Basic Parameter Information
Full Name: Pinealon (CNS & Pineal Gland Targeted Bioregulatory Tripeptide, EDR)
Amino Acid Sequence: H-Glu-Asp-Arg-OH (Single letter abbreviation: EDR, Tripeptide)
Molecular Formula: C₁₅H₂₆N₆O₈
Molecular Weight: 418.43 g/mol
CAS Number: 175175-23-2
Appearance: Sterile lyophilized white powder, packaged in vials (main specifications: 10mg / 20mg)
Purity: ≥99% as tested by HPLC, COA quality inspection report attached for each batch
R&D Background: Pinealon is an ultra-short epigenetic bioregulatory tripeptide developed by Professor Vladimir Khavinson at the Institute of Bioregulation and Gerontology, Saint Petersburg, Russia. It belongs to the classic organ-specific regulatory peptide series. Originally extracted from pineal and cerebral cortex tissue, it is now fully chemically synthesized for laboratory research. With ultra-low molecular weight, it easily crosses the blood-brain barrier, cell membrane and nuclear membrane, specifically regulating gene expression of neurons and pineal gland cells, and is widely used in neurobiology, cognitive aging and brain injury preclinical experiments. Pinealon molecular structure
2. Core Mechanism of Action
Pinealon penetrates into the nucleus of neurons and pinealocytes, directly binds specific regulatory sequences of genomic DNA and histones to remodel chromatin, reactivates antioxidant and neuroprotective genes silenced by aging and oxidative stress:
Decondense compact heterochromatin in nerve cell nuclei, restore transcriptional activity of neuronal survival and antioxidant functional genes;
Upregulate intracellular antioxidant enzymes SOD, catalase and GPx, clear excess reactive oxygen species (ROS) and reduce neuronal oxidative damage;
Delay excessive rapid activation of ERK1/2 stress pathway under hypoxia and toxic stimulation, suppress neuronal apoptosis and autophagy induced by excitotoxicity and ischemia;
Regulate key enzyme genes for melatonin synthesis in pineal gland cells, stabilize circadian rhythm signal transduction;
Improve protein synthesis efficiency of senescent neurons, repair damaged synaptic structure and maintain normal neurotransmitter secretion function;
Inhibit overexpression of pro-apoptotic genes in brain tissue, reduce inflammatory infiltration and nerve cell loss after craniocerebral injury.
3. Core Research Efficacy (For Research Laboratory Use Only)
Broad-Spectrum Neuroprotective Research
Eliminate intracellular free radicals, resist hypoxia, ischemia and excitotoxic brain damage; core reagent for cell & animal models of cerebral ischemia, traumatic brain injury and prenatal neural developmental injury.
Anti-Aging & Cognitive Function Regulation
Reactivate aging-silenced nerve cell functional genes, improve learning and memory ability of aged model organisms; applied to research on age-related cognitive decline, dementia and neurodegenerative lesions.
Pineal Gland & Circadian Rhythm Regulation
Optimize melatonin synthesis pathway of pinealocytes, stabilize sleep-wake cycle and endocrine circadian rhythm, used in insomnia, biorhythm disorder and neuroendocrine balance experiments.
Brain Antioxidation & Anti-Inflammation
Reduce oxidative stress and neuroinflammatory response in central nervous system, auxiliary material for research on chronic brain inflammation and oxidative brain aging.
Neural Developmental Protection
Alleviate neural cell damage caused by high homocysteine, toxic metabolites and prenatal adverse stimulation, supporting embryonic neural development related preclinical research.
Supplied as sterile lyophilized white powder, HPLC purity ≥99%, mainstream vial specifications: 10mg, 20mg. Every batch is equipped with full COA, MSDS and HPLC chromatogram test documents.
As a high-purity brain-targeted ultrashort regulatory tripeptide of the Khavinson peptide system, Pinealon can pass through the blood-brain barrier and directly regulate nuclear gene transcription of nerve cells. It simultaneously exerts powerful antioxidant, anti-apoptotic and pineal gland endocrine regulating effects, effectively alleviates various oxidative and traumatic damage of central nervous system, and delays brain tissue aging.
It serves as essential research material for in-vitro neuron cell culture and animal model experiments covering neuroprotection, cognitive anti-aging, pineal gland circadian regulation, brain injury repair and neurodegenerative disease research.
Note: For laboratory research use only, not approved for human oral consumption or clinical injection treatment.
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