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . Acetaminophen has analgesic and antipyretic properties in animal models.
White Solid
Acetaminophen was first discovered by H. N. Morse in 1878. Although many studies on its use as an analgesic were performed, it wasn’t until 1950 that it was marketed under the name Triagesic. Today, its most common trade names are Tylenol and Panadol, but a large percentage of its sales are as a generic drug. It is the most commonly used medication for pain and fever in both the United States and Europe. It is on the World Health Organization's List of Essential Medicines.

Basic Info

Product Name:

Acetaminophen

Other Name:

PARACETAMOL BP2001;PARACETAMOL POWDER BP;PARACETAMOL BP;ACETAMINOPHENOL POWDER PB/USP;PARACETAMOL DC GRADE;PARACETAMOL BP98;PARACETAMOL USP23,BP98;PARACETAMOL POWDER BP2000

CAS No.:

103-90-2

Molecular Formula:

C8H9NO2

InChIKeys:

RZVAJINKPMORJF-UHFFFAOYSA-N

Molecular Weight:

151.16

Exact Mass:

151.16

BRN:

2208089

EC Number:

203-157-5

TSCA:

TSCA listed

Color/Form:

White

HScode:

29242930

Categories:

Antipyretic Analgesics

Characteristics

PSA:

49.33000

XLogP3:

1.4236

Appearance:

White Solid

Density:

1,293 g/cm3

Melting Point:

168-172 °C(lit.)

Boiling Point:

273.17°C (rough estimate)

Flash Point:

188.4±23.2 °C

Refractive Index:

1.5810 (rough estimate)

Water Solubility:

14 g/L (20 ºC)

Storage Conditions:

Acetaminophen preparations should be stored at a temperature less than 40 deg C, preferably between 15-30 deg C; freezing of the oral solution or suspension should be avoided.

Vapor Pressure:

0.008Pa at 25℃

Vapor Density:

Relative vapour density (air = 1): 5.2

Toxicity:

LD50 in mice (mg/kg): 338 orally (Starmer), 500 i.p. (Dahlin, Nelson)

Flammability characteristics:

Non flammable

Explosive limit:

vol% in air: 15

Odor:

odorless

PH:

5.5-6.5 (H2O, 20℃)(saturated solution)

PKA:

9.86±0.13(Predicted)

Henrys Law Constant:

1.5×107mol/(m3Pa) at 25℃, HSDB (2015)

Air and Water Reactions:

Slightly soluble in water.

Reactivity Profile:

Acetaminophen is sensitive to light. Incompatible with strong oxidizers.

Autoignition Temperature:

540 °C

Critical Temperature & Pressure:

Inert atmosphere,Room Temperature

See More Acetaminophen Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

NO open flames. Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Provision to contain effluent from fire extinguishing. Store in an area without drain or sewer access.Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

See More Acetaminophen Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
Pharmaceuticals,Peptide,Cosmetics,Nutritional Supplements

Location:
Rm. 803, Tower 4, LOFT49 Creative City Pioneer Zone, No.88 Jiru Rd. Gongshu Dist., Hangzhou, 310015 ZJ, China

Payment Terms:
TT against copy of documents,D/P,L/C,D/A,O/A,TT against B/L draft before shipment,100% TT in advance

Average lead Time:
10 days

Total Annual Revenue:
$5 million-$10 million

Total Employees:
11-50

Year of Establishment:
2013

Company Certificates
- Certification Report by Bureau Veritas
About HyperChem

Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to meet the needs of a diverse range of pharmaceutical cosmetics ingredients and nootropic supplements companies worldwide.

Our Competitiveness

One-stop supply

Wide Range Of products including pharmaceutical, Cosmetic Ingredients and nootropic supplements

Among all the pharmaceuticals,

90% of them with GMP certificates,

85% of them with DMF files and

50% of them passed FDA approval,

30% get CEP certificate

20% are new R&D products.

Custom Repackaging Service

We can efficiently repackage your material into sample sizes, custom batch-specific sizes, or semi-bulk package sizes according to your specifications. And ensures the product is packaged in a quality-controlled environment and will maintain its integrity throughout every stage of the process.

Quality Control/Quality Assurance

HyperChem is committed to delivering on its promises of top-quality products with verified quality data.

All materials are vigorously inspected by the factory and/or outsourced analytical laboratories to ensure each and every lot meets or exceeds our reference standards.

Trade assurance service with 100% payment protection, It is best achieved by delivering products and services 100% right the first time, on time, every time.

Professional

Transparent Communication

Fast Reaction,

Professional Suggestion

Beyond Expectation.

We have exclusive partnerships with research and production facilities across the country and we offer varied pharmaceutical services in the most cost-efficient way. The production facilities are GMP, WHO-GMP, EU GMP and US FDA approved and are backed by strong regulatory support such as Dossier, DMF, Tech Pack and relevant Stability studies for regulatory filings.

Inquiry History

79 Inquiries

Country	Product	Purchase Quantity	Date Posted
Pakistan	Paracetamol 103-90-2	1 MT	Oct 5, 2023
Netherlands	Paracetamol Powder CAS 103-90-2 GMP Factory Supply	1 MT	Mar 31, 2026
Bangladesh	Acetaminophen cas 103-90-2 PARACETAMOL POWDER 99% high quality	70 MT	Oct 25, 2023
Sri Lanka	Hot Sale Pharmaceutical Raw Material CAS 103-90-2 Acetaminophen Powder Paracetamol	88 MT	Nov 13, 2023
Philippines	Paracetamol powder China supplier price 99% White Powder cas 103-90-2 Evergreen EGC-Paracetamol	100 G	Nov 9, 2023
Philippines	Paracetamol powder China supplier price 99% White Powder cas 103-90-2 Evergreen EGC-Paracetamol	1 KG	Nov 9, 2023
France	High Purity Acetaminophen Powder Paracetamol at Wholesale Price 99% White Powder 103-90-2 Quanjinci	5 KG	Oct 9, 2023
United Kingdom	acetaminophen	1 KG	Jul 10, 2024
Vietnam	Acetaminophen	1 MT	Apr 16, 2025
India	Paracetamol/Acetaminophen	1.00 KG	Sep 27, 2024
Mexico	Acetaminophen	24 MT	Jan 27, 2026
Pakistan	ACETAMINOPHEN	2 KG	Aug 25, 2026
United Kingdom	4-Acetamidophenol	100 G	Aug 17, 2026
Vietnam	Paracetamol	3 MT	Apr 17, 2026
Bangladesh	Paracetamol	10000 KG	Feb 25, 2026
India	Paracetamol	1.00 KG	Jan 26, 2026
United States	Acetaminophen	1 KG	Dec 15, 2025
India	paracetamol powder ip grade	1.00 KG	Dec 12, 2025
Germany	paracetamol	1 20' Fcl	May 27, 2025
Egypt	N- (4-hydroxyphenyl) Acetamide	2	Mar 10, 2025

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Pharmaceutical Grade Acetaminophen/Paracetamol CAS:103-90-2

Product Description

Seller Information

Inquiry History

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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