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Ramentaceone

Name: Ramentaceone
Brand: Cuicheng Bio
SKU: pr2606081191
Price: 40000 USD
Availability: InStock

Unit Price:

$40000-45000/G FOB

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CAS No.:

14787-38-3

Grade:

Industrial Grade

Content:

98%

Port:

guingzhou

Brand:

Cuicheng Bio

Packaging:

Price valid (until):

2026-07-08

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Cuicheng Biomedical Technology

Company Type:

Manufactory

Location:

China

Qualification:

Main Products:

Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

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Description
Ramentaceone (commonly known as 7-methyljuglone; CAS 14787-38-3) functions primarily as a potent cytotoxic agent, an oncology pathway inhibitor, and a natural plant-defense molecule in biochemistry and pharmacological research.

It is a naturally occurring hydroxy-1,4-naphthoquinone structurally isolated from insectivorous plants in the Sundew (Droseraceae) family (such as Drosera aliciae) as well as certain roots like Euclea natalensis.

Core Functions and Research Applications

Oncology Research and Apoptosis Induction: Ramentaceone is highly researched for its profound anti-proliferative activity against diverse human cancer models, including human leukemia (HL-60), prostate cancer (LNCaP), and HER2-overexpressing breast cancer cells. It acts through two main pathways:

PI3K/Akt Signaling Inhibition: It directly inhibits phosphoinositide 3-kinase (PI3K) activity and prevents the phosphorylation of Akt. This shuts down a primary cell survival network that tumors use to resist radiation and chemotherapy.

ROS-Mediated Mitochondrial Apoptosis: It triggers the intracellular generation of Reactive Oxygen Species (ROS). This collapses the mitochondrial membrane potential, downregulates anti-apoptotic proteins (Bcl-2), upregulates pro-apoptotic factors (Bax, Bak), and activates caspase-3 to command programmed cell death.

Natural Antimicrobial and Antifungal Defender: In ethnopharmacology, plants containing ramentaceone are utilized for their native therapeutic mechanisms. The molecule functions as a strong antibacterial and antifungal agent, protecting plants against environmental pathogens and serving as a blueprint for anti-infective drug development.

Antitubercular and Antiviral Target Screening: Beyond standard microbes, ramentaceone is used in specialized bioassays to screen for inhibitors against respiratory pathogens and specific viruses, validating why certain Drosera extracts were used historically as traditional antitussive remedies.
Basic Info

Product Name:
Ramentaceone

Other Name:
1,4-Naphthalenedione,5-hydroxy-7-methyl-;1,4-Naphthoquinone,5-hydroxy-7-methyl-;Ramentaceone;5-Hydroxy-7-methyl-1,4-naphthalenedione;7-Methyljuglone;5-Hydroxy-7-methyl-1,4-naphthoquinone;7-Methyl-5-hydroxy-1,4-naphthoquinone;NSC 208733;NSC 624625

CAS No.:
14787-38-3

Molecular Formula:
C11H8O3

InChIKeys:
InChIKey=OZUSCVSONBBWOR-UHFFFAOYSA-N

Molecular Weight:
188.18 g/mol

Exact Mass:
188.18

NSC Number:
624625|208733

DSSTox ID:
DTXSID80163824

Categories:
Bulk Drug Intermediates

Characteristics

PSA:
54.4 Å²

Density:
1.44 g/cm³

Melting Point:
125.5-126.5 °C

See More Ramentaceone Properties 
Seller Information

Business Type:
Manufactory

Main Products:
Ginsenoside Rb1,Ginsenoside Rg1,Ginsenoside Re,Ginsenoside CK,Ginsenoside Rg2,Ginsenoside Rg5

Location:
Chuangzhi valley,Chuangzhi Industrial Park ,Hanzhong Economic and Technological Dvelopment Zone,Hanzhong City, Shaanxi Province

Total Annual Revenue:
$2.5 million-$5 million

Total Employees:
51-100

Year of Establishment:
2019
Country Product Purchase Quantity Date Posted

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Ramentaceone

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