—— Product Specifications ——

—— Product Detail ——

• • • • • • • • • • • • • • • • • • • • Product Overview

                                        5-Acetyl-2-amino-4-methylthiazole is a heterocyclic organic compound with the molecular formula C₆H₈N₂OS and a molecular weight of 156.20 g/mol. This white to pale yellow crystalline powder features a thiazole ring substituted with amino, acetyl, and methyl groups, making it a versatile building block in organic synthesis and pharmaceutical research.

                                        The compound's unique substitution pattern provides multiple sites for chemical modification, including the amino group for derivatization, the acetyl group for condensation reactions, and the methyl group for oxidation or halogenation. It serves as a key intermediate in the synthesis of various bioactive molecules, including enzyme inhibitors, antimicrobial agents, and kinase inhibitors.

                                        Synthetic Process

                                        5-Acetyl-2-amino-4-methylthiazole is synthesized through the following routes:

                                        • Hantzsch thiazole synthesis: A suitable α-halo ketone (such as chloroacetone or bromoacetone derivative) is reacted with thiourea or a substituted thiourea derivative to form the aminothiazole ring, followed by acetylation or introduction of the acetyl group.

                                        • Acetylation of 2-amino-4-methylthiazole: 2-Amino-4-methylthiazole is acetylated using acetic anhydride or acetyl chloride in the presence of a Friedel-Crafts catalyst (such as aluminum chloride) to introduce the acetyl group at the 5-position.

                                        • Purification: The crude product is purified by recrystallization from ethanol or suitable solvent mixtures.

                                        Mechanism of Action / Application Principles

                                        • Pharmaceutical Synthesis: Used as a building block for the synthesis of thiazole-containing bioactive molecules, including kinase inhibitors, antimicrobial agents, and anti-inflammatory compounds.

                                        • Agrochemical Research: Serves as an intermediate in the synthesis of herbicides and fungicides.

                                        • Heterocyclic Chemistry: The thiazole ring system is present in numerous natural products and pharmaceuticals, making this compound a valuable precursor for further functionalization.

                                        • Ligand Synthesis: The aminothiazole moiety can serve as a metal-binding motif in coordination chemistry.

— C ompany Profile ——

Jinan Topfull Chemical Co., Ltd. is an international company rooted in China, specializing in the export of chemical products.

Our company is committed to making every effort to provide ideal chemical products to potential customers worldwide, including but not limited to: organic/inorganic reagents, biological reagents, plant extracts, pharmaceutical intermediates, active pharmaceutical ingredients (APIs), reference standards, reference substances, peptides, and more. Meanwhile, we have established long-term and stable cooperative relationships with university laboratories and off-campus research institutions, enabling us to offer tailored product services based on customers' actual needs.

We currently support customized services for most product categories, with supply quantities ranging from milligram (mg), gram (g) to kilogram (kg) levels, as well as wholesale. Product purity covers the full spectrum from 90% to 99.9%, providing customers with one-stop convenient services.

To date, our products have been exported to developed countries such as the United States, Australia, Canada, Mexico, as well as EU member states including France, Germany, and many other countries and regions such as Nigeria, Ghana, Southeast Asia, and other parts of Asia. Our product quality and services have consistently received high praise.

Looking ahead, our company will continue to serve as a bridge connecting China and the world, delivering high-quality products and services to global customers.

—— Q&A ——

Q1: How to confirm the product quality before placing orders?
A: By sending you available samples. Or if you have special requirements for the goods, we can prepare samples according to your requirements for confirmation.

Q2: Can you supply free samples?
A: Yes, we can provide a free sample, but the shipping cost will be paid by the customers. You can either pay the shipping cost or arrange a courier to collect the samples.

Q3: How do you treat quality complaints?
A: All our products are strictly tested by our QC and confirmed by QA; unqualified material will not be released to customers. If any quality problem is confirmed to be caused by us, we will replace the goods or refund your payment immediately.

Q4: What is your MOQ? Is there a discount?
A: For highvalue products, our MOQ starts from 1g and generally starts from 10g. For other lowprice products, our MOQ starts from 100g and 1kg.
Q: Is there a discount?
A: Yes, for larger quantities, we always support with better prices.

Q5: How to start orders or make payments?
A: You can send us your Purchase Order (if your company has one), or just send a simple confirmation by email or via Trade Manager. We will then send you a Proforma Invoice with our bank details for your confirmation, and you can make payment accordingly. If you have other preferred payment methods, we are open to discussion and negotiation.