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Prostaglandin B2

Name: Prostaglandin B2
Brand: Cuicheng Bio
SKU: pr2606081182
Price: 180000 USD
Availability: InStock

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CAS No.:

13367-85-6

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

1mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Product Description
Seller Information

Description

Prostaglandin B2 (commonly abbreviated as PGB2; CAS 13367-85-6) functions primarily as a potent vasoactive modulator, a co-stimulatory signal in T-cell immune responses, and a specialized reference standard in biochemical research.

Chemically, PGB2 is an unsaturated, 20-carbon cyclopentenone eicosanoid. While it can occur as a natural human metabolite, it is most recognized in the laboratory as a non-enzymatic dehydration product formed when Prostaglandin E2 (PGE2) or PGA2 is exposed to strong basic conditions.

Core Functions and Research Applications

Vascular Tone and Hemodynamic Regulation: PGB2 exerts highly complex, dose-dependent actions on the circulatory system. At low doses, it can trigger peripheral vasodilation. However, at higher physiological concentrations, it functions as an incredibly powerful vasoconstrictor—particularly within pulmonary vascular beds. It binds as a weak agonist to thromboxane-prostanoid (TP) receptors, inducing pulmonary hypertension and increasing smooth muscle tone by disrupting the intracellular sequestration of calcium ions (essentially blocking the relaxation phase of the muscle).
Co-Stimulatory Immune Signal (T-Cell Activation): Unlike its precursor PGE2, which typically behaves as an immunosuppressive agent, PGB2 acts as an ancillary or co-stimulatory lipid mediator in T-lymphocyte networks. In vitro data reveals that exogenous PGB2 synergizes with T-cell receptor (TCR) binding signals. This cascade actively upregulates Interleukin-2 (IL-2) production, drives IL-2Rα expression, promotes nuclear factor-kappa B (NF-κB) translocation, and accelerates the proliferation of peripheral blood lymphocytes.
Inhibition of Dendritic-T Cell Proliferation: In the context of cellular development, PGB2 is identified as a major bioactive constituent secreted by cord blood mesenchymal stem cells, where it functions to suppress dendritic cell-mediated T-cell proliferation, serving as a key molecular subject in stem cell immunotolerance studies.
Lipidomics Reference Standard: Because it is an important catabolic degradation endpoint of PGE2, high-purity PGB2 is essential in analytical chemistry. Laboratories utilize it as a standard baseline in High-Resolution Multiple-Reaction Monitoring Mass Spectrometry (MRM-MS) to map targeted eicosanoid profiles, measure oxidative stress indicators, and study cyclooxygenase (COX) enzyme degradation pathways

Basic Info

Product Name:

PGB2

Other Name:

Prosta-5,8(12),13-trien-1-oic acid,15-hydroxy-9-oxo-,(5Z,13E,15S)-;5-Heptenoic acid,7-[2-(3-hydroxy-1-octenyl)-5-oxo-1-cyclopenten-1-yl]-,stereoisomer;(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid;Prostaglandin B2;PGB2;15-Hydroxy-9-oxoprosta-5,8(12),13-trienoic acid;15α-Hydroxy-9-ketoprosta-5,8(12),13-trienoic acid;28548-75-6

CAS No.:

13367-85-6

Molecular Formula:

C20H30O4

InChIKeys:

InChIKey=PRFXRIUZNKLRHM-HKVRTXJWSA-N

Molecular Weight:

334.45

Exact Mass:

334.45

EC Number:

234-237-8

Categories:

Antibiotics

Characteristics

PSA:

74.6

XLogP3:

3.24

Appearance:

solution

Density:

1.118±0.06 g/cm3(Predicted)

Boiling Point:

537.0±50.0 °C(Predicted)

Flash Point:

-9 °C

Refractive Index:

1.564

Water Solubility:

ethanol: ~100 mg/mL

Storage Conditions:

−20°C

See More PGB2 Properties 

Hazard Identification

Classification of the substance or mixture

Acute toxicity - Category 4, Oral

Acute toxicity - Category 4, Dermal

Acute toxicity - Category 4, Inhalation

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Warning
Hazard statement(s)	H302 Harmful if swallowed H312 Harmful in contact with skin H332 Harmful if inhaled
Prevention	P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area.
Response	P301+P317 IF SWALLOWED: Get medical help. P330 Rinse mouth. P302+P352 IF ON SKIN: Wash with plenty of water/... P317 Get medical help. P321 Specific treatment (see ... on this label). P362+P364 Take off contaminated clothing and wash it before reuse. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing.
Storage	none
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More PGB2 Safety Data Sheet 

Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Prostaglandin B2

Product Description

Seller Information

Classification of the substance or mixture

GHS label elements, including precautionary statements

Other hazards which do not result in classification

Precautions for safe handling

Conditions for safe storage, including any incompatibilities

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