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5-(4-Methylpiperazin-1-yl)-2-nitroaniline - [M54938]

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Unit Price:

$15-18/G FOB

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CAS No.:

23491-48-7

Grade:

Pharmaceutical Grade

Content:

99%

Port:

Mersin Port

Brand:

OEM

Packaging:

Price valid (until):

2027-02-04

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Company Type:

Distributor

Location:

United States

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Product Description
Seller Information
Inquiry History

Description

Name
5-(4-Methylpiperazin-1-yl)-2-nitroaniline
Alt Name
SKU
M54938
CAS
23491-48-7
Formula
C11H16N4O2
Purity
95+%
SMILES
CN1CCN(CC1)c2ccc(c(N)c2)[N+]([O-])=O

5-(4-Methylpiperazin-1-yl)-2-nitroaniline

Product Name5-(4-Methylpiperazin-1-yl)-2-nitroaniline
CASNo: 23491-48-7
MF: C11H16N4O2
MW236.27
EINECS
MOL File23491-48-7.mol

Chemical Properties

Melting point	152-155°C
Boiling point	444.2±45.0 °C(Predicted)
Density	1.264±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	7.35±0.42(Predicted)
Appearance	Light yellow to yellow Solid
InChI	InChI=1S/C11H16N4O2/c1-13-4-6-14(7-5-13)9-2-3-11(15(16)17)10(12)8-9/h2-3,8H,4-7,12H2,1H3
InChIKey	MWLBMGPQZJDFKZ-UHFFFAOYSA-N
SMILES	C1(N)=CC(N2CCN(C)CC2)=CC=C1[N+]([O-])=O
CAS DataBase Reference	23491-48-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Safety Statements	24/25
HazardClass	IRRITANT
HS Code	29335990

Usage And Synthesis

Description

5-(4-Methylpiperazin-1-yl)-2-nitroaniline (MPNA) is a nitrogen-containing compound that is widely used in scientific research and laboratory experiments. It is a derivative of piperazine, which is a cyclic compound consisting of two piperazine rings joined by a single nitrogen atom. MPNA is a colorless, odorless solid that is soluble in water and organic solvents, making it an ideal compound for a variety of applications.

Chemical Properties

Solid

Uses

5-(4-Methylpiperazin-1-yl)-2-nitroaniline and its derivatives are used as inhibitors of SIRT6 for the treatment of diabetes.

Synthesis

Shop 5-(4-Methylpiperazin-1-yl)-2-nitroaniline - [M54938]-Detailed Image 1

109-01-3

Shop 5-(4-Methylpiperazin-1-yl)-2-nitroaniline - [M54938]-Detailed Image 2

2369-11-1

Shop 5-(4-Methylpiperazin-1-yl)-2-nitroaniline - [M54938]-Detailed Image 3

23491-48-7

5-Fluoro-2-nitroaniline (1 g), N-methylpiperazine (0.752 ml) and triethylamine (TEA, 1.86 ml) were mixed in N-methylpyrrolidone (NMP, 1.5 ml). The reaction mixture was placed in a microwave reactor and the reaction was heated at 100°C for 20 hours. After completion of the reaction, it was cooled to room temperature, diluted with deionized water (50 ml), stirred for 20 min and filtered. The resulting yellow solid was washed with deionized water and subsequently dried under high vacuum to give the target product 5-(4-methylpiperazine)-2-nitroaniline (1.45 g). Analyzed by liquid chromatography-mass spectrometry (LC-MS) (condition B): retention time (t R) = 0.47 min; molecular ion peak [M + H]+: 237.19.

References

[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 2, p. 278 - 292
[2] Journal of Medicinal Chemistry, 2016, vol. 59, # 14, p. 6690 - 6708
[3] Patent: US2004/122237, 2004, A1. Location in patent: Page 247-248
[4] Patent: WO2004/18419, 2004, A2. Location in patent: Page 260
[5] Patent: US2010/81653, 2010, A1. Location in patent: Page/Page column 12

Preparation Products And Raw materials

Raw materials

1-Methylpiperazine 5-Fluoro-2-nitroaniline 5-Chloro-2-nitroaniline N-Methyl-2-pyrrolidone Triethylamine

Preparation Products

Items	Specifications
CAS No	23491-48-7
MF	C11H16N4O2

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Certificates

Basic Info

Product Name:

5-(4-Methylpiperazin-1-yl)-2-nitroaniline

Other Name:

BUTTPARK 17\04-69;BENZENAMINE, 5-(4-METHYL-1-PIPERAZINYL)-2-NITRO-;5-(4-METHYL-PIPERAZIN-1-YL)-2-NITROANILINE;5-(4-METHYLPIPERAZIN-1-YL)-2-NITROPHENYLAMINE;5-(4-METHYLPIPERAZINO)-2-NITROANILINE;5-(4-Methyl-1-piperazinyl)-2-nitroaniline;5-(4-Methylpiperazino)-2-Nitro;1-(3-Amino-4-nitrophenyl)-4-methylpiperazine

CAS No.:

23491-48-7

Molecular Formula:

C11H16N4O2

InChIKeys:

MWLBMGPQZJDFKZ-UHFFFAOYSA-N

Molecular Weight:

236.27

Exact Mass:

236.12700

DSSTox ID:

DTXSID20374997

HScode:

29335990

Categories:

Bulk Drug Intermediates

Characteristics

PSA:

78.3

XLogP3:

1.1

Density:

1.264 g/cm3

Melting Point:

152-155°C

Boiling Point:

444.2°C at 760 mmHg

Flash Point:

222.4ºC

See More 5-(4-Methylpiperazin-1-yl)-2-nitroaniline Properties 

Hazard Identification

Classification of the substance or mixture

Skin irritation, Category 2

Eye irritation, Category 2

Specific target organ toxicity â single exposure, Category 3

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H315 Causes skin irritation H319 Causes serious eye irritation H335 May cause respiratory irritation
Prevention	P264 Wash ... thoroughly after handling. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P302+P352 IF ON SKIN: Wash with plenty of water/... P321 Specific treatment (see ... on this label). P332+P317 If skin irritation occurs: Get medical help. P362+P364 Take off contaminated clothing and wash it before reuse. P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P319 Get medical help if you feel unwell.
Storage	P403+P233 Store in a well-ventilated place. Keep container tightly closed. P405 Store locked up.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 5-(4-Methylpiperazin-1-yl)-2-nitroaniline Safety Data Sheet 

Seller Information

Business Type:
Distributor

Main Products:
Fertilizer,Urea,APIs,Sodium Hypochloride

Location:
W153N8358 Manhattan Dr , WI

Payment Terms:
TT against copy of documents,TT against B/L draft before shipment,100% TT in advance

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
11-50

Year of Establishment:
2025

Inquiry History

2 Inquiries

Country	Product	Purchase Quantity	Date Posted
United States	5-(4-methylpiperazin-1-yl)-2-nitroaniline	1 KG	Feb 6, 2026
United States	5-(4-methylpiperazin-1-yl)-2-nitroaniline.	1 KG	Feb 6, 2026

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5-(4-Methylpiperazin-1-yl)-2-nitroaniline - [M54938]

Product Description

Seller Information

Inquiry History

5-(4-Methylpiperazin-1-yl)-2-nitroaniline

Chemical Properties

Safety Information

Usage And Synthesis

Preparation Products And Raw materials

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

More Choices Find All Products for Sale 

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