Product Overview

Melanotan II Acetate is a synthetic cyclic heptapeptide analog of the naturally occurring peptide hormone alpha-melanocyte-stimulating hormone (α-MSH) . It is a non-selective agonist of melanocortin receptors (MCRs), specifically exhibiting high affinity for MC1R, MC3R, MC4R, and MC5R .

The compound's cyclic structure provides enhanced metabolic stability and improved blood-brain barrier penetration compared to linear peptide analogs, making it a valuable pharmacological tool for melanocortin system research .

Our Melanotan II Acetate is supplied as a high-purity, lyophilized powder manufactured under strict quality control standards. Each batch undergoes rigorous analytical testing to ensure consistent performance for research applications.

Key Features & Benefits

Technical Specifications

Mechanism of Action (Research Context)

Melanotan II Acetate functions as a potent, non-selective agonist of melanocortin receptors, with the following reported binding affinities (Ki values in COS cells expressing human recombinant receptors)：

Upon receptor binding, Melanotan II activates G-protein coupled signaling pathways leading to increased cAMP production, which in turn triggers downstream biological effects relevant to various research areas including pigmentation biology, metabolic studies, and neuroendocrine research.

Reported Research Applications

Based on peer-reviewed scientific literature, Melanotan II Acetate has been investigated in the following research contexts:

1. Pigmentation & Melanogenesis Research

• MC1R activation studies examining melanin synthesis pathways

• Research on skin pigmentation mechanisms

• Photoprotection studies (DNA damage prevention in UV-exposed skin models)

2. Metabolic & Obesity Research

• MC4R-mediated appetite regulation studies

• Energy expenditure and thermogenesis research (UCP1 protein expression in brown adipose tissue) 

• Food intake and body weight modulation studies in animal models 

3. Neurobiology & Nerve Regeneration

• Peripheral nerve recovery studies (sciatic nerve function after mechanical injury) 

• Neuroprotective effects in cisplatin-induced neuropathy models 

4. Receptor Pharmacology

• Melanocortin receptor binding and signaling studies

• Structure-activity relationship (SAR) investigations

• Development and characterization of receptor-selective analogs