(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile High Purity Intermediate CAS 170862-36-9 NT

(2S,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-methyl-4-(1H-1,2,4-triazol-1-yl)butanenitrile (CAS 170862-36-9) is a key chiral intermediate in the synthesis of Efinaconazole, a novel triazole antifungal drug indicated for the topical treatment of onychomycosis (fungal nail infection). It is also identified as Isavuconazole Impurity 4 and serves as an important reference standard in pharmaceutical quality control .

This compound contains a triazole moiety and a chiral hydroxyl-nitrile structure, which are essential for the biological activity of the final API. It functions as a key building block in the synthesis of antifungal agents, inhibiting ergosterol biosynthesis in fungal cell membranes .

This high-purity intermediate is widely used in pharmaceutical R&D, analytical method development, and quality control applications, including ANDA filing and commercial production of Efinaconazole.

Key Features:

• High Purity: ≥ 95% (HPLC), meeting rigorous quality standards 

• Key Chiral Intermediate: Essential for the synthesis of Efinaconazole API

• Impurity Reference Standard: Identified as Isavuconazole Impurity 4 for QC applications 

• Analytical Grade: Suitable for use as a reference standard and impurity identification

• Regulatory Support: Can be provided with detailed characterization data compliant with regulatory guideline

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Applications:

• Pharmaceutical Industry: As a key intermediate in the synthesis of Efinaconazole API

• Analytical R&D: For method development, method validation, and quality control applications

• Regulatory Filing: Used as a reference standard in ANDA and DMF submissions

• Impurity Profiling: As a reference standard for Isavuconazole impurity identification 

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Packaging: ___ (1g, 5g, 10g, 25kg per package, as per customer's request)

Storage: Store in a cool, dry, well-ventilated area, away from direct sunlight and moisture. Recommended storage temperature: 2-8°C (Refrigerator) for long-term storage.