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Reticulol

Name: Reticulol
Brand: Cuicheng Bio
SKU: pr2606081188
Price: 250000 USD
Availability: InStock

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CAS No.:

26246-41-3

Grade:

Industrial Grade

Content:

98%

Port:

guangzhou

Brand:

Cuicheng Bio

Packaging:

1mg

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Description
Reticulol (also known as 6,8-dihydroxy-7-methoxy-3-methylisocoumarin; CAS 26246-41-3) functions primarily as a potent enzyme inhibitor, an antitumor screening compound, and a metabolic reference standard in biochemical and pharmacological research.

It is a natural isocoumarin derivative originally isolated as a secondary metabolite from fermentation broths of Streptomyces species (such as Streptomyces mobilis).

Core Functions and Research Applications

Cyclic Nucleotide Phosphodiesterase (PDE) Inhibition: In cell-signaling studies, reticulol functions as an active inhibitor of cyclic adenosine 3',5'-monophosphate (cAMP) phosphodiesterase. By blocking PDE (IC₅₀ = 41 μM), it prevents the degradation of cAMP, thereby modulating downstream protein kinase A (PKA) pathways and intracellular signaling.

DNA Topoisomerase I Inhibition: It serves as a specialized chemical tool to study DNA replication and topology. Reticulol possesses structural traits that inhibit Topoisomerase I (Topo I), an enzyme critical for unwinding DNA during transcription and replication. This mechanism leads to DNA strand breaks and halts the cellular division cycle.

Antitumor and Cytotoxic Profiling: Because of its dual action in elevating cAMP and blocking Topo I, it is categorized as a promising bio-prospecting molecule for anticancer drug discovery. Researchers screen its performance in tumor cell lines to map growth-inhibition thresholds and evaluate how isocoumarin cores induce apoptosis.

Natural Antibiotic and Antimicrobial Marker: As a microbial metabolic product, high-purity forms (≥ 98%) function as standard baselines to explore natural defense systems against pathogenic fungi and bacteria. It helps analytical laboratories identify and map the chemical ecology of Streptomyces strains during antibiotic synthesis scaling.
Basic Info

Product Name:
Reticulol

CAS No.:
26246-41-3

Categories:
Organic Reagents
Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Reticulol

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