99% USP Hydroxyurea White Raw Power With Best Price and Fast Delivery

Hydroxyurea More Info

Hydroxyurea is a synthetic organic compound with a simple yet potent molecular structure, designated by the CAS Registry Number 127-07-1. Its chemical formula is CH₄N₂O₂, representing a hydroxylated derivative of urea. This small, water-soluble molecule is notable for its ability to interfere with DNA synthesis, a property that has made it a cornerstone chemotherapeutic and cytoreductive agent for over half a century. In its pure pharmaceutical form, it appears as a white, crystalline powder.

The primary mechanism of action of hydroxyurea is the inhibition of ribonucleotide reductase, a key enzyme essential for DNA synthesis. By scavenging a tyrosine free radical within the active site of this enzyme, it prevents the conversion of ribonucleotides to their corresponding deoxyribonucleotides. This action starves cells of the necessary building blocks for DNA replication. The effect is most pronounced in the S-phase of the cell cycle, leading to the stalling of DNA synthesis and causing cytotoxic effects preferentially in rapidly proliferating cells, such as cancer cells and certain blood cell precursors.

Hydroxyurea has several established clinical applications. It is a standard therapy for the management of myeloproliferative neoplasms, most notably essential thrombocythemia and polycythemia vera, where it effectively controls elevated blood cell counts and reduces thrombotic risk. It is also a crucial drug in the management of sickle cell disease, where it increases the production of fetal hemoglobin, thereby reducing the frequency of painful vaso-occlusive crises and acute chest syndrome. Additionally, it is used as a radiosensitizer in certain head and neck cancers and in the treatment of resistant chronic myeloid leukemia.

This medication is administered orally in capsule or tablet form. It exhibits excellent oral bioavailability, with peak plasma concentrations occurring within one to two hours after ingestion. It is metabolized minimally and is primarily excreted unchanged by the kidneys. Dosing is highly individualized based on the specific condition, patient tolerance, and blood count response. Regular monitoring of complete blood counts is mandatory during therapy to guide dose adjustments and prevent severe myelosuppression.

The safety profile of hydroxyurea is dominated by its dose-dependent myelosuppressive effects, with bone marrow suppression being its primary dose-limiting toxicity. Common adverse effects include leukopenia, thrombocytopenia, anemia, and macrocytosis. Non-hematological side effects can include gastrointestinal disturbances, skin changes such as hyperpigmentation and ulceration, and, rarely, pulmonary fibrosis or severe hepatotoxicity. While it carries risks of teratogenicity and potential carcinogenicity with long-term use, its benefits in managing life-threatening hematologic conditions generally outweigh these risks when used under appropriate medical supervision with careful monitoring.

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We can send you a samll free sample, and you only need to pay for the shipping cost.

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For ready stock samples, they are usually shipped within 3 working days after payment received.
For non-ready stock, please contact HyperChem sales team to negotiate.

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Suitable for more than 50kg 
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For commercial orders
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Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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