—— Product Specifications ——
—— Product Detail ——
Product Overview
5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (CAS 478828-53-4), also known as 5-bromo-1-(oxan-2-yl)-1H-indazole, is an indazole derivative with the molecular formula C₁₂H₁₃BrN₂O and a molecular weight of 281.15 g/mol. The compound features a bromine at the 5-position of the indazole ring and a tetrahydropyranyl (THP) protecting group at the 1-position. This THP-protected indazole is widely used as a versatile intermediate in organic synthesis.
Synthetic Process
The synthesis of this compound typically involves the THP protection of 5-bromoindazole. This is achieved by reacting 5-bromoindazole with 3,4-dihydro-2H-pyran (DHP) in the presence of an acid catalyst such as p-toluenesulfonic acid or pyridinium p-toluenesulfonate (PPTS) in an appropriate solvent like dichloromethane or THF.
Mechanism of Action
As a THP-protected indazole, this compound serves as a stable intermediate that allows selective deprotection and functionalization. The THP group can be readily removed under mild acidic conditions, revealing the indazole NH for further reactions.
Quality Specifications
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Purity: ≥95.0% determined by HPLC
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Identity confirmed by NMR and mass spectrometry
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Each batch accompanied by comprehensive Certificate of Analysis (COA)
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Store in a cool, dry place
Packaging & Shipping
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Research quantities: 1g, 5g, 10g amber glass vials
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Bulk quantities: 25g, 100g amber glass bottles
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Custom packaging available upon request
— C ompany Profile ——
Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.
Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.
We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.
To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.
Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.
—— Q&A ——
Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.
Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.
Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.
Q4: What is your MOQ? Is there a discount?
A: For high value products, our MOQ starts from 1g and generally starts from 10g. For other low price products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.
Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.
