API Vitamin A 325000IU/G,USP/EP Pale yellow powder, no foreign objects visible, noforeign matter and no odor.

Vitamin A More Info

Vitamin A is a generic term for a group of fat-soluble retinoids with similar biological activity, with the CAS Registry Number 68-26-8 specifically referring to all-trans-Retinol, its primary alcohol form. This compound's molecular structure is characterized by a β-ionone ring attached to an isoprenoid side chain ending in a polar functional group, which can be an alcohol, aldehyde, or acid. This structure is essential for its biological functions and its susceptibility to oxidation and isomerization. In its pure form, retinol is a pale yellow crystalline solid or oily substance that is insoluble in water but soluble in fats and organic solvents.

The physiological roles of vitamin A are diverse and critical. Its best-known function is in vision, where 11-cis-retinaldehyde serves as the light-absorbing chromophore in the visual pigments of the retina. Beyond vision, all-trans-retinoic acid acts as a potent hormone, binding to nuclear receptors that regulate the transcription of genes involved in cellular differentiation, embryonic development, immune function, and growth. Retinol itself is also essential for reproduction and the maintenance of epithelial tissues and skin.

Vitamin A is obtained from the diet in two primary forms. Preformed vitamin A (retinol and its esters) is found in animal products such as liver, fish liver oils, dairy products, and eggs. Provitamin A carotenoids, like β-carotene from carrots, sweet potatoes, and leafy greens, can be cleaved in the intestine to yield retinol. The body stores vitamin A primarily in the liver as retinyl esters, releasing it into circulation bound to retinol-binding protein as needed to maintain stable plasma levels.

Clinical applications focus on the prevention and treatment of deficiency and its therapeutic use in certain conditions. Vitamin A supplementation is a cornerstone of global public health for preventing night blindness and xerophthalmia in at-risk populations. It is also used therapeutically in high doses to treat measles in children in developing countries to reduce mortality. Topically and systemically, retinoids like tretinoin and isotretinoin are used to treat severe acne and psoriasis. However, its use in cancer chemoprevention has shown mixed and sometimes adverse results in clinical trials.

The safety profile of vitamin A is defined by a narrow therapeutic window. Deficiency leads to a spectrum of disorders from night blindness to corneal ulceration and increased susceptibility to infections. Conversely, hypervitaminosis A from chronic excessive intake of preformed vitamin A causes toxicity symptoms including liver damage, bone pain, blurred vision, teratogenic effects in pregnancy, and increased intracranial pressure. Provitamin A carotenoids from plant sources do not cause toxicity but can lead to benign carotenodermia (yellowing of the skin). This necessitates careful dosing, especially in vulnerable populations like pregnant women.

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Established in 2013, Hyper Chem has exclusive tie-ups with leading manufacturers, supplying raw materials produced in GMP and ISO 9002 certified facilities, and provides high-quality ingredients and raw materials to cater to the requirements of our diverse range of clients.

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