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I. Direct Broad-Spectrum Antimicrobial (Core Function)
1. Anti-Bacterial (Effective against both Gram-negative and Gram-positive bacteria, including drug-resistant strains)
- Gram-negative: Escherichia coli, Pseudomonas aeruginosa, Acinetobacter baumannii; neutralize LPS (endotoxin), inhibit sepsis inflammatory storm
- Gram-positive: Staphylococcus aureus (including MRSA resistant strains), Streptococcus, Streptococcus pneumoniae
- Additional capabilities: Dissolve bacterial biofilms, promote neutrophil release of NET to capture and kill bacteria
2. Anti-Fungal
Candida albicans, Aspergillus; damage fungal cell membranes, disrupt calcium homeostasis, induce mitochondrial oxidative stress, inhibit fungal hypha formation.
3. Anti-Viral
Enveloped viruses: Influenza, HIV, COVID-19, Herpes virus; directly destroy viral envelope, block virus attachment to host cells.
4. Anti-Parasitic
Inhibit the proliferation of Toxoplasma gondii and Leishmania.
II. Neutralizing endotoxins and inhibiting excessive inflammation (anti-inflammatory protection)
The LPS released by bacterial death can trigger severe inflammation and shock.
1. LL-37 binds to LPS, preventing LPS from activating the TLR4 pathway and reducing the release of pro-inflammatory factors such as TNF-α and IL-6;
2. Alleviating sepsis, pulmonary infections, and uncontrolled inflammation in skin wounds;
3. Bidirectional regulation of inflammation: low concentration promotes immune activation, high concentration inhibits excessive inflammation, avoiding tissue damage.
III. Immune Regulation (Chemotaxis + Activation of Immune Cells)
1. Recruiting immune cells through chemotaxis: As chemotactic factors, they attract neutrophils, macrophages, dendritic cells, and T cells to the infected area;
2. Activating macrophages to phagocytose and eliminate pathogens, enhancing antigen presentation;
3. Stimulating epithelial and immune cells to secrete cytokines, coordinating innate immunity and adaptive immunity;
4. Stabilizing the extracellular trapping network (NET) of neutrophils, preventing bacterial nucleases from degrading NET and continuously capturing pathogens.
IV. Tissue Repair and Wound Healing (Skin/Mucous Membrane Focus)
1. Activate EGFR (epidermal growth factor receptor), promoting the migration and proliferation of keratinocytes and epithelial cells, accelerating the repair of skin, intestinal tract, and respiratory tract mucous membranes;
2. Promote angiogenesis (stimulate endothelial cell proliferation), improving blood supply to the wound site;
3. Reduce scar formation at the wound site, maintaining the integrity of the mucous membrane barrier;
4. Protect the intestinal epithelial barrier in the intestine, reduce bacterial translocation, and maintain intestinal homeostasis.
V. Anti-tumor
Protective effect
- Directly kills some tumor cells (lung cancer, liver cancer, colorectal cancer cells), damages the tumor cell membrane;
- Inhibits tumor proliferation, invasion and metastasis, angiogenesis;
- Activates the body's anti-tumor immunity, enhances the killing ability of immune cells against tumors.
Carcinogenic risk (high concentration / chronic inflammatory environment)
Chronic inflammation with high LL-37 concentration can promote the proliferation of some tumors, and has a dual effect in ulcerative colitis-related colorectal cancer and cutaneous squamous cell carcinoma.
VI. Participating in skin barrier and mucosal homeostasis
1. Skin: Secreted by sebaceous glands and keratinocytes, resisting skin microbiota, Propionibacterium acnes; Insufficient LL-37 is prone to atopic dermatitis and psoriasis;
2. Respiratory tract: Secreted by airway epithelium, preventing pneumonia and sinusitis;
3. Intestine: Secreted by intestinal crypts, balancing intestinal microbiota, reducing the risk of inflammatory bowel disease.
| Items | Specifications |
| Product Name | 375 |
| Purity | 99.9% |
| Storage Condition | Seal and store in cool dry place |
Hong Kong Biopetide Research Limited is a high-tech enterprise specializing in the research, development, production, and sales of peptide products. The company boasts advanced laboratories and a rigorous quality control system, with its products having obtained multiple international certifications, ensuring safety and efficacy.
Its customers are spread across Europe, the United States, Southeast Asia, the Middle East, and other regions.
Biotechnology Co., Ltd. is a high-tech enterprise specializing in the research, development, production, and sales of peptide products. With advanced laboratories and a rigorous quality control system, our products have obtained international certification, ensuring safety and efficacy.
As a global trading company, we provide customized solutions to customers across Europe, the United States, Southeast Asia, the Middle East, and many other regions. Upholding the philosophy of "technology leading health," we are committed to innovation, striving to deliver high-quality health products to consumers worldwide. Our business principles focus on establishing a strong domestic market presence, increasing R&D investment, manufacturing premium products, and leveraging technology to promote environmental protection and sustainable development. At the same time, we actively expand into international markets, serve society with sincerity, and aim to become a modern, eco-friendly, and technologically advanced enterprise that meets global standards. Contact Us
Our products have been exported to 130 countries and regions. We are committed to building stable, strategic, and long-term partnerships with suppliers and customers both domestically and internationally, working together to create a brighter future.
1. We are the source factory of raw materials, offering high-quality and high-purity raw materials at wholesale prices.
2. We can provide global delivery services and have an exclusive delivery team to ensure safety and speed.
3. You can contact us to inquire about any products. Our product range is extensive and we support customization to meet your needs as much as possible.
4. We support various payment methods and all details can be negotiated.
5. If you have any questions, please feel free to contact me. I will do my best to answer your questions for you.
6. Firstly, we guarantee the quality of the products; secondly, we guarantee the efficiency of transportation and the clearance rate; thirdly, we will provide you with the best service in all aspects.
You get what you pay for. If you have any questions, I will answer them all.
We mainly adopt dedicated logistics and FedEx transportation methods, which can ensure timely shipment, quick delivery, stable logistics tracking, and safe and punctual delivery.
Indonesia
