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Podophyllotoxin

2 Inquiries

Unit Price: Get Latest Price
CAS No.:

518-28-5

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

g/kg

Price valid (until):

2026-07-04

Company Type:
Manufactory
Location:
China
Qualification:
Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

  • Product Description

  • Seller Information

  • Inquiry History

  • Description

    Podophyllotoxin (also known as podofilox) is a natural cytotoxic lignan extracted from the roots of Podophyllum species (such as Mayapple) that functions primarily as a powerful microtubule-destabilizing agent, topical antiviral therapy, and the structural precursor for major chemotherapy drugs. Unlike its structural epimer picropodophyllotoxin (which selectively blocks IGF-1R), podophyllotoxin directly targets the cellular division machinery. It binds to tubulin to halt cell mitosis, making it highly effective at destroying rapidly proliferating benign and malignant tissues.

    1. Primary Clinical Function: Topical Antiviral Therapy 
    Podophyllotoxin is approved globally as a topical prescription treatment for skin conditions caused by human papillomavirus (HPV): 
    • Eradicates External Genital Warts: It penetrates deep into infected epithelial cells to halt their replication. This causes the localized necrosis, sloughing, and clearing of external genital and perianal warts (condylomata acuminata).
    • Treats Molluscum Contagiosum: Its potent antimitotic action is also used off-label or in specialized formulations to clear lesions caused by the molluscum contagiosum virus.
    2. Microtubule Destabilization & Mitotic Arrest
    At a molecular level, podophyllotoxin acts as a classic spindle poison: 
    • Binds to the Colchicine Site: It binds reversibly to tubulin dimers at the colchicine-binding domain, completely preventing them from polymerizing into microtubules.
    • Triggers G2/M Phase Arrest: Without functional mitotic spindles, dividing cells cannot organize or separate their chromosomes. This locks the cells in the G2/M phase of the cell cycle.

    Basic Info
    Product Name:

    Podophyllotoxin

    Other Name:

    Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,(5R,5aR,8aR,9R)-;Podophyllotoxin;Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one,5,8,8a,9-tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)-,[5R-(5α,5aβ,8aα,9α)]-;(5R,5aR,8aR,9R)-5,8,8a,9-Tetrahydro-9-hydroxy-5-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one;Condylox;Podofilox;(-)-Podophyllotoxin;NSC 24818;Condyline;11016-28-7

    CAS No.:

    518-28-5

    Molecular Formula:

    C22H22O8

    InChIKeys:

    InChIKey=YJGVMLPVUAXIQN-XVVDYKMHSA-N

    Molecular Weight:

    414.41

    Exact Mass:

    414.41

    EC Number:

    208-250-4

    UNII:

    L36H50F353

    NSC Number:

    759591|24818

    DSSTox ID:

    DTXSID3045645

    NCI Thesaurus Code:

    C2362|C29368

    Color/Form:

    Solvated crystals

    ATC Code:

    D - Dermatologicals

    HScode:

    29189090

    Categories:

    Antineoplastic Agents

    Characteristics
    PSA:

    92.7

    XLogP3:

    2

    Appearance:

    White to off-white Powder

    Density:

    1.4±0.1 g/cm3

    Melting Point:

    183 °C

    Boiling Point:

    597.9°C at 760 mmHg

    Flash Point:

    210.2±23.6 °C

    Refractive Index:

    1.606

    Water Solubility:

    1.14e-01 g/L

    Storage Conditions:

    2-8°C

    Vapor Pressure:

    8.3X10-15 mm Hg at 25 deg C /Estimated/

    Toxicity:

    LD50 in rats (mg/kg): 8.7 i.v.; 15 i.p. (Phillips)

    Specific rotation:

    -110.7 º (c=1, CHCl3)

    Henrys Law Constant:

    Henry's Law constant = 3.8X10-18 atm-cu m/mol at 25 °C /Estimated/

    Collision Cross Section:

    190.1 Ų [M+H-H2O]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]|189.6 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

    Experimental Properties:

    Several polymorphic modifications. After drying up: mp = 183.3-184.0 °C. Specific optical rotation = -132.7 deg @ 20 °C/D (chloroform). Solubility in water at 23 °C = 12- mg/L. Soluble in alcohol, chloroform, acetone, warm benzene, glacial acetic acid.|MW: 414.40. Crystals from acetone. MP = 214 °C. Higher-melting modification from abs ethanol, mp 228 °C. Specific optical rotation = +9.4 deg (c=0.7 in chloroform). Solubility in water at 25 °C approx 100 mg/L. Fairly soluble in chloroform, hot ethanol, acetic acid, acetone, dilute caustic; less soluble in benzene ether, carbon tetrachloride, propylene glycol. /Picropodophyllin/|Hydroxyl radical reaction rate constant = 2.2X10-10 cu cm/molecule-sec at 25 °C /Estimated/

    Hazard Identification

    Classification of the substance or mixture

    Acute toxicity - Category 3, Oral

    Acute toxicity - Category 2, Dermal

    Skin irritation, Category 2

    Eye irritation, Category 2

    Specific target organ toxicity – single exposure, Category 3

    GHS label elements, including precautionary statements

    Pictogram(s)
    Signal word

    Danger

    Hazard statement(s)

    H301 Toxic if swallowed

    H310 Fatal in contact with skin

    H315 Causes skin irritation

    H319 Causes serious eye irritation

    H335 May cause respiratory irritation

    Precautionary statement(s)
    Prevention

    P264 Wash ... thoroughly after handling.

    P270 Do not eat, drink or smoke when using this product.

    P262 Do not get in eyes, on skin, or on clothing.

    P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

    P261 Avoid breathing dust/fume/gas/mist/vapours/spray.

    P271 Use only outdoors or in a well-ventilated area.

    Response

    P301+P316 IF SWALLOWED: Get emergency medical help immediately.

    P321 Specific treatment (see ... on this label).

    P330 Rinse mouth.

    P302+P352 IF ON SKIN: Wash with plenty of water/...

    P316 Get emergency medical help immediately.

    P361+P364 Take off immediately all contaminated clothing and wash it before reuse.

    P332+P317 If skin irritation occurs: Get medical help.

    P362+P364 Take off contaminated clothing and wash it before reuse.

    P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.

    P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.

    P319 Get medical help if you feel unwell.

    Storage

    P405 Store locked up.

    P403+P233 Store in a well-ventilated place. Keep container tightly closed.

    Disposal

    P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

    Other hazards which do not result in classification

    no data available

    Handling and Storage

    Precautions for safe handling

    Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

    Conditions for safe storage, including any incompatibilities

    Podofilox topical gel and topical solution should be stored at 15-30 deg C. These preparations should not be exposed to excessive heat; freezing should be avoided. ...

  • Seller Information
    Business Type:

    Manufactory

    Main Products:

    Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

    Location:

    Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

    Total Annual Revenue:

    $2.5 million-$5 million

    Total Employees:

    51-100

    Year of Establishment:

    2019

  • Inquiry History
    2 Inquiries
    Country Product Purchase Quantity Date Posted
    India

    Podophyllotoxin

    13 KG Oct 27, 2025
    China

    鬼臼毒素

    1200 KG Feb 29, 2024
    Post an enquiry for this product
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