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2,2,2-Trifluoroethanol75-89-8

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Unit Price:

$33-34/MT FOB

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CAS No.:

75-89-8

Grade:

Industrial Grade

Content:

99.5%

Port:

上海

Brand:

OORENT

Packaging:

Vial/Bottle/Bag/Carton

Price valid (until):

2026-07-17

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Qingdao Orient Chemical Co.,LTD

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China

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pharmaceutical intermediates,peptides,electronic chemicals

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Product Description
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Description

Product Detail

2,2,2-Trifluoroethanol Basic information

Description Chemical properties Uses Preparation method Hazards & Safety Information

Product Name:	2,2,2-Trifluoroethanol
Synonyms:	Trifluoro Ethanol(L);2,2,2-Trifluoroethanol,Trifluoroethyl alcohol;2,2,2-Trifluoroethanol, reagent grade;2,2,2-Trifluoroethan;2,2,2-Trifluoroethan-1-ol 99%;2-Hydroxy-1,1,1-trifluoroethane, (Trifluoromethyl)methanol;2,2,2-TRIFLUOROETHANOL-D3, HIGH ENRICHMENT;1,2,2-trifluoroethan-1-ol
CAS:	75-89-8
MF:	C2H3F3O
MW:	100.04
EINECS:	200-913-6
Product Categories:	organofluorine compounds;Organics;API intermediates;Other Reagents;Fluorinated Building Blocks;Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds;Synthetic Organic Chemistry;Chemistry;3;1;bc0001;R00001
Mol File:	75-89-8.mol

2,2,2-Trifluoroethanol Chemical Properties

Melting point	−44 °C(lit.)
Boiling point	77-80 °C(lit.)
density	1.391 g/mL at 20 °C
vapor density	3.5 (vs air)
vapor pressure	70 mm Hg ( 25 °C)
refractive index	n20/D 1.3(lit.)
Fp	85 °F
storage temp.	Store below +30°C.
solubility	soluble in Chloroform, Methanol
pka	12.4(at 25℃)
form	Liquid
color	Clear colorless
Specific Gravity	1.373
Odor	Alcoholic odour
PH	7
PH Range	5-7 (10% aq soln)
biological source	goat
explosive limit	8.4-28.8%(V)
Water Solubility	Miscible with water, ethers, ketones, alcohols and chloroform.
λmax	λ: 260 nm Amax: ≤0.03 λ: 280 nm Amax: ≤0.02
Merck	14,9682
BRN	1733203
Henry's Law Constant	4.7×10^-1 mol/(m³Pa) at 25℃, Burkholder et al. (2019)
Dielectric constant	8.5500000000000007
Stability:	Stable. Flammable - note wide explosion limits. Moisture sensitive. Incompatible with strong oxidizing agents, strong acids, sodium, potassium.
Major Application	sample preparation
InChI	1S/C2H3F3O/c3-2(4,5)1-6/h6H,1H2
InChIKey	RHQDFWAXVIIEBN-UHFFFAOYSA-N
SMILES	OCC(F)(F)F
CAS DataBase Reference	75-89-8(CAS DataBase Reference)
NIST Chemistry Reference	Ethanol, 2,2,2-trifluoro-(75-89-8)
EPA Substance Registry System	2,2,2-Trifluoroethanol (75-89-8)

Safety Information

Hazard Codes	Xn,T,F
Risk Statements	10-20/21/22-37/38-41-62-38-36/37/38
Safety Statements	26-36-39-45-36/37/39-16
RIDADR	UN 1986 3/PG 3
WGK Germany	1
RTECS	KM5250000
Autoignition Temperature	~896 °F
Hazard Note	Flammable/Toxic
TSCA	TSCA listed
HazardClass	3
PackingGroup	III
HS Code	29055910
Storage Class	3 - Flammable liquids
Hazard Classifications	Acute Tox. 3 Inhalation Acute Tox. 3 Oral Eye Dam. 1 Flam. Liq. 3 Repr. 1B STOT RE 2 Inhalation
Toxicity	LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rat 1680 mg/kg

MSDS Information

Provider	Language
2,2,2-Trifluoroethanol	English
ACROS	English
SigmaAldrich	English
ALFA	English

2,2,2-Trifluoroethanol Usage And Synthesis

Description	2,2,2-trifluoroethanol or trifluoroethanol is called TFEA or TEF, it is important intermediate of the fluorine-containing aliphatic, it is colorless, it is miscible liquids with water, it has similar odor with ethanol. Due to the strong electron-withdrawing effect of trifluoromethyl, acid of trifluoromethyl is stronger than ethanol, it can generate hydrogen-bonded stable complex (such as: tetrahydrofuran, pyridine) with heterocyclic compound. Due to this unique physical and chemical properties and special molecular structure, it has different performance with other alcohols, it can participate in a variety of organic reactions, it can be oxidized to acetaldehyde trifluoromethyl or trifluoroacetic acid, it can also provide trifluoromethyl, it can participate in the Still-Gennari improvements of Horner-Wadsworth-Emmons reaction. It has wide range of uses in medicine, pesticides, dyes, energy, and other aspects of organic synthesis. The main use of trifluoroethanol is as anesthetic, at the earliest, fluorine acetylene ether which synthesized by trifluoroethanol and acetylene takes place of bigger side effects of bromine-fluoro alkanes as anesthetic, and then trichloroethanol is used as raw material to develop non-flammable, low toxicity isoflurane alkanes and high performance of the new anesthetic of chlorofluoroalkane. Trifluoroethanol can be introduced into drug structure as trifluoromethyl of functional group, it can generate significant physiological activity, increase fat-soluble of molecules, improve efficacy or reduce side effects of the organism, its synthetic drugs have central nervous system stimulants fluticasone Seoul, substituted pyridines stomach cytoplasmic proton pump inhibitor Lansoprazole and Pariprazole, antiarrhythmic drugs flecainide with amines and analgesic drugs benzodiazepines and dysuria treatment KMD-3212 and so on.
Chemical properties	Boiling point is 73.6℃, melting point is-43.5℃, refractive index is 1.2940, density (25 ℃) is 1.383g/cm3, enthalpy of evaporation is 37.8kJ/mol.
Uses	(1) It can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, synthetic narcotics fluoride ether (Fluroxene), isoflurane (Isoflurane) and to chlorine halothane (Desflurane), central nervous system stimulants fluticasone Seoul (Flowotyl), proton pump inhibitor lansoprazole (Lansoprazol, pp inhibitors), anti-arrhythmic drugs flecainide with amine (Flecamide), analgesics, benzodiazepines (Quazepam), difficulty urinating therapeutic drug KMD-3213, herbicide trifluoromethyl thiomethyl (Triflusulfuronmethyl). (2) It can be used for chemical reagents. (3) It can be used as solvent, it can be used as import agent of trifluoroethyl and trifluoroacetic ethoxycarbonyl agent, it can be also used as pharmaceutical, pesticide intermediates. (4) It can be used as solvent, it is also used as medicine, pesticide intermediates.
Preparation method	Since 1933 Swarts used trifluoroacetic anhydride as raw material, catalytic reduction method was used to get trichloroethanol, we have developed a series of synthetic methods. According to the type, the reaction can be divided into three kinds: oxidation, reduction and hydrolysis. According to raw material, it can be divided trifluoroacetic acid method, trifluoroacetyl chloride method, trifluoroacetic anhydride method, trifluoroacetate law, trifluoroacetic acetaldehyde, polyvinylidene fluoride method, trifluoroethane (HFC-143a) method and trifluoro chloroethane (HCFC-133a) method.
Hazards & Safety Information	Category: Flammable liquid Toxicity grading: highly toxic Acute oral toxicity-rat LD50: 240 mg/kg; Oral-Mouse LD50: 366 mg/kg Irritation data: Skin-Rabbit 0.75 mg/24 hours and severe; Eyes-rabbit 20 mg/24 hr mild Flammability hazard characteristics: When meets fire, heat, oxidants, it is flammable; it can burn and generate toxic fluoride fumes. Storage characteristics: Treasury ventilation low-temperature drying; it should be stored separately with oxidants. Extinguishing agent: Dry powder, dry sand, carbon dioxide, foam, 1211 fire extinguishing agent.
Chemical Properties	Colorless liquid
Uses	In synthesis of medical anaesthetics, pharmaceuticals, and agrochemicals; in polymerizations. Protein denaturant; stabilizes peptide structures. Cleaning solvent; eluent in HPLC separations; working fluid in Rankine heat cycle systems. Environmentally friendly alternative to CFCs.
Uses	Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.
Uses	2,2,2-Trifluoroethanol (Trifluoroethyl alcohol, TFE) is used to study the conformational states of proteins and the folding refolding processes of proteins.
Definition	ChEBI: 2,2,2-trifluoroethanol is a fluoroalcohol. It is functionally related to an ethanol.
Safety Profile	Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation and skin contact. Experimental reproductive effects. A severe skin and eye irritant. When heated to decomposition it emits toxic fumes of F-.
Purification Methods	Dry it with CaSO4 and a little NaHCO3 (to remove traces of acid) and distil it. Highly TOXIC vapour. [Beilstein 1 IV 1370.]

2,2,2-Trifluoroethanol Preparation Products And Raw materials

Raw materials

2,2,2-Trifluorodiazoethane-->Benzene, [(2,2,2-trifluoroethoxy)methyl]--->4-(prop-1-en-2-yl)phenyl acetate

Preparation Products

2-Chloromethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride-->6-(2,2,2-TRIFLUOROETHOXY)NICOTINIC ACID-->2-(2,2,2-TRIFLUOROETHOXY)PYRIDINE-3-CARBOXYLIC ACID-->TRIS(2,2,2-TRIFLUOROETHYL)PHOSPHATE-->TRIFLUOROACETALDEHYDE HYDRATE-->3,3,3-Trifluoropropionic acid-->Isoflurane-->1,1,1,2-Tetrafluoroethane-->2-CHLORO-1,1,1-TRIFLUOROETHANE-->pent-1-en-3-yne-->1,3,2-Dioxaphospholane, 2-(2,2,2-trifluoroethoxy)-, 2-oxide-->2-Hydroxy-1,3,2-dioxaphospholane 2-oxide-->2,6-BIS(2,2,2-TRIFLUOROETHOXY)BENZONITRILE-->2,2,2-TRIFLUOROETHYL CHLOROFORMATE-->1,1,2,3,3,3-HEXAFLUOROPROPYL 2,2,2-TRIFLUOROETHYL ETHER-->Potassium trifluoroacetate

Shop 3-Chloro-1-propene107-05-1-Detailed Image 2

Basic Info

Product Name:

2,2,2-Trifluoroethanol

Other Name:

Ethanol,2,2,2-trifluoro-;2,2,2-Trifluoroethanol;β,β,β-Trifluoroethyl alcohol;2,2,2-Trifluoroethyl alcohol;TFE;NSC 451;2,2,2-Trifluoroethan-1-ol

CAS No.:

75-89-8

Molecular Formula:

C2H3F3O

InChIKeys:

InChIKey=RHQDFWAXVIIEBN-UHFFFAOYSA-N

Molecular Weight:

100.04000

Exact Mass:

100.04

EC Number:

200-913-6

UNII:

8T8I76KYF1

NSC Number:

451

DSSTox ID:

DTXSID0021751

HScode:

2905590090

Categories:

Organic Fluorine Compound

Characteristics

PSA:

20.23000

XLogP3:

0.54100

Appearance:

Liquid

Density:

1.4106 g/cm³ @ Temp: 0 °C

Melting Point:

-43.5 °C

Boiling Point:

74 °C

Flash Point:

29ºC

Refractive Index:

1.2907

Water Solubility:

Miscible with water, ethers, ketones, alcohols and chloroform.

Storage Conditions:

Store at RT.

Vapor Pressure:

70 mm Hg ( 25 °C)

Vapor Density:

3.5 (vs air)

Toxicity:

LD50 orally in Rabbit: 240 mg/kg LD50 dermal Rat 1680 mg/kg

OH:

9.55e-14 cm3/molecule*sec

Henrys Law Constant:

1.73e-05 atm-m3/mole

See More 2,2,2-Trifluoroethanol Properties 

Hazard Identification

Classification of the substance or mixture

Flammable liquids, Category 3

Acute toxicity - Category 3, Oral

Serious eye damage, Category 1

Acute toxicity - Category 3, Inhalation

Reproductive toxicity, Category 1B

Specific target organ toxicity â repeated exposure, Category 2

GHS label elements, including precautionary statements

Precautionary statement(s)
Pictogram(s)
Signal word	Danger
Hazard statement(s)	H226 Flammable liquid and vapour H301+H331 Toxic if swallowed or if inhaled H318 Causes serious eye damage H360 May damage fertility or the unborn child H373 May cause damage to organs through prolonged or repeated exposure
Prevention	P210 Keep away from heat, hot surfaces, sparks, open flames and other ignition sources. No smoking. P233 Keep container tightly closed. P240 Ground and bond container and receiving equipment. P241 Use explosion-proof [electrical/ventilating/lighting/...] equipment. P242 Use non-sparking tools. P243 Take action to prevent static discharges. P280 Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/... P264 Wash ... thoroughly after handling. P270 Do not eat, drink or smoke when using this product. P261 Avoid breathing dust/fume/gas/mist/vapours/spray. P271 Use only outdoors or in a well-ventilated area. P203 Obtain, read and follow all safety instructions before use. P260 Do not breathe dust/fume/gas/mist/vapours/spray.
Response	P303+P361+P353 IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse affected areas with water [or shower]. P370+P378 In case of fire: Use ... to extinguish. P301+P316 IF SWALLOWED: Get emergency medical help immediately. P321 Specific treatment (see ... on this label). P330 Rinse mouth. P305+P354+P338 IF IN EYES: Immediately rinse with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P317 Get medical help. P304+P340 IF INHALED: Remove person to fresh air and keep comfortable for breathing. P316 Get emergency medical help immediately. P318 IF exposed or concerned, get medical advice. P319 Get medical help if you feel unwell.
Storage	P403+P235 Store in a well-ventilated place. Keep cool. P405 Store locked up. P403+P233 Store in a well-ventilated place. Keep container tightly closed.
Disposal	P501 Dispose of contents/container to an appropriate treatment and disposal facility in accordance with applicable laws and regulations, and product characteristics at time of disposal.

Other hazards which do not result in classification

no data available

Handling and Storage

Precautions for safe handling

Handling in a well ventilated place. Wear suitable protective clothing. Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Use non-sparking tools. Prevent fire caused by electrostatic discharge steam.

Conditions for safe storage, including any incompatibilities

Store the container tightly closed in a dry, cool and well-ventilated place. Store apart from foodstuff containers or incompatible materials.

See More 2,2,2-Trifluoroethanol Safety Data Sheet 

Seller Information

Business Type:
Trader

Main Products:
pharmaceutical intermediates,peptides,electronic chemicals

Location:
Room 102, 1st Floor, East Office Building, No. 45 Pengwan Road, Qianwan Bonded Port Area, Qingdao Zone, China (Shandong) Pilot Free Trade Zone

Payment Terms:
100% TT in advance

Average lead Time:
10

Total Annual Revenue:
$10 million-$25 million

Total Employees:
51-100

Year of Establishment:
2024

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We are mainly specilized in supply of pharmaceutical intermediates, electronic chemicals，food additives, and other fine chemical products.
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Website: orientchem.cc
Email: scarlett@orientchem.cc
WhatsApp: +86 17753254221

Inquiry History

4 Inquiries

Country	Product	Purchase Quantity	Date Posted
India	222 Trifluoroethanol	100.00 KG	Dec 8, 2023
United States	2,2,2-Trifluoroethanol 99% Colorless transparent liquid	1 MT	Sep 23, 2023
Canada	Trifluoroethanol	1 MT	Mar 12, 2024
India	Trifluro ethanol	1000 L	Jan 4, 2024

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