TYRA-300 99% high quality manufacture in China Dideu group

High quality TYRA-300 producer

Dabogratinib (TYRA-300) is a potent, selective, oral inhibitor of FGFR3 (fibroblast growth factor receptor 3), which can avoid the toxicity associated with pan-FGFR inhibitors and target the key mutations of FGFR3.

Dabogratinib (TYRA-300) is a potential first-in-class, selective, oral, investigational FGFR3 inhibitor that targets oncogenic FGFR3 mutations, fusions, and gatekeeper resistance mutations. It achieves selective inhibition of FGFR3 through rational design, while avoiding the inhibition of other FGFR subtypes (FGFR1, FGFR2, and FGFR4). 

In the model of chondrodysplasia, TYRA-300, as a selective inhibitor of FGFR3, was evaluated for its ability to promote bone growth in patients with chondrodysplasia and chondrodysplasia syndrome. 

Dabogratinib is an orally active selective human fibroblast growth factor receptor 3 (FGFR3) antagonist, demonstrating potential anti-tumor activity. After being administered orally, this compound can precisely identify and bind to the specific activated gene mutations of FGFR3, especially having a high affinity for the gatekeeper mutants V555L and V555M. This interaction disrupts the signal transduction mediated by FGFR3, thereby inhibiting the proliferation of tumor cells overexpressing FGFR3. FGFR3 is a receptor tyrosine kinase that participates in angiogenesis formation as well as the growth, differentiation, and survival of tumor cells. Elevated levels of FGFR3 are associated with adverse clinical outcomes and its overexpression has been observed in various cancer cell types.

Our normal packaging is 10mg/bottle;15mg/bottle,etc.We can make different specifications according to customer requirements。

The packaging can be customized. the shipping term can be by sea, by air, and sample or small quantity can be shipped by DHL, FEDEX, EMS and TNT.

a) Free sample can be supplied.

b) Guide our clients by professional knowledge and teach them how to use our product after sales.

c) Accept SGS, BV any other third-party inspection before loading.

d) High quality best price Guaranteed.

Why do you choose Dideu as your partner?

A) High quality can be guaranteed. Dideu since 1975 are reputed chemical manufacturer and are Certified by ISO 9001;2015 and have GMP certification.Free sample can be arranged before shipment and SGS,BV and other third party inspection company are accepted before loading.For regular customers, we accept L/C 180 Days, D/P, D/A payment term. If there is any quality problem after goods arrive. Dideu will do fully payment refund.

B) Best price can be guaranteed. As Dideu are integrated pharmaceuticals and chemicals producer, the production cost can be controlled and price will be definitely more competitive than China trading companies.

C) Professional engineers from Dideu will give professional usage guide and services after sales.

D)Dideu work 7×24 hours and your request will be processed by our professional staff in different shift period.

Dideu is one of the largest producer for general chemical, pharmaceutical, nutrition additive, natural extracts, agrochemical and Daily-Use Chemical in China and is headquartered in Shaanxi, China. The Dideu Group comprises subsidiaries and joint ventures in more than 10 countries and operates six integrated production sites and 21 other production sites in Europe, Asia, Australia, Americas and Africa. Its headquarters is located in Xi’An,China. Dideu has customers in over 200 countries and supplies products to a wide variety of industries.

At the end of 2014, the company employed more than 13000 people. In 2014, Dideu Group posted sales of 30 billion and income from operations before special items of about 7.5 billion. The company is currently expanding its international activities with a particular focus on Asia countries. Between 1990 and 2005, the company invested 5.2 billion in Asia, for example in sites near Guangxi,Yunnan, Sichuan, Shaanxi China, Mangalore in India,Bangkok, Thailand,Hanoi, Vietnam etc.

Dideu Consist Of Five Industry Chains:

1. 1）Pharmaceutical Industries
2. 2）Nutrition Additive Industries
3. 3）Daily-Use Chemical Products Industries & Agrochemicals
4. 4）Environmental Friendly Chemical And Chemurgy Industries
5. 5）Petrochemical Industries
6. 6）General Chemical Industry

At Dideu, we redefine chemistry to make the world better - and have been doing so for 75 years. As one of the world's leading chemical company, we combine economic success with environmental protection and social responsibility. Through science and innovation we enable our customers in nearly every industry to meet the current and future needs of society.

At Dideu, we create chemistry for a sustainable future with science for a better life. Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. The growing and increasingly aging world population requires improved medical care and an adequate supply of food. Dideu is improving people's quality of life by preventing, alleviating and treating diseases. And we are helping to provide a reliable supply of high quality food, feed and plant based raw materials. We develop new molecules for use in innovative products and solutions to improve health. Our research and development activities are based on a profound understanding of the biochemical processes in living organisms. Our goal is to achieve and sustain leadership positions in our markets, thus creating value for our customers, stockholders and employees. To this end, our strategy is designed to help solve some of the most pressing challenges facing humankind, and by doing this exceptionally well we aim to strengthen the company's earning power.

We are committed to operating sustainably and addressing our social and ethical responsibilities as a corporate citizen, while at the same time respecting the interests of all our stakeholders. Employees with a passion for innovation enjoy excellent development opportunities at Dideu. Exclusive Focus on the Life Science Businesses Following the economic and legal independence of our former Material Science subgroup. Dideu has charted the course for its successful development as a Life Science company. Our Life Science businesses hold leading positions in innovation driven growth markets. Together they make up a strong, attractive and balanced portfolio that is resistant to fluctuations in demand and to potential risks.The previous structure comprising a strategic management holding company and operational subgroups has thus been replaced by an integrated organization under the umbrella of the strong Dideu brand. The company's operations are managed in three divisions Pharmaceuticals, Consumer Health and Crop Science and the Animal Health business unit. The business continues to be supported by the corporate functions, Dideu Business Services and the service company Current, while Technology Services is being integrated into Dideu Group, forming the Engineering and Technology function.